Changes in version 1.5.2 o Added function addReinitiationFlag. Changes in version 1.1.25 o Added a warning message when having duplicated gRNAs. Changes in version 1.1.21 o Fixed intergenic annotation of alignments when non-standard chromosomes are found. Changes in version 1.1.20 o flattenGuideSet is now GuideSet2DataFrames. Changes in version 1.1.19 o Changed argument standard_chr_only to FALSE by default in the functions getSpacerAlignments and friends. Changes in version 1.1.18 o Updated the object guideSetExampleWithAlignments to contain the latest annotations. Changes in version 1.1.17 o Updated the object guideSetExampleFullAnnotation to contain the latest annotations. Changes in version 1.1.12 o Refactored addGeneAnnotation. Changes in version 1.1.10 o Added the function getPreMrnaSequence. Changes in version 1.1.8 o Added features for non-targeting controls (addNtcs). Changes in version 1.0.0 o New package crisprDesign, for the design of CRISPR gRNA.