To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("motifbreakR")

In most cases, you don't need to download the package archive at all.

motifbreakR

DOI: 10.18129/B9.bioc.motifbreakR    

A Package For Predicting The Disruptiveness Of Single Nucleotide Polymorphisms On Transcription Factor Binding Sites

Bioconductor version: Release (3.6)

We introduce motifbreakR, which allows the biologist to judge in the first place whether the sequence surrounding the polymorphism is a good match, and in the second place how much information is gained or lost in one allele of the polymorphism relative to another. MotifbreakR is both flexible and extensible over previous offerings; giving a choice of algorithms for interrogation of genomes with motifs from public sources that users can choose from; these are 1) a weighted-sum probability matrix, 2) log-probabilities, and 3) weighted by relative entropy. MotifbreakR can predict effects for novel or previously described variants in public databases, making it suitable for tasks beyond the scope of its original design. Lastly, it can be used to interrogate any genome curated within Bioconductor (currently there are 22).

Author: Simon Gert Coetzee [aut, cre] Dennis J. Hazelett [aut]

Maintainer: Simon Gert Coetzee <Simon.Coetzee at cshs.org>

Citation (from within R, enter citation("motifbreakR")):

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("motifbreakR")

Documentation

HTML R Script motifbreakR: an Introduction
PDF   Reference Manual

Details

biocViews ChIPSeq, MotifAnnotation, Software, Visualization
Version 1.8.0
In Bioconductor since BioC 3.2 (R-3.2) (2 years)
License GPL-2
Depends R (>= 3.2), grid, MotifDb
Imports methods, compiler, grDevices, grImport, stringr, BiocGenerics, S4Vectors(>= 0.9.25), IRanges, GenomeInfoDb, GenomicRanges, Biostrings, BSgenome, rtracklayer, VariantAnnotation, BiocParallel, motifStack, Gviz, matrixStats, TFMPvalue
LinkingTo
Suggests BSgenome.Hsapiens.UCSC.hg19, SNPlocs.Hsapiens.dbSNP.20120608, SNPlocs.Hsapiens.dbSNP142.GRCh37, knitr, rmarkdown, BSgenome.Drerio.UCSC.danRer7, BiocStyle
SystemRequirements
Enhances
URL
BugReports https://github.com/Simon-Coetzee/motifbreakR/issues
Depends On Me
Imports Me
Suggests Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package motifbreakR_1.8.0.tar.gz
Windows Binary motifbreakR_1.8.0.zip
Mac OS X 10.11 (El Capitan) motifbreakR_1.8.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/motifbreakR
Package Short Url http://bioconductor.org/packages/motifbreakR/
Package Downloads Report Download Stats

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