Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.
If you have questions, please direct it to: Macarron Forum
Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:
if(!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("Macarron")
Macarron can be run from the command line or as an R function. Both methods require the same
arguments, have the same options, and use the same default settings. The package includes the
wrapper Macarron()
as well as functions which perform different steps in the Macarron
framework.
Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.
If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID
(see Advanced Topics).
By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv
. Another file, prioritized_metabolites_characterizable.csv
is a subset of prioritized_metabolites_all.csv
and only contains metabolic features which covary with at least one annotated metabolite.
The columns in these output files are:
Maaslin2
.Example (demo) input files can be found under inst/extdata
folder of the Macarron
source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv
, demo_annotations.csv
, demo_metadata.csv
, and demo_taxonomy.csv
.
library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
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## Welcome to Bioconductor
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prism_abundances <- system.file(
'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
input_annotations = prism_annotations,
input_metadata = prism_metadata,
input_taxonomy = mets_taxonomy)
## 2025-04-23 17:17:27.753882 INFO::Creating output folder.
## 2025-04-23 17:17:27.773212 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2025-04-23 17:17:27.858919 INFO::Summarized Experiment created.
## 2025-04-23 17:17:27.86119 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
##
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2025-04-23 17:17:32.793775 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2025-04-23 17:17:32.795802 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## 2025-04-23 17:17:35.683619 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2025-04-23 17:17:38.205895 INFO::Writing function arguments to log file
## 2025-04-23 17:17:38.214623 INFO::Verifying options selected are valid
## 2025-04-23 17:17:38.275802 INFO::Determining format of input files
## 2025-04-23 17:17:38.277094 INFO::Input format is data samples as columns and metadata samples as rows
## 2025-04-23 17:17:38.298485 INFO::Formula for fixed effects: expr ~ diagnosis + age + antibiotics
## 2025-04-23 17:17:38.301188 INFO::Filter data based on min abundance and min prevalence
## 2025-04-23 17:17:38.30221 INFO::Total samples in data: 102
## 2025-04-23 17:17:38.303552 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2025-04-23 17:17:38.317993 INFO::Total filtered features: 0
## 2025-04-23 17:17:38.319308 INFO::Filtered feature names from abundance and prevalence filtering:
## 2025-04-23 17:17:38.342559 INFO::Total filtered features with variance filtering: 0
## 2025-04-23 17:17:38.344157 INFO::Filtered feature names from variance filtering:
## 2025-04-23 17:17:38.34522 INFO::Running selected normalization method: NONE
## 2025-04-23 17:17:38.346448 INFO::Applying z-score to standardize continuous metadata
## 2025-04-23 17:17:38.372858 INFO::Running selected transform method: NONE
## 2025-04-23 17:17:38.374162 INFO::Running selected analysis method: LM
## 2025-04-23 17:17:38.381493 INFO::Fitting model to feature number 1, F1
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## 2025-04-23 17:17:39.310613 INFO::Fitting model to feature number 183, F189
## 2025-04-23 17:17:39.315816 INFO::Fitting model to feature number 184, F190
## 2025-04-23 17:17:39.32025 INFO::Fitting model to feature number 185, F191
## 2025-04-23 17:17:39.325708 INFO::Fitting model to feature number 186, F192
## 2025-04-23 17:17:39.330525 INFO::Fitting model to feature number 187, F193
## 2025-04-23 17:17:39.335334 INFO::Fitting model to feature number 188, F194
## 2025-04-23 17:17:39.341141 INFO::Fitting model to feature number 189, F195
## 2025-04-23 17:17:39.346095 INFO::Fitting model to feature number 190, F196
## 2025-04-23 17:17:39.350899 INFO::Fitting model to feature number 191, F197
## 2025-04-23 17:17:39.355604 INFO::Fitting model to feature number 192, F198
## 2025-04-23 17:17:39.359837 INFO::Fitting model to feature number 193, F199
## 2025-04-23 17:17:39.365466 INFO::Fitting model to feature number 194, F200
## 2025-04-23 17:17:39.369948 INFO::Fitting model to feature number 195, F201
## 2025-04-23 17:17:39.374312 INFO::Fitting model to feature number 196, F202
## 2025-04-23 17:17:39.378568 INFO::Fitting model to feature number 197, F203
## 2025-04-23 17:17:39.382712 INFO::Fitting model to feature number 198, F204
## 2025-04-23 17:17:39.38695 INFO::Fitting model to feature number 199, F206
## 2025-04-23 17:17:39.392777 INFO::Fitting model to feature number 200, F207
## 2025-04-23 17:17:39.399848 INFO::Fitting model to feature number 201, F208
## 2025-04-23 17:17:39.40493 INFO::Fitting model to feature number 202, F209
## 2025-04-23 17:17:39.409776 INFO::Fitting model to feature number 203, F210
## 2025-04-23 17:17:39.415221 INFO::Fitting model to feature number 204, F211
## 2025-04-23 17:17:39.420868 INFO::Fitting model to feature number 205, F212
## 2025-04-23 17:17:39.427235 INFO::Fitting model to feature number 206, F213
## 2025-04-23 17:17:39.433342 INFO::Fitting model to feature number 207, F214
## 2025-04-23 17:17:39.439285 INFO::Fitting model to feature number 208, F215
## 2025-04-23 17:17:39.445101 INFO::Fitting model to feature number 209, F216
## 2025-04-23 17:17:39.44925 INFO::Fitting model to feature number 210, F217
## 2025-04-23 17:17:39.454466 INFO::Fitting model to feature number 211, F218
## 2025-04-23 17:17:39.459485 INFO::Fitting model to feature number 212, F219
## 2025-04-23 17:17:39.464776 INFO::Fitting model to feature number 213, F220
## 2025-04-23 17:17:39.470191 INFO::Fitting model to feature number 214, F221
## 2025-04-23 17:17:39.474545 INFO::Fitting model to feature number 215, F222
## 2025-04-23 17:17:39.478753 INFO::Fitting model to feature number 216, F223
## 2025-04-23 17:17:39.484577 INFO::Fitting model to feature number 217, F224
## 2025-04-23 17:17:39.489126 INFO::Fitting model to feature number 218, F225
## 2025-04-23 17:17:39.493679 INFO::Fitting model to feature number 219, F226
## 2025-04-23 17:17:39.499231 INFO::Fitting model to feature number 220, F227
## 2025-04-23 17:17:39.550006 INFO::Fitting model to feature number 221, F228
## 2025-04-23 17:17:39.555395 INFO::Fitting model to feature number 222, F229
## 2025-04-23 17:17:39.560712 INFO::Fitting model to feature number 223, F230
## 2025-04-23 17:17:39.566234 INFO::Fitting model to feature number 224, F231
## 2025-04-23 17:17:39.571195 INFO::Fitting model to feature number 225, F232
## 2025-04-23 17:17:39.575731 INFO::Fitting model to feature number 226, F233
## 2025-04-23 17:17:39.579951 INFO::Fitting model to feature number 227, F234
## 2025-04-23 17:17:39.584562 INFO::Fitting model to feature number 228, F235
## 2025-04-23 17:17:39.590322 INFO::Fitting model to feature number 229, F236
## 2025-04-23 17:17:39.596287 INFO::Fitting model to feature number 230, F237
## 2025-04-23 17:17:39.602 INFO::Fitting model to feature number 231, F238
## 2025-04-23 17:17:39.60729 INFO::Fitting model to feature number 232, F239
## 2025-04-23 17:17:39.61111 INFO::Fitting model to feature number 233, F240
## 2025-04-23 17:17:39.616079 INFO::Fitting model to feature number 234, F241
## 2025-04-23 17:17:39.620574 INFO::Fitting model to feature number 235, F242
## 2025-04-23 17:17:39.62536 INFO::Fitting model to feature number 236, F243
## 2025-04-23 17:17:39.629008 INFO::Fitting model to feature number 237, F244
## 2025-04-23 17:17:39.63326 INFO::Fitting model to feature number 238, F245
## 2025-04-23 17:17:39.637208 INFO::Fitting model to feature number 239, F246
## 2025-04-23 17:17:39.642179 INFO::Fitting model to feature number 240, F247
## 2025-04-23 17:17:39.647437 INFO::Fitting model to feature number 241, F248
## 2025-04-23 17:17:39.65254 INFO::Fitting model to feature number 242, F249
## 2025-04-23 17:17:39.657426 INFO::Fitting model to feature number 243, F250
## 2025-04-23 17:17:39.662063 INFO::Fitting model to feature number 244, F252
## 2025-04-23 17:17:39.665972 INFO::Fitting model to feature number 245, F253
## 2025-04-23 17:17:39.670368 INFO::Fitting model to feature number 246, F254
## 2025-04-23 17:17:39.674269 INFO::Fitting model to feature number 247, F255
## 2025-04-23 17:17:39.678408 INFO::Fitting model to feature number 248, F256
## 2025-04-23 17:17:39.682963 INFO::Fitting model to feature number 249, F257
## 2025-04-23 17:17:39.688244 INFO::Fitting model to feature number 250, F259
## 2025-04-23 17:17:39.693511 INFO::Fitting model to feature number 251, F260
## 2025-04-23 17:17:39.697805 INFO::Fitting model to feature number 252, F261
## 2025-04-23 17:17:39.701989 INFO::Fitting model to feature number 253, F262
## 2025-04-23 17:17:39.706816 INFO::Fitting model to feature number 254, F263
## 2025-04-23 17:17:39.712103 INFO::Fitting model to feature number 255, F264
## 2025-04-23 17:17:39.717459 INFO::Fitting model to feature number 256, F265
## 2025-04-23 17:17:39.723569 INFO::Fitting model to feature number 257, F266
## 2025-04-23 17:17:39.730114 INFO::Fitting model to feature number 258, F267
## 2025-04-23 17:17:39.734135 INFO::Fitting model to feature number 259, F269
## 2025-04-23 17:17:39.738973 INFO::Fitting model to feature number 260, F270
## 2025-04-23 17:17:39.742591 INFO::Fitting model to feature number 261, F271
## 2025-04-23 17:17:39.746164 INFO::Fitting model to feature number 262, F272
## 2025-04-23 17:17:39.751476 INFO::Fitting model to feature number 263, F273
## 2025-04-23 17:17:39.756415 INFO::Fitting model to feature number 264, F274
## 2025-04-23 17:17:39.760542 INFO::Fitting model to feature number 265, F276
## 2025-04-23 17:17:39.764651 INFO::Fitting model to feature number 266, F277
## 2025-04-23 17:17:39.768565 INFO::Fitting model to feature number 267, F278
## 2025-04-23 17:17:39.772971 INFO::Fitting model to feature number 268, F279
## 2025-04-23 17:17:39.777471 INFO::Fitting model to feature number 269, F280
## 2025-04-23 17:17:39.782065 INFO::Fitting model to feature number 270, F281
## 2025-04-23 17:17:39.787265 INFO::Fitting model to feature number 271, F282
## 2025-04-23 17:17:39.793033 INFO::Fitting model to feature number 272, F283
## 2025-04-23 17:17:39.798201 INFO::Fitting model to feature number 273, F284
## 2025-04-23 17:17:39.802937 INFO::Fitting model to feature number 274, F285
## 2025-04-23 17:17:39.807492 INFO::Fitting model to feature number 275, F286
## 2025-04-23 17:17:39.81246 INFO::Fitting model to feature number 276, F287
## 2025-04-23 17:17:39.817496 INFO::Fitting model to feature number 277, F288
## 2025-04-23 17:17:39.821593 INFO::Fitting model to feature number 278, F289
## 2025-04-23 17:17:39.826089 INFO::Fitting model to feature number 279, F290
## 2025-04-23 17:17:39.831475 INFO::Fitting model to feature number 280, F292
## 2025-04-23 17:17:39.836212 INFO::Fitting model to feature number 281, F293
## 2025-04-23 17:17:39.841912 INFO::Fitting model to feature number 282, F294
## 2025-04-23 17:17:39.847411 INFO::Fitting model to feature number 283, F295
## 2025-04-23 17:17:39.851711 INFO::Fitting model to feature number 284, F296
## 2025-04-23 17:17:39.856961 INFO::Fitting model to feature number 285, F297
## 2025-04-23 17:17:39.861826 INFO::Fitting model to feature number 286, F298
## 2025-04-23 17:17:39.865985 INFO::Fitting model to feature number 287, F299
## 2025-04-23 17:17:39.870142 INFO::Fitting model to feature number 288, F300
## 2025-04-23 17:17:39.874537 INFO::Fitting model to feature number 289, F301
## 2025-04-23 17:17:39.878558 INFO::Fitting model to feature number 290, F302
## 2025-04-23 17:17:39.883754 INFO::Fitting model to feature number 291, F303
## 2025-04-23 17:17:39.889385 INFO::Fitting model to feature number 292, F304
## 2025-04-23 17:17:39.895048 INFO::Fitting model to feature number 293, F305
## 2025-04-23 17:17:39.900527 INFO::Fitting model to feature number 294, F306
## 2025-04-23 17:17:39.904682 INFO::Fitting model to feature number 295, F307
## 2025-04-23 17:17:39.908471 INFO::Fitting model to feature number 296, F308
## 2025-04-23 17:17:39.913223 INFO::Fitting model to feature number 297, F309
## 2025-04-23 17:17:39.918814 INFO::Fitting model to feature number 298, F310
## 2025-04-23 17:17:39.923789 INFO::Fitting model to feature number 299, F311
## 2025-04-23 17:17:39.929559 INFO::Fitting model to feature number 300, F312
## 2025-04-23 17:17:39.935483 INFO::Fitting model to feature number 301, F313
## 2025-04-23 17:17:39.941696 INFO::Fitting model to feature number 302, F315
## 2025-04-23 17:17:39.947222 INFO::Fitting model to feature number 303, F316
## 2025-04-23 17:17:39.952584 INFO::Fitting model to feature number 304, F317
## 2025-04-23 17:17:39.95814 INFO::Fitting model to feature number 305, F318
## 2025-04-23 17:17:39.963023 INFO::Fitting model to feature number 306, F319
## 2025-04-23 17:17:39.967661 INFO::Fitting model to feature number 307, F320
## 2025-04-23 17:17:39.972058 INFO::Fitting model to feature number 308, F321
## 2025-04-23 17:17:39.976508 INFO::Fitting model to feature number 309, F322
## 2025-04-23 17:17:39.981528 INFO::Fitting model to feature number 310, F323
## 2025-04-23 17:17:39.986159 INFO::Fitting model to feature number 311, F324
## 2025-04-23 17:17:39.990607 INFO::Fitting model to feature number 312, F325
## 2025-04-23 17:17:39.995843 INFO::Fitting model to feature number 313, F326
## 2025-04-23 17:17:40.001167 INFO::Fitting model to feature number 314, F327
## 2025-04-23 17:17:40.006177 INFO::Fitting model to feature number 315, F328
## 2025-04-23 17:17:40.010598 INFO::Fitting model to feature number 316, F329
## 2025-04-23 17:17:40.015209 INFO::Fitting model to feature number 317, F330
## 2025-04-23 17:17:40.020545 INFO::Fitting model to feature number 318, F331
## 2025-04-23 17:17:40.025341 INFO::Fitting model to feature number 319, F332
## 2025-04-23 17:17:40.030678 INFO::Fitting model to feature number 320, F333
## 2025-04-23 17:17:40.035716 INFO::Fitting model to feature number 321, F334
## 2025-04-23 17:17:40.040014 INFO::Fitting model to feature number 322, F335
## 2025-04-23 17:17:40.044539 INFO::Fitting model to feature number 323, F336
## 2025-04-23 17:17:40.049009 INFO::Fitting model to feature number 324, F337
## 2025-04-23 17:17:40.053108 INFO::Fitting model to feature number 325, F338
## 2025-04-23 17:17:40.058109 INFO::Fitting model to feature number 326, F339
## 2025-04-23 17:17:40.062397 INFO::Fitting model to feature number 327, F340
## 2025-04-23 17:17:40.06798 INFO::Fitting model to feature number 328, F342
## 2025-04-23 17:17:40.072985 INFO::Fitting model to feature number 329, F343
## 2025-04-23 17:17:40.077718 INFO::Fitting model to feature number 330, F344
## 2025-04-23 17:17:40.083203 INFO::Fitting model to feature number 331, F345
## 2025-04-23 17:17:40.087588 INFO::Fitting model to feature number 332, F346
## 2025-04-23 17:17:40.092018 INFO::Fitting model to feature number 333, F347
## 2025-04-23 17:17:40.096682 INFO::Fitting model to feature number 334, F348
## 2025-04-23 17:17:40.10267 INFO::Fitting model to feature number 335, F350
## 2025-04-23 17:17:40.108121 INFO::Fitting model to feature number 336, F351
## 2025-04-23 17:17:40.112628 INFO::Fitting model to feature number 337, F352
## 2025-04-23 17:17:40.117185 INFO::Fitting model to feature number 338, F353
## 2025-04-23 17:17:40.122112 INFO::Fitting model to feature number 339, F355
## 2025-04-23 17:17:40.126291 INFO::Fitting model to feature number 340, F356
## 2025-04-23 17:17:40.130512 INFO::Fitting model to feature number 341, F357
## 2025-04-23 17:17:40.134403 INFO::Fitting model to feature number 342, F358
## 2025-04-23 17:17:40.138675 INFO::Fitting model to feature number 343, F359
## 2025-04-23 17:17:40.142833 INFO::Fitting model to feature number 344, F360
## 2025-04-23 17:17:40.146913 INFO::Fitting model to feature number 345, F361
## 2025-04-23 17:17:40.152284 INFO::Fitting model to feature number 346, F362
## 2025-04-23 17:17:40.156831 INFO::Fitting model to feature number 347, F363
## 2025-04-23 17:17:40.162003 INFO::Fitting model to feature number 348, F364
## 2025-04-23 17:17:40.167193 INFO::Fitting model to feature number 349, F365
## 2025-04-23 17:17:40.17238 INFO::Fitting model to feature number 350, F366
## 2025-04-23 17:17:40.178096 INFO::Fitting model to feature number 351, F367
## 2025-04-23 17:17:40.183979 INFO::Fitting model to feature number 352, F368
## 2025-04-23 17:17:40.189084 INFO::Fitting model to feature number 353, F369
## 2025-04-23 17:17:40.193539 INFO::Fitting model to feature number 354, F370
## 2025-04-23 17:17:40.197725 INFO::Fitting model to feature number 355, F371
## 2025-04-23 17:17:40.203522 INFO::Fitting model to feature number 356, F372
## 2025-04-23 17:17:40.209994 INFO::Fitting model to feature number 357, F373
## 2025-04-23 17:17:40.215185 INFO::Fitting model to feature number 358, F374
## 2025-04-23 17:17:40.219359 INFO::Fitting model to feature number 359, F375
## 2025-04-23 17:17:40.224035 INFO::Fitting model to feature number 360, F376
## 2025-04-23 17:17:40.230153 INFO::Fitting model to feature number 361, F377
## 2025-04-23 17:17:40.236321 INFO::Fitting model to feature number 362, F378
## 2025-04-23 17:17:40.241648 INFO::Fitting model to feature number 363, F379
## 2025-04-23 17:17:40.246252 INFO::Fitting model to feature number 364, F380
## 2025-04-23 17:17:40.25202 INFO::Fitting model to feature number 365, F381
## 2025-04-23 17:17:40.257718 INFO::Fitting model to feature number 366, F382
## 2025-04-23 17:17:40.263094 INFO::Fitting model to feature number 367, F383
## 2025-04-23 17:17:40.267624 INFO::Fitting model to feature number 368, F384
## 2025-04-23 17:17:40.272472 INFO::Fitting model to feature number 369, F386
## 2025-04-23 17:17:40.276464 INFO::Fitting model to feature number 370, F387
## 2025-04-23 17:17:40.281946 INFO::Fitting model to feature number 371, F388
## 2025-04-23 17:17:40.287368 INFO::Fitting model to feature number 372, F389
## 2025-04-23 17:17:40.292699 INFO::Fitting model to feature number 373, F390
## 2025-04-23 17:17:40.297668 INFO::Fitting model to feature number 374, F391
## 2025-04-23 17:17:40.302989 INFO::Fitting model to feature number 375, F392
## 2025-04-23 17:17:40.307683 INFO::Fitting model to feature number 376, F393
## 2025-04-23 17:17:40.312523 INFO::Fitting model to feature number 377, F394
## 2025-04-23 17:17:40.317491 INFO::Fitting model to feature number 378, F395
## 2025-04-23 17:17:40.322205 INFO::Fitting model to feature number 379, F396
## 2025-04-23 17:17:40.326553 INFO::Fitting model to feature number 380, F397
## 2025-04-23 17:17:40.330617 INFO::Fitting model to feature number 381, F398
## 2025-04-23 17:17:40.334602 INFO::Fitting model to feature number 382, F399
## 2025-04-23 17:17:40.339777 INFO::Fitting model to feature number 383, F400
## 2025-04-23 17:17:40.344164 INFO::Fitting model to feature number 384, F401
## 2025-04-23 17:17:40.349162 INFO::Fitting model to feature number 385, F402
## 2025-04-23 17:17:40.354705 INFO::Fitting model to feature number 386, F403
## 2025-04-23 17:17:40.359543 INFO::Fitting model to feature number 387, F404
## 2025-04-23 17:17:40.363628 INFO::Fitting model to feature number 388, F406
## 2025-04-23 17:17:40.367961 INFO::Fitting model to feature number 389, F407
## 2025-04-23 17:17:40.372094 INFO::Fitting model to feature number 390, F408
## 2025-04-23 17:17:40.376276 INFO::Fitting model to feature number 391, F409
## 2025-04-23 17:17:40.381249 INFO::Fitting model to feature number 392, F410
## 2025-04-23 17:17:40.386322 INFO::Fitting model to feature number 393, F411
## 2025-04-23 17:17:40.391051 INFO::Fitting model to feature number 394, F412
## 2025-04-23 17:17:40.395134 INFO::Fitting model to feature number 395, F413
## 2025-04-23 17:17:40.400524 INFO::Fitting model to feature number 396, F414
## 2025-04-23 17:17:40.406668 INFO::Fitting model to feature number 397, F415
## 2025-04-23 17:17:40.413184 INFO::Fitting model to feature number 398, F416
## 2025-04-23 17:17:40.418677 INFO::Fitting model to feature number 399, F417
## 2025-04-23 17:17:40.424773 INFO::Fitting model to feature number 400, F418
## 2025-04-23 17:17:40.430541 INFO::Fitting model to feature number 401, F419
## 2025-04-23 17:17:40.436106 INFO::Fitting model to feature number 402, F420
## 2025-04-23 17:17:40.441857 INFO::Fitting model to feature number 403, F421
## 2025-04-23 17:17:40.4464 INFO::Fitting model to feature number 404, F422
## 2025-04-23 17:17:40.451345 INFO::Fitting model to feature number 405, F423
## 2025-04-23 17:17:40.456092 INFO::Fitting model to feature number 406, F425
## 2025-04-23 17:17:40.462458 INFO::Fitting model to feature number 407, F426
## 2025-04-23 17:17:40.468217 INFO::Fitting model to feature number 408, F428
## 2025-04-23 17:17:40.473902 INFO::Fitting model to feature number 409, F429
## 2025-04-23 17:17:40.480047 INFO::Fitting model to feature number 410, F430
## 2025-04-23 17:17:40.487907 INFO::Fitting model to feature number 411, F431
## 2025-04-23 17:17:40.492898 INFO::Fitting model to feature number 412, F432
## 2025-04-23 17:17:40.497891 INFO::Fitting model to feature number 413, F433
## 2025-04-23 17:17:40.502279 INFO::Fitting model to feature number 414, F434
## 2025-04-23 17:17:40.506763 INFO::Fitting model to feature number 415, F435
## 2025-04-23 17:17:40.511048 INFO::Fitting model to feature number 416, F436
## 2025-04-23 17:17:40.516203 INFO::Fitting model to feature number 417, F437
## 2025-04-23 17:17:40.52042 INFO::Fitting model to feature number 418, F438
## 2025-04-23 17:17:40.524239 INFO::Fitting model to feature number 419, F439
## 2025-04-23 17:17:40.528328 INFO::Fitting model to feature number 420, F440
## 2025-04-23 17:17:40.532661 INFO::Fitting model to feature number 421, F441
## 2025-04-23 17:17:40.536811 INFO::Fitting model to feature number 422, F442
## 2025-04-23 17:17:40.541102 INFO::Fitting model to feature number 423, F443
## 2025-04-23 17:17:40.546104 INFO::Fitting model to feature number 424, F444
## 2025-04-23 17:17:40.551359 INFO::Fitting model to feature number 425, F445
## 2025-04-23 17:17:40.557139 INFO::Fitting model to feature number 426, F446
## 2025-04-23 17:17:40.562535 INFO::Fitting model to feature number 427, F447
## 2025-04-23 17:17:40.567499 INFO::Fitting model to feature number 428, F448
## 2025-04-23 17:17:40.573646 INFO::Fitting model to feature number 429, F449
## 2025-04-23 17:17:40.578128 INFO::Fitting model to feature number 430, F450
## 2025-04-23 17:17:40.583346 INFO::Fitting model to feature number 431, F451
## 2025-04-23 17:17:40.589187 INFO::Fitting model to feature number 432, F452
## 2025-04-23 17:17:40.594224 INFO::Fitting model to feature number 433, F454
## 2025-04-23 17:17:40.598623 INFO::Fitting model to feature number 434, F455
## 2025-04-23 17:17:40.602498 INFO::Fitting model to feature number 435, F456
## 2025-04-23 17:17:40.607123 INFO::Fitting model to feature number 436, F457
## 2025-04-23 17:17:40.612827 INFO::Fitting model to feature number 437, F458
## 2025-04-23 17:17:40.617782 INFO::Fitting model to feature number 438, F459
## 2025-04-23 17:17:40.62282 INFO::Fitting model to feature number 439, F461
## 2025-04-23 17:17:40.627901 INFO::Fitting model to feature number 440, F462
## 2025-04-23 17:17:40.633127 INFO::Fitting model to feature number 441, F463
## 2025-04-23 17:17:40.638169 INFO::Fitting model to feature number 442, F464
## 2025-04-23 17:17:40.644112 INFO::Fitting model to feature number 443, F465
## 2025-04-23 17:17:40.64979 INFO::Fitting model to feature number 444, F466
## 2025-04-23 17:17:40.654721 INFO::Fitting model to feature number 445, F467
## 2025-04-23 17:17:40.66012 INFO::Fitting model to feature number 446, F468
## 2025-04-23 17:17:40.664339 INFO::Fitting model to feature number 447, F469
## 2025-04-23 17:17:40.668984 INFO::Fitting model to feature number 448, F470
## 2025-04-23 17:17:40.673756 INFO::Fitting model to feature number 449, F471
## 2025-04-23 17:17:40.678614 INFO::Fitting model to feature number 450, F474
## 2025-04-23 17:17:40.683178 INFO::Fitting model to feature number 451, F475
## 2025-04-23 17:17:40.687836 INFO::Fitting model to feature number 452, F476
## 2025-04-23 17:17:40.69288 INFO::Fitting model to feature number 453, F477
## 2025-04-23 17:17:40.698179 INFO::Fitting model to feature number 454, F478
## 2025-04-23 17:17:40.702228 INFO::Fitting model to feature number 455, F479
## 2025-04-23 17:17:40.706456 INFO::Fitting model to feature number 456, F480
## 2025-04-23 17:17:40.711941 INFO::Fitting model to feature number 457, F481
## 2025-04-23 17:17:40.716883 INFO::Fitting model to feature number 458, F482
## 2025-04-23 17:17:40.722012 INFO::Fitting model to feature number 459, F483
## 2025-04-23 17:17:40.727499 INFO::Fitting model to feature number 460, F484
## 2025-04-23 17:17:40.733 INFO::Fitting model to feature number 461, F485
## 2025-04-23 17:17:40.738016 INFO::Fitting model to feature number 462, F486
## 2025-04-23 17:17:40.74356 INFO::Fitting model to feature number 463, F487
## 2025-04-23 17:17:40.74896 INFO::Fitting model to feature number 464, F488
## 2025-04-23 17:17:40.754761 INFO::Fitting model to feature number 465, F489
## 2025-04-23 17:17:40.759793 INFO::Fitting model to feature number 466, F490
## 2025-04-23 17:17:40.764936 INFO::Fitting model to feature number 467, F491
## 2025-04-23 17:17:40.769283 INFO::Fitting model to feature number 468, F492
## 2025-04-23 17:17:40.773484 INFO::Fitting model to feature number 469, F493
## 2025-04-23 17:17:40.777588 INFO::Fitting model to feature number 470, F494
## 2025-04-23 17:17:40.781912 INFO::Fitting model to feature number 471, F495
## 2025-04-23 17:17:40.786235 INFO::Fitting model to feature number 472, F496
## 2025-04-23 17:17:40.79167 INFO::Fitting model to feature number 473, F497
## 2025-04-23 17:17:40.79692 INFO::Fitting model to feature number 474, F498
## 2025-04-23 17:17:40.801659 INFO::Fitting model to feature number 475, F499
## 2025-04-23 17:17:40.807027 INFO::Fitting model to feature number 476, F500
## 2025-04-23 17:17:40.812531 INFO::Fitting model to feature number 477, F501
## 2025-04-23 17:17:40.818133 INFO::Fitting model to feature number 478, F502
## 2025-04-23 17:17:40.822654 INFO::Fitting model to feature number 479, F503
## 2025-04-23 17:17:40.828141 INFO::Fitting model to feature number 480, F504
## 2025-04-23 17:17:40.83271 INFO::Fitting model to feature number 481, F505
## 2025-04-23 17:17:40.839007 INFO::Fitting model to feature number 482, F506
## 2025-04-23 17:17:40.843926 INFO::Fitting model to feature number 483, F507
## 2025-04-23 17:17:40.849743 INFO::Fitting model to feature number 484, F508
## 2025-04-23 17:17:40.855798 INFO::Fitting model to feature number 485, F509
## 2025-04-23 17:17:40.860924 INFO::Fitting model to feature number 486, F510
## 2025-04-23 17:17:40.865443 INFO::Fitting model to feature number 487, F511
## 2025-04-23 17:17:40.870651 INFO::Fitting model to feature number 488, F512
## 2025-04-23 17:17:40.876654 INFO::Fitting model to feature number 489, F513
## 2025-04-23 17:17:40.882168 INFO::Fitting model to feature number 490, F514
## 2025-04-23 17:17:40.887931 INFO::Fitting model to feature number 491, F515
## 2025-04-23 17:17:40.893917 INFO::Fitting model to feature number 492, F516
## 2025-04-23 17:17:40.898915 INFO::Fitting model to feature number 493, F517
## 2025-04-23 17:17:40.903493 INFO::Fitting model to feature number 494, F518
## 2025-04-23 17:17:40.907616 INFO::Fitting model to feature number 495, F519
## 2025-04-23 17:17:40.911662 INFO::Fitting model to feature number 496, F520
## 2025-04-23 17:17:40.915601 INFO::Fitting model to feature number 497, F521
## 2025-04-23 17:17:40.919468 INFO::Fitting model to feature number 498, F522
## 2025-04-23 17:17:40.923427 INFO::Fitting model to feature number 499, F523
## 2025-04-23 17:17:40.927467 INFO::Fitting model to feature number 500, F524
## 2025-04-23 17:17:40.932883 INFO::Fitting model to feature number 501, F525
## 2025-04-23 17:17:40.938805 INFO::Fitting model to feature number 502, F526
## 2025-04-23 17:17:40.944211 INFO::Fitting model to feature number 503, F527
## 2025-04-23 17:17:40.948487 INFO::Fitting model to feature number 504, F528
## 2025-04-23 17:17:40.953305 INFO::Fitting model to feature number 505, F529
## 2025-04-23 17:17:40.958936 INFO::Fitting model to feature number 506, F530
## 2025-04-23 17:17:40.96431 INFO::Fitting model to feature number 507, F531
## 2025-04-23 17:17:40.969832 INFO::Fitting model to feature number 508, F532
## 2025-04-23 17:17:40.975423 INFO::Fitting model to feature number 509, F533
## 2025-04-23 17:17:40.979675 INFO::Fitting model to feature number 510, F534
## 2025-04-23 17:17:40.984891 INFO::Fitting model to feature number 511, F535
## 2025-04-23 17:17:40.989225 INFO::Fitting model to feature number 512, F536
## 2025-04-23 17:17:40.99382 INFO::Fitting model to feature number 513, F537
## 2025-04-23 17:17:40.998692 INFO::Fitting model to feature number 514, F539
## 2025-04-23 17:17:41.003147 INFO::Fitting model to feature number 515, F540
## 2025-04-23 17:17:41.007232 INFO::Fitting model to feature number 516, F541
## 2025-04-23 17:17:41.012241 INFO::Fitting model to feature number 517, F543
## 2025-04-23 17:17:41.016961 INFO::Fitting model to feature number 518, F544
## 2025-04-23 17:17:41.020786 INFO::Fitting model to feature number 519, F545
## 2025-04-23 17:17:41.026691 INFO::Fitting model to feature number 520, F546
## 2025-04-23 17:17:41.032692 INFO::Fitting model to feature number 521, F547
## 2025-04-23 17:17:41.037895 INFO::Fitting model to feature number 522, F548
## 2025-04-23 17:17:41.043529 INFO::Fitting model to feature number 523, F549
## 2025-04-23 17:17:41.048096 INFO::Fitting model to feature number 524, F550
## 2025-04-23 17:17:41.0533 INFO::Fitting model to feature number 525, F551
## 2025-04-23 17:17:41.058804 INFO::Fitting model to feature number 526, F552
## 2025-04-23 17:17:41.064819 INFO::Fitting model to feature number 527, F553
## 2025-04-23 17:17:41.069646 INFO::Fitting model to feature number 528, F554
## 2025-04-23 17:17:41.074425 INFO::Fitting model to feature number 529, F555
## 2025-04-23 17:17:41.079111 INFO::Fitting model to feature number 530, F556
## 2025-04-23 17:17:41.084032 INFO::Fitting model to feature number 531, F557
## 2025-04-23 17:17:41.088127 INFO::Fitting model to feature number 532, F558
## 2025-04-23 17:17:41.092566 INFO::Fitting model to feature number 533, F559
## 2025-04-23 17:17:41.096589 INFO::Fitting model to feature number 534, F560
## 2025-04-23 17:17:41.10137 INFO::Fitting model to feature number 535, F561
## 2025-04-23 17:17:41.107032 INFO::Fitting model to feature number 536, F562
## 2025-04-23 17:17:41.148496 INFO::Fitting model to feature number 537, F563
## 2025-04-23 17:17:41.153312 INFO::Fitting model to feature number 538, F564
## 2025-04-23 17:17:41.158336 INFO::Fitting model to feature number 539, F566
## 2025-04-23 17:17:41.163172 INFO::Fitting model to feature number 540, F567
## 2025-04-23 17:17:41.167712 INFO::Fitting model to feature number 541, F568
## 2025-04-23 17:17:41.171718 INFO::Fitting model to feature number 542, F569
## 2025-04-23 17:17:41.176833 INFO::Fitting model to feature number 543, F570
## 2025-04-23 17:17:41.180764 INFO::Fitting model to feature number 544, F571
## 2025-04-23 17:17:41.184961 INFO::Fitting model to feature number 545, F572
## 2025-04-23 17:17:41.190079 INFO::Fitting model to feature number 546, F573
## 2025-04-23 17:17:41.194739 INFO::Fitting model to feature number 547, F574
## 2025-04-23 17:17:41.199498 INFO::Fitting model to feature number 548, F575
## 2025-04-23 17:17:41.203941 INFO::Fitting model to feature number 549, F576
## 2025-04-23 17:17:41.20767 INFO::Fitting model to feature number 550, F577
## 2025-04-23 17:17:41.211744 INFO::Fitting model to feature number 551, F578
## 2025-04-23 17:17:41.217087 INFO::Fitting model to feature number 552, F579
## 2025-04-23 17:17:41.221436 INFO::Fitting model to feature number 553, F580
## 2025-04-23 17:17:41.225257 INFO::Fitting model to feature number 554, F581
## 2025-04-23 17:17:41.229109 INFO::Fitting model to feature number 555, F582
## 2025-04-23 17:17:41.23388 INFO::Fitting model to feature number 556, F583
## 2025-04-23 17:17:41.24015 INFO::Fitting model to feature number 557, F584
## 2025-04-23 17:17:41.246551 INFO::Fitting model to feature number 558, F585
## 2025-04-23 17:17:41.251061 INFO::Fitting model to feature number 559, F586
## 2025-04-23 17:17:41.25503 INFO::Fitting model to feature number 560, F587
## 2025-04-23 17:17:41.259016 INFO::Fitting model to feature number 561, F588
## 2025-04-23 17:17:41.26338 INFO::Fitting model to feature number 562, F589
## 2025-04-23 17:17:41.267352 INFO::Fitting model to feature number 563, F590
## 2025-04-23 17:17:41.271155 INFO::Fitting model to feature number 564, F591
## 2025-04-23 17:17:41.274928 INFO::Fitting model to feature number 565, F592
## 2025-04-23 17:17:41.278679 INFO::Fitting model to feature number 566, F593
## 2025-04-23 17:17:41.282795 INFO::Fitting model to feature number 567, F594
## 2025-04-23 17:17:41.286584 INFO::Fitting model to feature number 568, F595
## 2025-04-23 17:17:41.2911 INFO::Fitting model to feature number 569, F596
## 2025-04-23 17:17:41.295677 INFO::Fitting model to feature number 570, F597
## 2025-04-23 17:17:41.300772 INFO::Fitting model to feature number 571, F598
## 2025-04-23 17:17:41.305092 INFO::Fitting model to feature number 572, F599
## 2025-04-23 17:17:41.309154 INFO::Fitting model to feature number 573, F600
## 2025-04-23 17:17:41.313126 INFO::Fitting model to feature number 574, F601
## 2025-04-23 17:17:41.317845 INFO::Fitting model to feature number 575, F602
## 2025-04-23 17:17:41.321781 INFO::Fitting model to feature number 576, F603
## 2025-04-23 17:17:41.325831 INFO::Fitting model to feature number 577, F605
## 2025-04-23 17:17:41.329784 INFO::Fitting model to feature number 578, F606
## 2025-04-23 17:17:41.333618 INFO::Fitting model to feature number 579, F607
## 2025-04-23 17:17:41.337674 INFO::Fitting model to feature number 580, F608
## 2025-04-23 17:17:41.341601 INFO::Fitting model to feature number 581, F609
## 2025-04-23 17:17:41.346094 INFO::Fitting model to feature number 582, F610
## 2025-04-23 17:17:41.350567 INFO::Fitting model to feature number 583, F611
## 2025-04-23 17:17:41.354644 INFO::Fitting model to feature number 584, F612
## 2025-04-23 17:17:41.359424 INFO::Fitting model to feature number 585, F613
## 2025-04-23 17:17:41.364215 INFO::Fitting model to feature number 586, F614
## 2025-04-23 17:17:41.369249 INFO::Fitting model to feature number 587, F615
## 2025-04-23 17:17:41.373974 INFO::Fitting model to feature number 588, F616
## 2025-04-23 17:17:41.37794 INFO::Fitting model to feature number 589, F617
## 2025-04-23 17:17:41.383285 INFO::Fitting model to feature number 590, F618
## 2025-04-23 17:17:41.389035 INFO::Fitting model to feature number 591, F619
## 2025-04-23 17:17:41.393716 INFO::Fitting model to feature number 592, F620
## 2025-04-23 17:17:41.399409 INFO::Fitting model to feature number 593, F621
## 2025-04-23 17:17:41.404493 INFO::Fitting model to feature number 594, F622
## 2025-04-23 17:17:41.409484 INFO::Fitting model to feature number 595, F623
## 2025-04-23 17:17:41.413865 INFO::Fitting model to feature number 596, F624
## 2025-04-23 17:17:41.418046 INFO::Fitting model to feature number 597, F625
## 2025-04-23 17:17:41.42366 INFO::Fitting model to feature number 598, F626
## 2025-04-23 17:17:41.42839 INFO::Fitting model to feature number 599, F627
## 2025-04-23 17:17:41.432336 INFO::Fitting model to feature number 600, F628
## 2025-04-23 17:17:41.436035 INFO::Fitting model to feature number 601, F629
## 2025-04-23 17:17:41.440002 INFO::Fitting model to feature number 602, F630
## 2025-04-23 17:17:41.44416 INFO::Fitting model to feature number 603, F631
## 2025-04-23 17:17:41.448048 INFO::Fitting model to feature number 604, F632
## 2025-04-23 17:17:41.451952 INFO::Fitting model to feature number 605, F633
## 2025-04-23 17:17:41.455879 INFO::Fitting model to feature number 606, F634
## 2025-04-23 17:17:41.460192 INFO::Fitting model to feature number 607, F635
## 2025-04-23 17:17:41.464664 INFO::Fitting model to feature number 608, F636
## 2025-04-23 17:17:41.469091 INFO::Fitting model to feature number 609, F637
## 2025-04-23 17:17:41.473985 INFO::Fitting model to feature number 610, F638
## 2025-04-23 17:17:41.479044 INFO::Fitting model to feature number 611, F639
## 2025-04-23 17:17:41.483151 INFO::Fitting model to feature number 612, F640
## 2025-04-23 17:17:41.487781 INFO::Fitting model to feature number 613, F641
## 2025-04-23 17:17:41.492664 INFO::Fitting model to feature number 614, F642
## 2025-04-23 17:17:41.497762 INFO::Fitting model to feature number 615, F643
## 2025-04-23 17:17:41.502039 INFO::Fitting model to feature number 616, F644
## 2025-04-23 17:17:41.505987 INFO::Fitting model to feature number 617, F645
## 2025-04-23 17:17:41.510698 INFO::Fitting model to feature number 618, F646
## 2025-04-23 17:17:41.514636 INFO::Fitting model to feature number 619, F647
## 2025-04-23 17:17:41.518785 INFO::Fitting model to feature number 620, F648
## 2025-04-23 17:17:41.522798 INFO::Fitting model to feature number 621, F649
## 2025-04-23 17:17:41.527001 INFO::Fitting model to feature number 622, F650
## 2025-04-23 17:17:41.531645 INFO::Fitting model to feature number 623, F651
## 2025-04-23 17:17:41.535338 INFO::Fitting model to feature number 624, F652
## 2025-04-23 17:17:41.539127 INFO::Fitting model to feature number 625, F653
## 2025-04-23 17:17:41.542881 INFO::Fitting model to feature number 626, F654
## 2025-04-23 17:17:41.546549 INFO::Fitting model to feature number 627, F655
## 2025-04-23 17:17:41.550153 INFO::Fitting model to feature number 628, F656
## 2025-04-23 17:17:41.554515 INFO::Fitting model to feature number 629, F657
## 2025-04-23 17:17:41.559055 INFO::Fitting model to feature number 630, F658
## 2025-04-23 17:17:41.562772 INFO::Fitting model to feature number 631, F659
## 2025-04-23 17:17:41.56658 INFO::Fitting model to feature number 632, F660
## 2025-04-23 17:17:41.570623 INFO::Fitting model to feature number 633, F661
## 2025-04-23 17:17:41.574757 INFO::Fitting model to feature number 634, F662
## 2025-04-23 17:17:41.579368 INFO::Fitting model to feature number 635, F663
## 2025-04-23 17:17:41.585101 INFO::Fitting model to feature number 636, F664
## 2025-04-23 17:17:41.591172 INFO::Fitting model to feature number 637, F665
## 2025-04-23 17:17:41.596262 INFO::Fitting model to feature number 638, F666
## 2025-04-23 17:17:41.601522 INFO::Fitting model to feature number 639, F667
## 2025-04-23 17:17:41.606456 INFO::Fitting model to feature number 640, F668
## 2025-04-23 17:17:41.610792 INFO::Fitting model to feature number 641, F669
## 2025-04-23 17:17:41.615239 INFO::Fitting model to feature number 642, F670
## 2025-04-23 17:17:41.619599 INFO::Fitting model to feature number 643, F671
## 2025-04-23 17:17:41.624663 INFO::Fitting model to feature number 644, F672
## 2025-04-23 17:17:41.628791 INFO::Fitting model to feature number 645, F673
## 2025-04-23 17:17:41.634195 INFO::Fitting model to feature number 646, F674
## 2025-04-23 17:17:41.639811 INFO::Fitting model to feature number 647, F675
## 2025-04-23 17:17:41.645353 INFO::Fitting model to feature number 648, F676
## 2025-04-23 17:17:41.649927 INFO::Fitting model to feature number 649, F677
## 2025-04-23 17:17:41.655145 INFO::Fitting model to feature number 650, F678
## 2025-04-23 17:17:41.66026 INFO::Fitting model to feature number 651, F679
## 2025-04-23 17:17:41.665294 INFO::Fitting model to feature number 652, F680
## 2025-04-23 17:17:41.670352 INFO::Fitting model to feature number 653, F681
## 2025-04-23 17:17:41.675105 INFO::Fitting model to feature number 654, F682
## 2025-04-23 17:17:41.680085 INFO::Fitting model to feature number 655, F683
## 2025-04-23 17:17:41.684899 INFO::Fitting model to feature number 656, F684
## 2025-04-23 17:17:41.690283 INFO::Fitting model to feature number 657, F685
## 2025-04-23 17:17:41.694482 INFO::Fitting model to feature number 658, F686
## 2025-04-23 17:17:41.699833 INFO::Fitting model to feature number 659, F687
## 2025-04-23 17:17:41.705823 INFO::Fitting model to feature number 660, F688
## 2025-04-23 17:17:41.711595 INFO::Fitting model to feature number 661, F689
## 2025-04-23 17:17:41.717149 INFO::Fitting model to feature number 662, F690
## 2025-04-23 17:17:41.721503 INFO::Fitting model to feature number 663, F691
## 2025-04-23 17:17:41.726861 INFO::Fitting model to feature number 664, F692
## 2025-04-23 17:17:41.731919 INFO::Fitting model to feature number 665, F693
## 2025-04-23 17:17:41.736061 INFO::Fitting model to feature number 666, F694
## 2025-04-23 17:17:41.740264 INFO::Fitting model to feature number 667, F695
## 2025-04-23 17:17:41.744128 INFO::Fitting model to feature number 668, F696
## 2025-04-23 17:17:41.748148 INFO::Fitting model to feature number 669, F697
## 2025-04-23 17:17:41.753086 INFO::Fitting model to feature number 670, F698
## 2025-04-23 17:17:41.756993 INFO::Fitting model to feature number 671, F699
## 2025-04-23 17:17:41.761194 INFO::Fitting model to feature number 672, F700
## 2025-04-23 17:17:41.76477 INFO::Fitting model to feature number 673, F701
## 2025-04-23 17:17:41.768366 INFO::Fitting model to feature number 674, F702
## 2025-04-23 17:17:41.772203 INFO::Fitting model to feature number 675, F704
## 2025-04-23 17:17:41.77601 INFO::Fitting model to feature number 676, F705
## 2025-04-23 17:17:41.77991 INFO::Fitting model to feature number 677, F706
## 2025-04-23 17:17:41.784028 INFO::Fitting model to feature number 678, F707
## 2025-04-23 17:17:41.789423 INFO::Fitting model to feature number 679, F708
## 2025-04-23 17:17:41.794953 INFO::Fitting model to feature number 680, F709
## 2025-04-23 17:17:41.798806 INFO::Fitting model to feature number 681, F710
## 2025-04-23 17:17:41.804076 INFO::Fitting model to feature number 682, F711
## 2025-04-23 17:17:41.808282 INFO::Fitting model to feature number 683, F712
## 2025-04-23 17:17:41.812448 INFO::Fitting model to feature number 684, F713
## 2025-04-23 17:17:41.816622 INFO::Fitting model to feature number 685, F714
## 2025-04-23 17:17:41.820624 INFO::Fitting model to feature number 686, F715
## 2025-04-23 17:17:41.825846 INFO::Fitting model to feature number 687, F716
## 2025-04-23 17:17:41.830668 INFO::Fitting model to feature number 688, F717
## 2025-04-23 17:17:41.835418 INFO::Fitting model to feature number 689, F718
## 2025-04-23 17:17:41.840647 INFO::Fitting model to feature number 690, F719
## 2025-04-23 17:17:41.845605 INFO::Fitting model to feature number 691, F720
## 2025-04-23 17:17:41.849798 INFO::Fitting model to feature number 692, F721
## 2025-04-23 17:17:41.854562 INFO::Fitting model to feature number 693, F722
## 2025-04-23 17:17:41.860791 INFO::Fitting model to feature number 694, F723
## 2025-04-23 17:17:41.865636 INFO::Fitting model to feature number 695, F724
## 2025-04-23 17:17:41.870417 INFO::Fitting model to feature number 696, F725
## 2025-04-23 17:17:41.875955 INFO::Fitting model to feature number 697, F726
## 2025-04-23 17:17:41.881332 INFO::Fitting model to feature number 698, F727
## 2025-04-23 17:17:41.886021 INFO::Fitting model to feature number 699, F728
## 2025-04-23 17:17:41.890428 INFO::Fitting model to feature number 700, F729
## 2025-04-23 17:17:41.895738 INFO::Fitting model to feature number 701, F730
## 2025-04-23 17:17:41.901373 INFO::Fitting model to feature number 702, F731
## 2025-04-23 17:17:41.906775 INFO::Fitting model to feature number 703, F732
## 2025-04-23 17:17:41.911979 INFO::Fitting model to feature number 704, F733
## 2025-04-23 17:17:41.917337 INFO::Fitting model to feature number 705, F734
## 2025-04-23 17:17:41.923834 INFO::Fitting model to feature number 706, F735
## 2025-04-23 17:17:41.928326 INFO::Fitting model to feature number 707, F736
## 2025-04-23 17:17:41.932577 INFO::Fitting model to feature number 708, F737
## 2025-04-23 17:17:41.938521 INFO::Fitting model to feature number 709, F739
## 2025-04-23 17:17:41.944392 INFO::Fitting model to feature number 710, F740
## 2025-04-23 17:17:41.948764 INFO::Fitting model to feature number 711, F741
## 2025-04-23 17:17:41.954178 INFO::Fitting model to feature number 712, F742
## 2025-04-23 17:17:41.959385 INFO::Fitting model to feature number 713, F743
## 2025-04-23 17:17:41.96396 INFO::Fitting model to feature number 714, F744
## 2025-04-23 17:17:41.968965 INFO::Fitting model to feature number 715, F745
## 2025-04-23 17:17:41.973901 INFO::Fitting model to feature number 716, F746
## 2025-04-23 17:17:41.978155 INFO::Fitting model to feature number 717, F747
## 2025-04-23 17:17:41.982421 INFO::Fitting model to feature number 718, F748
## 2025-04-23 17:17:41.986811 INFO::Fitting model to feature number 719, F749
## 2025-04-23 17:17:41.99133 INFO::Fitting model to feature number 720, F750
## 2025-04-23 17:17:41.999019 INFO::Fitting model to feature number 721, F751
## 2025-04-23 17:17:42.003241 INFO::Fitting model to feature number 722, F752
## 2025-04-23 17:17:42.007792 INFO::Fitting model to feature number 723, F753
## 2025-04-23 17:17:42.011742 INFO::Fitting model to feature number 724, F754
## 2025-04-23 17:17:42.015814 INFO::Fitting model to feature number 725, F755
## 2025-04-23 17:17:42.020162 INFO::Fitting model to feature number 726, F756
## 2025-04-23 17:17:42.024285 INFO::Fitting model to feature number 727, F757
## 2025-04-23 17:17:42.028222 INFO::Fitting model to feature number 728, F758
## 2025-04-23 17:17:42.032315 INFO::Fitting model to feature number 729, F759
## 2025-04-23 17:17:42.036359 INFO::Fitting model to feature number 730, F760
## 2025-04-23 17:17:42.040826 INFO::Fitting model to feature number 731, F761
## 2025-04-23 17:17:42.045704 INFO::Fitting model to feature number 732, F762
## 2025-04-23 17:17:42.050427 INFO::Fitting model to feature number 733, F763
## 2025-04-23 17:17:42.054581 INFO::Fitting model to feature number 734, F764
## 2025-04-23 17:17:42.059344 INFO::Fitting model to feature number 735, F765
## 2025-04-23 17:17:42.063126 INFO::Fitting model to feature number 736, F766
## 2025-04-23 17:17:42.066984 INFO::Fitting model to feature number 737, F767
## 2025-04-23 17:17:42.073062 INFO::Fitting model to feature number 738, F768
## 2025-04-23 17:17:42.078347 INFO::Fitting model to feature number 739, F769
## 2025-04-23 17:17:42.082966 INFO::Fitting model to feature number 740, F770
## 2025-04-23 17:17:42.088335 INFO::Fitting model to feature number 741, F771
## 2025-04-23 17:17:42.093214 INFO::Fitting model to feature number 742, F772
## 2025-04-23 17:17:42.097659 INFO::Fitting model to feature number 743, F773
## 2025-04-23 17:17:42.103281 INFO::Fitting model to feature number 744, F774
## 2025-04-23 17:17:42.108944 INFO::Fitting model to feature number 745, F775
## 2025-04-23 17:17:42.114671 INFO::Fitting model to feature number 746, F776
## 2025-04-23 17:17:42.119972 INFO::Fitting model to feature number 747, F777
## 2025-04-23 17:17:42.124539 INFO::Fitting model to feature number 748, F778
## 2025-04-23 17:17:42.128717 INFO::Fitting model to feature number 749, F779
## 2025-04-23 17:17:42.132909 INFO::Fitting model to feature number 750, F780
## 2025-04-23 17:17:42.137248 INFO::Fitting model to feature number 751, F781
## 2025-04-23 17:17:42.141061 INFO::Fitting model to feature number 752, F782
## 2025-04-23 17:17:42.145134 INFO::Fitting model to feature number 753, F783
## 2025-04-23 17:17:42.149436 INFO::Fitting model to feature number 754, F784
## 2025-04-23 17:17:42.154962 INFO::Fitting model to feature number 755, F785
## 2025-04-23 17:17:42.159594 INFO::Fitting model to feature number 756, F786
## 2025-04-23 17:17:42.163952 INFO::Fitting model to feature number 757, F787
## 2025-04-23 17:17:42.168444 INFO::Fitting model to feature number 758, F788
## 2025-04-23 17:17:42.17213 INFO::Fitting model to feature number 759, F789
## 2025-04-23 17:17:42.175848 INFO::Fitting model to feature number 760, F790
## 2025-04-23 17:17:42.179671 INFO::Fitting model to feature number 761, F791
## 2025-04-23 17:17:42.183918 INFO::Fitting model to feature number 762, F792
## 2025-04-23 17:17:42.189427 INFO::Fitting model to feature number 763, F793
## 2025-04-23 17:17:42.195153 INFO::Fitting model to feature number 764, F794
## 2025-04-23 17:17:42.199898 INFO::Fitting model to feature number 765, F795
## 2025-04-23 17:17:42.204265 INFO::Fitting model to feature number 766, F796
## 2025-04-23 17:17:42.208218 INFO::Fitting model to feature number 767, F797
## 2025-04-23 17:17:42.212453 INFO::Fitting model to feature number 768, F798
## 2025-04-23 17:17:42.217298 INFO::Fitting model to feature number 769, F799
## 2025-04-23 17:17:42.221614 INFO::Fitting model to feature number 770, F800
## 2025-04-23 17:17:42.227186 INFO::Fitting model to feature number 771, F801
## 2025-04-23 17:17:42.232748 INFO::Fitting model to feature number 772, F802
## 2025-04-23 17:17:42.23785 INFO::Fitting model to feature number 773, F803
## 2025-04-23 17:17:42.242769 INFO::Fitting model to feature number 774, F804
## 2025-04-23 17:17:42.248068 INFO::Fitting model to feature number 775, F805
## 2025-04-23 17:17:42.254 INFO::Fitting model to feature number 776, F806
## 2025-04-23 17:17:42.258035 INFO::Fitting model to feature number 777, F808
## 2025-04-23 17:17:42.262987 INFO::Fitting model to feature number 778, F809
## 2025-04-23 17:17:42.26821 INFO::Fitting model to feature number 779, F810
## 2025-04-23 17:17:42.273308 INFO::Fitting model to feature number 780, F811
## 2025-04-23 17:17:42.27842 INFO::Fitting model to feature number 781, F812
## 2025-04-23 17:17:42.283538 INFO::Fitting model to feature number 782, F813
## 2025-04-23 17:17:42.288644 INFO::Fitting model to feature number 783, F814
## 2025-04-23 17:17:42.294308 INFO::Fitting model to feature number 784, F815
## 2025-04-23 17:17:42.29945 INFO::Fitting model to feature number 785, F816
## 2025-04-23 17:17:42.304291 INFO::Fitting model to feature number 786, F817
## 2025-04-23 17:17:42.308925 INFO::Fitting model to feature number 787, F818
## 2025-04-23 17:17:42.314344 INFO::Fitting model to feature number 788, F819
## 2025-04-23 17:17:42.31961 INFO::Fitting model to feature number 789, F820
## 2025-04-23 17:17:42.324898 INFO::Fitting model to feature number 790, F821
## 2025-04-23 17:17:42.330252 INFO::Fitting model to feature number 791, F822
## 2025-04-23 17:17:42.335098 INFO::Fitting model to feature number 792, F823
## 2025-04-23 17:17:42.340376 INFO::Fitting model to feature number 793, F824
## 2025-04-23 17:17:42.345552 INFO::Fitting model to feature number 794, F825
## 2025-04-23 17:17:42.350523 INFO::Fitting model to feature number 795, F826
## 2025-04-23 17:17:42.3558 INFO::Fitting model to feature number 796, F827
## 2025-04-23 17:17:42.361016 INFO::Fitting model to feature number 797, F828
## 2025-04-23 17:17:42.36587 INFO::Fitting model to feature number 798, F829
## 2025-04-23 17:17:42.370451 INFO::Fitting model to feature number 799, F830
## 2025-04-23 17:17:42.376385 INFO::Fitting model to feature number 800, F831
## 2025-04-23 17:17:42.382167 INFO::Fitting model to feature number 801, F832
## 2025-04-23 17:17:42.387993 INFO::Fitting model to feature number 802, F833
## 2025-04-23 17:17:42.393483 INFO::Fitting model to feature number 803, F834
## 2025-04-23 17:17:42.398024 INFO::Fitting model to feature number 804, F835
## 2025-04-23 17:17:42.401807 INFO::Fitting model to feature number 805, F836
## 2025-04-23 17:17:42.405992 INFO::Fitting model to feature number 806, F837
## 2025-04-23 17:17:42.410915 INFO::Fitting model to feature number 807, F838
## 2025-04-23 17:17:42.415557 INFO::Fitting model to feature number 808, F839
## 2025-04-23 17:17:42.420596 INFO::Fitting model to feature number 809, F840
## 2025-04-23 17:17:42.425299 INFO::Fitting model to feature number 810, F841
## 2025-04-23 17:17:42.430206 INFO::Fitting model to feature number 811, F842
## 2025-04-23 17:17:42.435011 INFO::Fitting model to feature number 812, F843
## 2025-04-23 17:17:42.439384 INFO::Fitting model to feature number 813, F844
## 2025-04-23 17:17:42.444654 INFO::Fitting model to feature number 814, F845
## 2025-04-23 17:17:42.449771 INFO::Fitting model to feature number 815, F846
## 2025-04-23 17:17:42.455496 INFO::Fitting model to feature number 816, F847
## 2025-04-23 17:17:42.461121 INFO::Fitting model to feature number 817, F848
## 2025-04-23 17:17:42.465559 INFO::Fitting model to feature number 818, F849
## 2025-04-23 17:17:42.471063 INFO::Fitting model to feature number 819, F850
## 2025-04-23 17:17:42.476522 INFO::Fitting model to feature number 820, F851
## 2025-04-23 17:17:42.481823 INFO::Fitting model to feature number 821, F852
## 2025-04-23 17:17:42.486091 INFO::Fitting model to feature number 822, F853
## 2025-04-23 17:17:42.491969 INFO::Fitting model to feature number 823, F854
## 2025-04-23 17:17:42.497619 INFO::Fitting model to feature number 824, F855
## 2025-04-23 17:17:42.503131 INFO::Fitting model to feature number 825, F856
## 2025-04-23 17:17:42.50764 INFO::Fitting model to feature number 826, F857
## 2025-04-23 17:17:42.511513 INFO::Fitting model to feature number 827, F858
## 2025-04-23 17:17:42.515233 INFO::Fitting model to feature number 828, F859
## 2025-04-23 17:17:42.519281 INFO::Fitting model to feature number 829, F860
## 2025-04-23 17:17:42.5252 INFO::Fitting model to feature number 830, F861
## 2025-04-23 17:17:42.530932 INFO::Fitting model to feature number 831, F862
## 2025-04-23 17:17:42.535696 INFO::Fitting model to feature number 832, F863
## 2025-04-23 17:17:42.53972 INFO::Fitting model to feature number 833, F864
## 2025-04-23 17:17:42.543504 INFO::Fitting model to feature number 834, F865
## 2025-04-23 17:17:42.547343 INFO::Fitting model to feature number 835, F866
## 2025-04-23 17:17:42.551406 INFO::Fitting model to feature number 836, F867
## 2025-04-23 17:17:42.555312 INFO::Fitting model to feature number 837, F868
## 2025-04-23 17:17:42.560111 INFO::Fitting model to feature number 838, F869
## 2025-04-23 17:17:42.564421 INFO::Fitting model to feature number 839, F870
## 2025-04-23 17:17:42.569023 INFO::Fitting model to feature number 840, F871
## 2025-04-23 17:17:42.573567 INFO::Fitting model to feature number 841, F872
## 2025-04-23 17:17:42.577981 INFO::Fitting model to feature number 842, F873
## 2025-04-23 17:17:42.583258 INFO::Fitting model to feature number 843, F874
## 2025-04-23 17:17:42.58892 INFO::Fitting model to feature number 844, F875
## 2025-04-23 17:17:42.594299 INFO::Fitting model to feature number 845, F876
## 2025-04-23 17:17:42.598488 INFO::Fitting model to feature number 846, F877
## 2025-04-23 17:17:42.602736 INFO::Fitting model to feature number 847, F878
## 2025-04-23 17:17:42.609031 INFO::Fitting model to feature number 848, F879
## 2025-04-23 17:17:42.615393 INFO::Fitting model to feature number 849, F880
## 2025-04-23 17:17:42.620726 INFO::Fitting model to feature number 850, F881
## 2025-04-23 17:17:42.625619 INFO::Fitting model to feature number 851, F882
## 2025-04-23 17:17:42.630631 INFO::Fitting model to feature number 852, F883
## 2025-04-23 17:17:42.671342 INFO::Fitting model to feature number 853, F884
## 2025-04-23 17:17:42.675487 INFO::Fitting model to feature number 854, F885
## 2025-04-23 17:17:42.679797 INFO::Fitting model to feature number 855, F886
## 2025-04-23 17:17:42.683786 INFO::Fitting model to feature number 856, F887
## 2025-04-23 17:17:42.688614 INFO::Fitting model to feature number 857, F888
## 2025-04-23 17:17:42.692752 INFO::Fitting model to feature number 858, F889
## 2025-04-23 17:17:42.696409 INFO::Fitting model to feature number 859, F890
## 2025-04-23 17:17:42.700042 INFO::Fitting model to feature number 860, F891
## 2025-04-23 17:17:42.703681 INFO::Fitting model to feature number 861, F892
## 2025-04-23 17:17:42.708226 INFO::Fitting model to feature number 862, F893
## 2025-04-23 17:17:42.712513 INFO::Fitting model to feature number 863, F894
## 2025-04-23 17:17:42.715952 INFO::Fitting model to feature number 864, F895
## 2025-04-23 17:17:42.720911 INFO::Fitting model to feature number 865, F896
## 2025-04-23 17:17:42.726327 INFO::Fitting model to feature number 866, F897
## 2025-04-23 17:17:42.731906 INFO::Fitting model to feature number 867, F898
## 2025-04-23 17:17:42.736595 INFO::Fitting model to feature number 868, F899
## 2025-04-23 17:17:42.740453 INFO::Fitting model to feature number 869, F900
## 2025-04-23 17:17:42.912753 INFO::Counting total values for each feature
## 2025-04-23 17:17:43.049053 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2025-04-23 17:17:43.175168 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2025-04-23 17:17:43.303535 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2025-04-23 17:17:43.417995 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2025-04-23 17:17:43.464548 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2025-04-23 17:17:43.501676 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2025-04-23 17:17:43.52971 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2025-04-23 17:17:43.540236 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2025-04-23 17:17:43.559792 INFO::Plotting associations from most to least significant, grouped by metadata
## 2025-04-23 17:17:43.561028 INFO::Plotting data for metadata number 1, diagnosis
## 2025-04-23 17:17:43.609053 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2025-04-23 17:17:43.965072 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2025-04-23 17:17:44.213639 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2025-04-23 17:17:44.452689 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2025-04-23 17:17:44.671917 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2025-04-23 17:17:44.861239 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2025-04-23 17:17:45.050837 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2025-04-23 17:17:45.248776 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2025-04-23 17:17:45.438967 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2025-04-23 17:17:45.63424 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2025-04-23 17:17:45.830497 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2025-04-23 17:17:46.025925 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2025-04-23 17:17:46.22129 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2025-04-23 17:17:46.438431 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2025-04-23 17:17:46.630787 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2025-04-23 17:17:46.837406 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2025-04-23 17:17:47.019472 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2025-04-23 17:17:47.221957 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2025-04-23 17:17:47.448868 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2025-04-23 17:17:47.621024 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2025-04-23 17:17:47.840527 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2025-04-23 17:17:48.059405 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2025-04-23 17:17:48.258081 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2025-04-23 17:17:48.531055 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2025-04-23 17:17:48.733219 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2025-04-23 17:17:48.959514 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2025-04-23 17:17:49.180421 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2025-04-23 17:17:49.381165 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2025-04-23 17:17:49.602104 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2025-04-23 17:17:49.800679 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2025-04-23 17:17:49.976105 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2025-04-23 17:17:50.178174 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2025-04-23 17:17:50.370352 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2025-04-23 17:17:50.565188 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2025-04-23 17:17:50.721707 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2025-04-23 17:17:50.895344 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2025-04-23 17:17:51.093 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2025-04-23 17:17:51.289254 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2025-04-23 17:17:51.531407 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2025-04-23 17:17:51.734629 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2025-04-23 17:17:51.939296 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2025-04-23 17:17:52.145404 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2025-04-23 17:17:52.347349 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2025-04-23 17:17:52.554318 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2025-04-23 17:17:52.738768 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2025-04-23 17:17:52.911754 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2025-04-23 17:17:53.089816 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2025-04-23 17:17:53.26944 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2025-04-23 17:17:53.495243 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2025-04-23 17:17:53.685582 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2025-04-23 17:17:53.92029 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2025-04-23 17:17:54.106022 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2025-04-23 17:17:54.308698 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2025-04-23 17:17:54.518229 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2025-04-23 17:17:54.712387 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2025-04-23 17:17:54.931632 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2025-04-23 17:17:55.133494 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2025-04-23 17:17:55.336379 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2025-04-23 17:17:55.535786 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2025-04-23 17:17:55.74418 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2025-04-23 17:17:55.940329 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2025-04-23 17:17:56.122323 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2025-04-23 17:17:56.321021 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2025-04-23 17:17:56.48961 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2025-04-23 17:17:56.663769 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2025-04-23 17:17:56.850937 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2025-04-23 17:17:57.039807 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2025-04-23 17:17:57.248122 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2025-04-23 17:17:57.435936 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2025-04-23 17:17:57.636862 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2025-04-23 17:17:57.817921 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2025-04-23 17:17:58.02934 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2025-04-23 17:17:58.247279 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2025-04-23 17:17:58.453334 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2025-04-23 17:17:58.674308 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2025-04-23 17:17:58.895781 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2025-04-23 17:17:59.104731 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2025-04-23 17:17:59.342043 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2025-04-23 17:17:59.54469 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2025-04-23 17:17:59.758109 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2025-04-23 17:17:59.977164 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2025-04-23 17:18:00.1926 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2025-04-23 17:18:00.394098 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2025-04-23 17:18:00.578215 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2025-04-23 17:18:00.765007 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2025-04-23 17:18:00.98776 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2025-04-23 17:18:01.194313 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2025-04-23 17:18:01.397973 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2025-04-23 17:18:01.577706 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2025-04-23 17:18:01.75568 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2025-04-23 17:18:01.936815 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2025-04-23 17:18:02.132647 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2025-04-23 17:18:02.33289 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2025-04-23 17:18:02.530645 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2025-04-23 17:18:02.737112 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2025-04-23 17:18:02.937775 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2025-04-23 17:18:03.132559 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2025-04-23 17:18:03.351248 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2025-04-23 17:18:03.546771 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2025-04-23 17:18:03.754013 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2025-04-23 17:18:03.953852 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2025-04-23 17:18:04.166477 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2025-04-23 17:18:04.374104 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2025-04-23 17:18:04.565632 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2025-04-23 17:18:04.787404 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2025-04-23 17:18:04.990745 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2025-04-23 17:18:05.21157 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2025-04-23 17:18:05.421401 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2025-04-23 17:18:05.609466 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2025-04-23 17:18:05.805962 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2025-04-23 17:18:06.015647 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2025-04-23 17:18:06.221652 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2025-04-23 17:18:06.434953 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2025-04-23 17:18:06.638549 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2025-04-23 17:18:06.850708 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2025-04-23 17:18:07.067513 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2025-04-23 17:18:07.27082 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2025-04-23 17:18:07.467995 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2025-04-23 17:18:07.6839 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2025-04-23 17:18:07.890373 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2025-04-23 17:18:08.107248 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2025-04-23 17:18:08.325496 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2025-04-23 17:18:08.517631 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2025-04-23 17:18:08.719038 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2025-04-23 17:18:08.935114 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2025-04-23 17:18:09.212701 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2025-04-23 17:18:09.413798 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2025-04-23 17:18:09.617935 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2025-04-23 17:18:09.846278 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2025-04-23 17:18:10.065344 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2025-04-23 17:18:10.318381 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2025-04-23 17:18:10.536587 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2025-04-23 17:18:10.782 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2025-04-23 17:18:11.02726 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2025-04-23 17:18:11.23949 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2025-04-23 17:18:11.464671 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2025-04-23 17:18:11.674144 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2025-04-23 17:18:11.870364 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2025-04-23 17:18:12.083662 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2025-04-23 17:18:12.292588 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2025-04-23 17:18:12.486422 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2025-04-23 17:18:12.691904 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2025-04-23 17:18:12.905985 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2025-04-23 17:18:13.127383 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2025-04-23 17:18:13.346215 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2025-04-23 17:18:13.572378 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2025-04-23 17:18:13.781239 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2025-04-23 17:18:14.002682 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2025-04-23 17:18:14.223044 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2025-04-23 17:18:14.439832 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2025-04-23 17:18:14.666225 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2025-04-23 17:18:14.871627 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2025-04-23 17:18:15.078407 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2025-04-23 17:18:15.276733 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2025-04-23 17:18:15.475664 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2025-04-23 17:18:15.714572 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2025-04-23 17:18:15.904443 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2025-04-23 17:18:16.09563 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2025-04-23 17:18:16.303786 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2025-04-23 17:18:16.507843 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2025-04-23 17:18:16.756031 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2025-04-23 17:18:16.974243 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2025-04-23 17:18:17.185606 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2025-04-23 17:18:17.396679 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2025-04-23 17:18:17.602023 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2025-04-23 17:18:17.841607 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2025-04-23 17:18:18.046531 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2025-04-23 17:18:18.245928 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2025-04-23 17:18:18.456415 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2025-04-23 17:18:18.676966 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2025-04-23 17:18:18.90681 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2025-04-23 17:18:19.118037 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2025-04-23 17:18:19.333786 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2025-04-23 17:18:19.545057 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2025-04-23 17:18:19.76489 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2025-04-23 17:18:19.994677 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2025-04-23 17:18:20.187401 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2025-04-23 17:18:20.383798 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2025-04-23 17:18:20.586922 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2025-04-23 17:18:20.794042 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2025-04-23 17:18:21.004625 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2025-04-23 17:18:21.212874 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2025-04-23 17:18:21.439306 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2025-04-23 17:18:21.65678 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2025-04-23 17:18:21.875336 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2025-04-23 17:18:22.09004 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2025-04-23 17:18:22.300602 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2025-04-23 17:18:22.519915 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2025-04-23 17:18:22.712787 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2025-04-23 17:18:22.919639 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2025-04-23 17:18:23.115399 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2025-04-23 17:18:23.312193 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2025-04-23 17:18:23.531206 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2025-04-23 17:18:23.740005 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2025-04-23 17:18:23.947164 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2025-04-23 17:18:24.146135 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2025-04-23 17:18:24.334693 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2025-04-23 17:18:24.549323 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2025-04-23 17:18:24.76133 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2025-04-23 17:18:24.975679 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2025-04-23 17:18:25.152126 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2025-04-23 17:18:25.335019 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2025-04-23 17:18:25.513799 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2025-04-23 17:18:25.71749 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2025-04-23 17:18:25.910317 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2025-04-23 17:18:26.097303 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2025-04-23 17:18:26.286507 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2025-04-23 17:18:26.472113 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2025-04-23 17:18:26.660816 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2025-04-23 17:18:26.854022 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2025-04-23 17:18:27.039754 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2025-04-23 17:18:27.230074 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2025-04-23 17:18:27.471969 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2025-04-23 17:18:27.690737 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2025-04-23 17:18:27.906095 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2025-04-23 17:18:28.103576 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2025-04-23 17:18:28.292074 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2025-04-23 17:18:28.493158 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2025-04-23 17:18:28.723831 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2025-04-23 17:18:28.912991 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2025-04-23 17:18:29.096071 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2025-04-23 17:18:29.274834 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2025-04-23 17:18:29.443528 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2025-04-23 17:18:29.639203 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2025-04-23 17:18:29.808808 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2025-04-23 17:18:29.979841 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2025-04-23 17:18:30.179316 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2025-04-23 17:18:30.387244 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2025-04-23 17:18:30.665592 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2025-04-23 17:18:30.873949 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2025-04-23 17:18:31.077819 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2025-04-23 17:18:31.28245 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2025-04-23 17:18:31.493644 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2025-04-23 17:18:31.744071 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2025-04-23 17:18:31.997383 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2025-04-23 17:18:32.220948 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2025-04-23 17:18:32.429131 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2025-04-23 17:18:32.647388 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2025-04-23 17:18:32.865539 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2025-04-23 17:18:33.069794 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2025-04-23 17:18:33.257515 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2025-04-23 17:18:33.443105 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2025-04-23 17:18:33.648787 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2025-04-23 17:18:33.879226 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2025-04-23 17:18:34.083599 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2025-04-23 17:18:34.279106 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2025-04-23 17:18:34.48842 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2025-04-23 17:18:34.708905 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2025-04-23 17:18:34.900474 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2025-04-23 17:18:35.105662 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2025-04-23 17:18:35.307621 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2025-04-23 17:18:35.488174 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2025-04-23 17:18:35.702503 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2025-04-23 17:18:35.914101 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2025-04-23 17:18:36.124345 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2025-04-23 17:18:36.341461 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2025-04-23 17:18:36.52889 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2025-04-23 17:18:36.763621 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2025-04-23 17:18:36.968638 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2025-04-23 17:18:37.164313 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2025-04-23 17:18:37.372663 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2025-04-23 17:18:37.57155 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2025-04-23 17:18:37.804899 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2025-04-23 17:18:38.009203 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2025-04-23 17:18:38.209111 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2025-04-23 17:18:38.401202 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2025-04-23 17:18:38.595228 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2025-04-23 17:18:38.792295 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2025-04-23 17:18:38.997683 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2025-04-23 17:18:39.199825 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2025-04-23 17:18:39.404672 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2025-04-23 17:18:39.604185 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2025-04-23 17:18:39.836698 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2025-04-23 17:18:40.06314 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2025-04-23 17:18:40.259013 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2025-04-23 17:18:40.461838 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2025-04-23 17:18:40.648711 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2025-04-23 17:18:40.884598 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2025-04-23 17:18:41.084029 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2025-04-23 17:18:41.290129 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2025-04-23 17:18:41.496111 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2025-04-23 17:18:41.704382 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2025-04-23 17:18:41.945269 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2025-04-23 17:18:42.156171 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2025-04-23 17:18:42.361801 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2025-04-23 17:18:42.552132 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2025-04-23 17:18:42.752478 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2025-04-23 17:18:42.966011 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2025-04-23 17:18:43.150263 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2025-04-23 17:18:43.365751 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2025-04-23 17:18:43.611736 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2025-04-23 17:18:43.847721 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2025-04-23 17:18:44.05883 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2025-04-23 17:18:44.282191 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2025-04-23 17:18:44.511435 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2025-04-23 17:18:44.718321 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2025-04-23 17:18:44.96273 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2025-04-23 17:18:45.175845 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2025-04-23 17:18:45.403551 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2025-04-23 17:18:45.623618 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2025-04-23 17:18:45.825051 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2025-04-23 17:18:46.076645 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2025-04-23 17:18:46.303971 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2025-04-23 17:18:46.537822 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2025-04-23 17:18:46.778044 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2025-04-23 17:18:47.000582 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2025-04-23 17:18:47.2306 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2025-04-23 17:18:47.440175 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2025-04-23 17:18:47.658822 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2025-04-23 17:18:47.870176 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2025-04-23 17:18:48.09748 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2025-04-23 17:18:48.347571 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2025-04-23 17:18:48.561721 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2025-04-23 17:18:48.782459 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2025-04-23 17:18:49.006327 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2025-04-23 17:18:49.257636 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2025-04-23 17:18:49.47062 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2025-04-23 17:18:49.689915 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2025-04-23 17:18:49.914148 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2025-04-23 17:18:50.116281 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2025-04-23 17:18:50.356208 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2025-04-23 17:18:50.568003 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2025-04-23 17:18:50.769207 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2025-04-23 17:18:50.976283 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2025-04-23 17:18:51.200185 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2025-04-23 17:18:51.441584 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2025-04-23 17:18:51.639798 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2025-04-23 17:18:51.844942 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2025-04-23 17:18:52.059103 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2025-04-23 17:18:52.268314 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2025-04-23 17:18:53.210169 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2025-04-23 17:18:53.421704 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2025-04-23 17:18:53.633322 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2025-04-23 17:18:53.85157 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2025-04-23 17:18:54.074941 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2025-04-23 17:18:54.31303 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2025-04-23 17:18:54.518927 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2025-04-23 17:18:54.729232 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2025-04-23 17:18:54.949 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2025-04-23 17:18:55.167078 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2025-04-23 17:18:55.381113 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2025-04-23 17:18:55.585754 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2025-04-23 17:18:55.773679 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2025-04-23 17:18:55.978343 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2025-04-23 17:18:56.16409 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2025-04-23 17:18:56.361193 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2025-04-23 17:18:56.558114 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2025-04-23 17:18:56.75184 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2025-04-23 17:18:56.953013 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2025-04-23 17:18:57.153881 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2025-04-23 17:18:57.343981 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2025-04-23 17:18:57.512568 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2025-04-23 17:18:57.684204 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2025-04-23 17:18:57.862568 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2025-04-23 17:18:58.028324 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2025-04-23 17:18:58.215445 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2025-04-23 17:18:58.406187 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2025-04-23 17:18:58.597435 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2025-04-23 17:18:58.801304 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2025-04-23 17:18:59.025798 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2025-04-23 17:18:59.23546 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2025-04-23 17:18:59.427146 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2025-04-23 17:18:59.618167 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2025-04-23 17:18:59.787733 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2025-04-23 17:18:59.969894 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2025-04-23 17:19:00.161708 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2025-04-23 17:19:00.34816 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2025-04-23 17:19:00.526087 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2025-04-23 17:19:00.741336 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2025-04-23 17:19:00.962316 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2025-04-23 17:19:01.162532 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2025-04-23 17:19:01.348584 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2025-04-23 17:19:01.548939 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2025-04-23 17:19:01.751797 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2025-04-23 17:19:01.971121 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2025-04-23 17:19:02.165846 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2025-04-23 17:19:02.365729 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2025-04-23 17:19:02.541128 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2025-04-23 17:19:02.729475 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2025-04-23 17:19:02.939057 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2025-04-23 17:19:03.100739 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2025-04-23 17:19:03.272125 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2025-04-23 17:19:03.446322 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2025-04-23 17:19:03.63107 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2025-04-23 17:19:03.827758 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2025-04-23 17:19:04.004643 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2025-04-23 17:19:04.189967 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2025-04-23 17:19:04.383908 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2025-04-23 17:19:04.584643 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2025-04-23 17:19:04.791679 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2025-04-23 17:19:04.976406 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2025-04-23 17:19:05.154275 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2025-04-23 17:19:05.352167 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2025-04-23 17:19:05.538722 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2025-04-23 17:19:05.758942 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2025-04-23 17:19:05.991307 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2025-04-23 17:19:06.207351 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2025-04-23 17:19:06.418386 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2025-04-23 17:19:06.636777 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2025-04-23 17:19:06.862508 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2025-04-23 17:19:07.058607 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2025-04-23 17:19:07.252148 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2025-04-23 17:19:07.476132 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2025-04-23 17:19:07.683593 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2025-04-23 17:19:07.891605 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2025-04-23 17:19:08.090283 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2025-04-23 17:19:08.292275 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2025-04-23 17:19:08.512527 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2025-04-23 17:19:08.710706 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2025-04-23 17:19:08.9211 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2025-04-23 17:19:09.131897 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2025-04-23 17:19:09.336453 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2025-04-23 17:19:09.538358 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2025-04-23 17:19:09.763564 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2025-04-23 17:19:09.943745 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2025-04-23 17:19:10.141193 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2025-04-23 17:19:10.313537 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2025-04-23 17:19:10.468556 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2025-04-23 17:19:10.680483 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2025-04-23 17:19:10.865252 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2025-04-23 17:19:11.05428 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2025-04-23 17:19:11.25969 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2025-04-23 17:19:11.475517 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2025-04-23 17:19:11.702024 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2025-04-23 17:19:11.892591 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2025-04-23 17:19:12.075856 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2025-04-23 17:19:12.272049 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2025-04-23 17:19:12.475663 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2025-04-23 17:19:12.688778 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2025-04-23 17:19:12.880422 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2025-04-23 17:19:13.072296 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2025-04-23 17:19:13.264174 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2025-04-23 17:19:13.477185 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2025-04-23 17:19:13.736672 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2025-04-23 17:19:13.915415 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2025-04-23 17:19:14.086241 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2025-04-23 17:19:14.268596 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2025-04-23 17:19:14.446327 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2025-04-23 17:19:14.637565 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2025-04-23 17:19:14.81558 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2025-04-23 17:19:14.995069 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2025-04-23 17:19:15.200929 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2025-04-23 17:19:15.391591 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2025-04-23 17:19:15.590996 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2025-04-23 17:19:15.770089 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2025-04-23 17:19:15.960159 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2025-04-23 17:19:16.162589 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2025-04-23 17:19:16.360045 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2025-04-23 17:19:16.579804 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2025-04-23 17:19:16.788924 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2025-04-23 17:19:16.982956 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2025-04-23 17:19:17.178151 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2025-04-23 17:19:17.371908 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2025-04-23 17:19:17.593659 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2025-04-23 17:19:17.770322 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2025-04-23 17:19:17.956407 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2025-04-23 17:19:18.156568 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2025-04-23 17:19:18.337157 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2025-04-23 17:19:18.528264 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2025-04-23 17:19:18.703932 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2025-04-23 17:19:18.878144 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2025-04-23 17:19:19.060272 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2025-04-23 17:19:19.253218 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2025-04-23 17:19:19.444964 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2025-04-23 17:19:19.613635 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2025-04-23 17:19:19.810548 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2025-04-23 17:19:20.008337 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2025-04-23 17:19:20.235809 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2025-04-23 17:19:20.446999 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2025-04-23 17:19:20.643953 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2025-04-23 17:19:20.844498 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2025-04-23 17:19:21.038769 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2025-04-23 17:19:21.2581 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2025-04-23 17:19:21.454569 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2025-04-23 17:19:21.632749 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2025-04-23 17:19:21.821164 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2025-04-23 17:19:22.032251 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2025-04-23 17:19:22.251387 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2025-04-23 17:19:22.448856 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2025-04-23 17:19:22.637721 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2025-04-23 17:19:22.831829 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2025-04-23 17:19:23.046317 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2025-04-23 17:19:23.260222 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2025-04-23 17:19:23.466595 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2025-04-23 17:19:23.655459 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2025-04-23 17:19:23.845245 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2025-04-23 17:19:24.04081 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2025-04-23 17:19:24.268465 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2025-04-23 17:19:24.451876 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2025-04-23 17:19:24.641594 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2025-04-23 17:19:24.853892 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2025-04-23 17:19:25.060907 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2025-04-23 17:19:25.279048 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2025-04-23 17:19:25.47661 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2025-04-23 17:19:25.665081 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2025-04-23 17:19:25.841999 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2025-04-23 17:19:26.022991 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2025-04-23 17:19:26.220227 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2025-04-23 17:19:26.40743 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2025-04-23 17:19:26.578289 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2025-04-23 17:19:26.767602 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2025-04-23 17:19:26.949664 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2025-04-23 17:19:27.16009 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2025-04-23 17:19:27.323832 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2025-04-23 17:19:27.503846 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2025-04-23 17:19:27.695735 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2025-04-23 17:19:27.902508 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2025-04-23 17:19:28.08599 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2025-04-23 17:19:28.259374 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2025-04-23 17:19:28.42845 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2025-04-23 17:19:28.5979 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2025-04-23 17:19:28.790996 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2025-04-23 17:19:28.960794 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2025-04-23 17:19:29.142247 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2025-04-23 17:19:29.331225 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2025-04-23 17:19:29.508238 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2025-04-23 17:19:29.711959 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2025-04-23 17:19:29.908652 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2025-04-23 17:19:30.074236 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2025-04-23 17:19:30.252841 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2025-04-23 17:19:30.440153 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2025-04-23 17:19:30.654534 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2025-04-23 17:19:30.837033 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2025-04-23 17:19:31.002877 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2025-04-23 17:19:31.188107 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2025-04-23 17:19:31.346453 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2025-04-23 17:19:31.535079 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2025-04-23 17:19:31.72457 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2025-04-23 17:19:31.915789 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2025-04-23 17:19:32.11189 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2025-04-23 17:19:32.322734 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2025-04-23 17:19:32.50042 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2025-04-23 17:19:32.670292 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2025-04-23 17:19:32.859592 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2025-04-23 17:19:33.032149 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2025-04-23 17:19:33.308946 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2025-04-23 17:19:33.494862 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2025-04-23 17:19:33.686845 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2025-04-23 17:19:33.896983 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2025-04-23 17:19:34.10047 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2025-04-23 17:19:34.328936 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2025-04-23 17:19:34.535362 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2025-04-23 17:19:34.735793 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2025-04-23 17:19:34.924033 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2025-04-23 17:19:35.102506 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2025-04-23 17:19:35.320267 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2025-04-23 17:19:35.524372 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2025-04-23 17:19:35.71324 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2025-04-23 17:19:35.920692 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2025-04-23 17:19:36.135514 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2025-04-23 17:19:36.373194 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2025-04-23 17:19:36.561204 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2025-04-23 17:19:36.765312 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2025-04-23 17:19:36.9659 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2025-04-23 17:19:37.16992 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2025-04-23 17:19:37.375206 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2025-04-23 17:19:37.561949 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2025-04-23 17:19:39.57768 INFO::Plotting data for metadata number 2, antibiotics
## 2025-04-23 17:19:39.579743 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2025-04-23 17:19:39.766114 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2025-04-23 17:19:39.969181 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2025-04-23 17:19:40.168017 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2025-04-23 17:19:40.386849 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2025-04-23 17:19:40.594458 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2025-04-23 17:19:40.793088 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2025-04-23 17:19:41.010054 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2025-04-23 17:19:41.238843 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2025-04-23 17:19:41.446668 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2025-04-23 17:19:41.646585 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2025-04-23 17:19:41.857104 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2025-04-23 17:19:42.068991 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2025-04-23 17:19:42.292535 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2025-04-23 17:19:42.511118 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2025-04-23 17:19:42.719247 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2025-04-23 17:19:42.940142 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2025-04-23 17:19:43.154295 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2025-04-23 17:19:43.389111 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2025-04-23 17:19:43.630404 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2025-04-23 17:19:43.864161 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2025-04-23 17:19:44.086959 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2025-04-23 17:19:44.337374 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2025-04-23 17:19:44.524269 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2025-04-23 17:19:44.716641 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2025-04-23 17:19:44.928511 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2025-04-23 17:19:45.140494 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2025-04-23 17:19:45.357029 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2025-04-23 17:19:45.553013 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2025-04-23 17:19:45.751567 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2025-04-23 17:19:45.983897 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2025-04-23 17:19:46.250062 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2025-04-23 17:19:46.482467 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2025-04-23 17:19:46.706223 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2025-04-23 17:19:46.90744 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2025-04-23 17:19:47.136536 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2025-04-23 17:19:47.366022 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2025-04-23 17:19:47.567983 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2025-04-23 17:19:47.774463 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2025-04-23 17:19:48.001134 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2025-04-23 17:19:48.224461 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2025-04-23 17:19:48.429735 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2025-04-23 17:19:48.606689 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2025-04-23 17:19:48.805009 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2025-04-23 17:19:49.006898 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2025-04-23 17:19:49.2462 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2025-04-23 17:19:49.4642 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2025-04-23 17:19:49.688213 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2025-04-23 17:19:49.918023 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2025-04-23 17:19:50.148792 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2025-04-23 17:19:50.377977 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2025-04-23 17:19:50.589457 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2025-04-23 17:19:50.810716 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2025-04-23 17:19:51.053101 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2025-04-23 17:19:51.283429 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2025-04-23 17:19:51.488239 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2025-04-23 17:19:51.697718 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2025-04-23 17:19:51.913352 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2025-04-23 17:19:52.135821 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2025-04-23 17:19:52.339387 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2025-04-23 17:19:52.529947 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2025-04-23 17:19:52.746042 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2025-04-23 17:19:52.985371 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2025-04-23 17:19:53.189883 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2025-04-23 17:19:53.391927 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2025-04-23 17:19:53.604275 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2025-04-23 17:19:53.827557 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2025-04-23 17:19:54.111827 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2025-04-23 17:19:54.324087 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2025-04-23 17:19:54.51867 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2025-04-23 17:19:54.735913 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2025-04-23 17:19:54.969995 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2025-04-23 17:19:55.176771 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2025-04-23 17:19:55.400522 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2025-04-23 17:19:55.595155 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2025-04-23 17:19:55.810276 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2025-04-23 17:19:56.064437 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2025-04-23 17:19:56.288312 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2025-04-23 17:19:56.501566 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2025-04-23 17:19:56.707354 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2025-04-23 17:19:56.910972 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2025-04-23 17:19:57.138887 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2025-04-23 17:19:57.348721 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2025-04-23 17:19:57.570591 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2025-04-23 17:19:57.800735 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2025-04-23 17:19:58.041793 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2025-04-23 17:19:58.274156 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2025-04-23 17:19:58.512582 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2025-04-23 17:19:58.763641 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2025-04-23 17:19:58.969123 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2025-04-23 17:19:59.209351 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2025-04-23 17:19:59.403797 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2025-04-23 17:19:59.610408 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2025-04-23 17:19:59.807275 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2025-04-23 17:20:00.038307 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2025-04-23 17:20:00.243433 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2025-04-23 17:20:00.430692 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2025-04-23 17:20:00.63478 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2025-04-23 17:20:00.836836 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2025-04-23 17:20:01.078348 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2025-04-23 17:20:01.286607 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2025-04-23 17:20:01.488866 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2025-04-23 17:20:01.705054 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2025-04-23 17:20:01.943146 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2025-04-23 17:20:02.146172 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2025-04-23 17:20:02.334856 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2025-04-23 17:20:02.541583 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2025-04-23 17:20:02.752976 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2025-04-23 17:20:03.000222 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2025-04-23 17:20:03.212284 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2025-04-23 17:20:03.415337 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2025-04-23 17:20:03.624281 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2025-04-23 17:20:03.858432 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2025-04-23 17:20:04.075216 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2025-04-23 17:20:04.291423 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2025-04-23 17:20:04.48089 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2025-04-23 17:20:04.672475 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2025-04-23 17:20:04.931899 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2025-04-23 17:20:05.158552 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2025-04-23 17:20:05.391798 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2025-04-23 17:20:05.621657 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2025-04-23 17:20:05.859453 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2025-04-23 17:20:06.084869 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2025-04-23 17:20:06.302361 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2025-04-23 17:20:06.494685 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2025-04-23 17:20:06.716121 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2025-04-23 17:20:06.953618 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2025-04-23 17:20:07.15439 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2025-04-23 17:20:07.372896 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2025-04-23 17:20:07.565102 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2025-04-23 17:20:07.798953 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2025-04-23 17:20:08.017039 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2025-04-23 17:20:08.241949 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2025-04-23 17:20:08.46372 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2025-04-23 17:20:08.701192 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2025-04-23 17:20:08.967213 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2025-04-23 17:20:09.204441 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2025-04-23 17:20:09.426572 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2025-04-23 17:20:09.643867 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2025-04-23 17:20:09.897934 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2025-04-23 17:20:10.122845 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2025-04-23 17:20:10.351917 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2025-04-23 17:20:10.578144 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2025-04-23 17:20:10.775469 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2025-04-23 17:20:11.024968 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2025-04-23 17:20:11.241943 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2025-04-23 17:20:11.447727 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2025-04-23 17:20:11.663314 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2025-04-23 17:20:11.912158 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2025-04-23 17:20:12.121474 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2025-04-23 17:20:12.326712 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2025-04-23 17:20:12.543887 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2025-04-23 17:20:12.74924 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2025-04-23 17:20:12.973297 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2025-04-23 17:20:13.160779 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2025-04-23 17:20:13.377336 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2025-04-23 17:20:13.590595 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2025-04-23 17:20:13.833986 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2025-04-23 17:20:14.037263 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2025-04-23 17:20:14.248828 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2025-04-23 17:20:14.451454 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2025-04-23 17:20:14.782927 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2025-04-23 17:20:15.02457 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2025-04-23 17:20:15.247151 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2025-04-23 17:20:15.489651 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2025-04-23 17:20:15.725881 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2025-04-23 17:20:15.975097 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2025-04-23 17:20:16.216785 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2025-04-23 17:20:16.462192 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2025-04-23 17:20:16.688098 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2025-04-23 17:20:16.92867 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2025-04-23 17:20:17.153134 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2025-04-23 17:20:17.383603 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2025-04-23 17:20:17.620916 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2025-04-23 17:20:17.847574 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2025-04-23 17:20:18.091751 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2025-04-23 17:20:18.299334 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2025-04-23 17:20:18.517917 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2025-04-23 17:20:18.748476 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2025-04-23 17:20:18.977245 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2025-04-23 17:20:19.209726 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2025-04-23 17:20:19.424663 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2025-04-23 17:20:19.646308 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2025-04-23 17:20:19.86958 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2025-04-23 17:20:20.117006 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2025-04-23 17:20:20.355463 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2025-04-23 17:20:20.553358 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2025-04-23 17:20:20.767287 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2025-04-23 17:20:20.987495 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2025-04-23 17:20:21.203847 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2025-04-23 17:20:21.404657 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2025-04-23 17:20:21.617898 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2025-04-23 17:20:21.834293 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2025-04-23 17:20:22.050083 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2025-04-23 17:20:22.265758 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2025-04-23 17:20:22.439088 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2025-04-23 17:20:22.653973 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2025-04-23 17:20:22.856952 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2025-04-23 17:20:23.097495 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2025-04-23 17:20:23.323717 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2025-04-23 17:20:23.546718 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2025-04-23 17:20:23.779508 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2025-04-23 17:20:24.011613 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2025-04-23 17:20:24.20343 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2025-04-23 17:20:24.411346 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2025-04-23 17:20:24.652362 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2025-04-23 17:20:24.893248 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2025-04-23 17:20:25.169874 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2025-04-23 17:20:25.395112 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2025-04-23 17:20:25.618738 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2025-04-23 17:20:25.828637 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2025-04-23 17:20:26.087477 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2025-04-23 17:20:26.342307 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2025-04-23 17:20:26.582128 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2025-04-23 17:20:26.830309 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2025-04-23 17:20:27.056242 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2025-04-23 17:20:27.307728 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2025-04-23 17:20:27.533197 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2025-04-23 17:20:27.770875 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2025-04-23 17:20:27.989099 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2025-04-23 17:20:28.238865 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2025-04-23 17:20:28.457741 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2025-04-23 17:20:28.687903 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2025-04-23 17:20:28.930542 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2025-04-23 17:20:29.155642 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2025-04-23 17:20:29.39469 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2025-04-23 17:20:29.631078 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2025-04-23 17:20:29.864258 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2025-04-23 17:20:30.103056 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2025-04-23 17:20:30.353382 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2025-04-23 17:20:30.585071 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2025-04-23 17:20:30.806019 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2025-04-23 17:20:31.022012 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2025-04-23 17:20:31.235083 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2025-04-23 17:20:31.464938 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2025-04-23 17:20:31.66833 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2025-04-23 17:20:31.885272 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2025-04-23 17:20:32.109109 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2025-04-23 17:20:32.349453 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2025-04-23 17:20:32.575371 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2025-04-23 17:20:32.817377 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2025-04-23 17:20:33.043586 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2025-04-23 17:20:33.268109 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2025-04-23 17:20:33.513484 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2025-04-23 17:20:33.749966 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2025-04-23 17:20:33.969376 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2025-04-23 17:20:34.204032 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2025-04-23 17:20:34.457438 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2025-04-23 17:20:34.686183 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2025-04-23 17:20:34.933947 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2025-04-23 17:20:35.143759 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2025-04-23 17:20:35.403321 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2025-04-23 17:20:35.629953 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2025-04-23 17:20:35.874945 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2025-04-23 17:20:36.124539 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2025-04-23 17:20:36.393326 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2025-04-23 17:20:36.708884 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2025-04-23 17:20:36.94857 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2025-04-23 17:20:37.190669 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2025-04-23 17:20:37.438848 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2025-04-23 17:20:37.70573 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2025-04-23 17:20:37.969782 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2025-04-23 17:20:38.201264 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2025-04-23 17:20:38.432384 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2025-04-23 17:20:38.664702 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2025-04-23 17:20:38.932227 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2025-04-23 17:20:39.160595 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2025-04-23 17:20:39.391567 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2025-04-23 17:20:39.635085 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2025-04-23 17:20:39.889511 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2025-04-23 17:20:40.170737 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2025-04-23 17:20:40.402737 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2025-04-23 17:20:40.638392 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2025-04-23 17:20:40.881794 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2025-04-23 17:20:41.14794 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2025-04-23 17:20:41.390086 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2025-04-23 17:20:41.618494 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2025-04-23 17:20:41.861426 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2025-04-23 17:20:42.091368 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2025-04-23 17:20:42.345241 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2025-04-23 17:20:42.589484 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2025-04-23 17:20:42.844884 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2025-04-23 17:20:43.092975 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2025-04-23 17:20:43.358894 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2025-04-23 17:20:43.601328 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2025-04-23 17:20:43.862416 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2025-04-23 17:20:44.140941 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2025-04-23 17:20:44.39036 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2025-04-23 17:20:44.677566 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2025-04-23 17:20:44.919064 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2025-04-23 17:20:45.163817 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2025-04-23 17:20:45.41399 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2025-04-23 17:20:45.660296 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2025-04-23 17:20:45.900947 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2025-04-23 17:20:46.142245 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2025-04-23 17:20:46.38078 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2025-04-23 17:20:46.604509 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2025-04-23 17:20:46.88678 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2025-04-23 17:20:47.131131 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2025-04-23 17:20:47.367185 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2025-04-23 17:20:47.60152 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2025-04-23 17:20:47.861488 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2025-04-23 17:20:48.107351 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2025-04-23 17:20:48.349904 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2025-04-23 17:20:48.580676 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2025-04-23 17:20:48.796977 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2025-04-23 17:20:49.061952 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2025-04-23 17:20:49.290803 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2025-04-23 17:20:49.518252 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2025-04-23 17:20:49.741697 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2025-04-23 17:20:49.990926 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2025-04-23 17:20:50.219657 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2025-04-23 17:20:50.449004 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2025-04-23 17:20:50.686424 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2025-04-23 17:20:50.907697 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2025-04-23 17:20:51.177621 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2025-04-23 17:20:51.423612 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2025-04-23 17:20:51.642247 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2025-04-23 17:20:51.86005 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2025-04-23 17:20:52.115612 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2025-04-23 17:20:52.345766 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2025-04-23 17:20:52.676653 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2025-04-23 17:20:52.90413 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2025-04-23 17:20:53.118332 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2025-04-23 17:20:53.369659 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2025-04-23 17:20:53.605628 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2025-04-23 17:20:53.821731 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2025-04-23 17:20:54.034655 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2025-04-23 17:20:54.275174 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2025-04-23 17:20:54.507606 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2025-04-23 17:20:54.738071 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2025-04-23 17:20:54.961182 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2025-04-23 17:20:55.18732 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2025-04-23 17:20:55.460562 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2025-04-23 17:20:55.710564 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2025-04-23 17:20:55.959911 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2025-04-23 17:20:56.205623 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2025-04-23 17:20:56.467714 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2025-04-23 17:20:56.716958 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2025-04-23 17:20:56.965229 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2025-04-23 17:20:57.196083 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2025-04-23 17:20:57.455934 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2025-04-23 17:20:57.714918 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2025-04-23 17:20:57.971563 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2025-04-23 17:20:58.219076 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2025-04-23 17:20:58.434948 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2025-04-23 17:20:58.684971 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2025-04-23 17:20:58.917862 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2025-04-23 17:20:59.154903 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2025-04-23 17:20:59.363104 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2025-04-23 17:21:00.318879 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2025-04-23 17:21:00.516924 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2025-04-23 17:21:00.726089 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2025-04-23 17:21:00.922547 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2025-04-23 17:21:01.132235 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2025-04-23 17:21:01.363455 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2025-04-23 17:21:01.588164 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2025-04-23 17:21:01.820842 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2025-04-23 17:21:02.075638 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2025-04-23 17:21:02.295013 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2025-04-23 17:21:02.501228 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2025-04-23 17:21:02.725514 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2025-04-23 17:21:02.921588 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2025-04-23 17:21:03.123655 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2025-04-23 17:21:03.324061 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2025-04-23 17:21:03.542366 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2025-04-23 17:21:03.7457 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2025-04-23 17:21:03.940696 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2025-04-23 17:21:04.14951 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2025-04-23 17:21:04.343601 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2025-04-23 17:21:04.533609 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2025-04-23 17:21:04.730948 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2025-04-23 17:21:04.974037 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2025-04-23 17:21:05.231849 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2025-04-23 17:21:05.473676 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2025-04-23 17:21:05.704181 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2025-04-23 17:21:05.903085 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2025-04-23 17:21:06.102704 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2025-04-23 17:21:06.300872 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2025-04-23 17:21:06.502349 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2025-04-23 17:21:06.713645 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2025-04-23 17:21:06.911332 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2025-04-23 17:21:07.124418 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2025-04-23 17:21:07.342811 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2025-04-23 17:21:07.558878 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2025-04-23 17:21:07.777757 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2025-04-23 17:21:08.00278 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2025-04-23 17:21:08.214954 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2025-04-23 17:21:08.399822 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2025-04-23 17:21:08.598035 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2025-04-23 17:21:08.801654 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2025-04-23 17:21:08.990122 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2025-04-23 17:21:09.194914 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2025-04-23 17:21:09.391737 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2025-04-23 17:21:09.590949 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2025-04-23 17:21:09.778742 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2025-04-23 17:21:09.959278 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2025-04-23 17:21:10.166402 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2025-04-23 17:21:10.374652 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2025-04-23 17:21:10.559644 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2025-04-23 17:21:10.767527 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2025-04-23 17:21:10.965286 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2025-04-23 17:21:11.153346 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2025-04-23 17:21:11.349833 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2025-04-23 17:21:11.560599 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2025-04-23 17:21:11.765167 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2025-04-23 17:21:11.981436 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2025-04-23 17:21:12.170258 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2025-04-23 17:21:12.373975 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2025-04-23 17:21:12.569129 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2025-04-23 17:21:12.780994 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2025-04-23 17:21:12.968842 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2025-04-23 17:21:13.150619 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2025-04-23 17:21:13.340564 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2025-04-23 17:21:13.553644 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2025-04-23 17:21:13.779533 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2025-04-23 17:21:14.00688 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2025-04-23 17:21:14.201895 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2025-04-23 17:21:14.412021 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2025-04-23 17:21:14.636158 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2025-04-23 17:21:14.839335 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2025-04-23 17:21:15.032162 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2025-04-23 17:21:15.22256 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2025-04-23 17:21:15.423417 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2025-04-23 17:21:15.637819 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2025-04-23 17:21:15.857594 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2025-04-23 17:21:16.063547 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2025-04-23 17:21:16.282162 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2025-04-23 17:21:16.514187 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2025-04-23 17:21:16.721815 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2025-04-23 17:21:16.9338 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2025-04-23 17:21:17.151507 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2025-04-23 17:21:17.383686 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2025-04-23 17:21:17.635901 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2025-04-23 17:21:17.839014 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2025-04-23 17:21:18.052818 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2025-04-23 17:21:18.292544 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2025-04-23 17:21:20.561413 INFO::Plotting data for metadata number 3, age
## 2025-04-23 17:21:20.563416 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:20.894691 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:21.169505 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:21.408105 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:21.658779 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:21.877862 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:22.096956 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:22.316848 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:22.550438 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:22.76248 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:22.946422 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:23.163885 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:23.382832 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:23.598225 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:23.789104 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:24.011163 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:24.237575 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:24.488991 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:24.711703 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:24.937096 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:25.159331 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:25.394342 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:25.652099 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:25.853398 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:26.079425 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:26.334148 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:26.575925 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:26.811055 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:27.032041 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:27.281852 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:27.476255 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:27.678512 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:27.921841 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:28.135492 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:28.365746 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:28.569148 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:28.792357 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:29.020407 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:29.27913 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:29.477992 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:29.693043 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:29.911042 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:30.151496 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:30.370949 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:30.590628 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:30.816082 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:31.056503 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:31.252051 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:31.451861 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:31.657865 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:31.884473 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:32.080407 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:32.285549 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:32.512959 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:32.717835 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:32.923838 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:33.114907 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:33.327622 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:33.564276 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:33.761088 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:33.961794 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:34.171151 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:34.39033 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:34.55604 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:34.744582 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:34.943156 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:35.178987 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:35.368786 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:35.55575 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:35.773161 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:36.00794 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:36.191001 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:36.404917 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:36.612933 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:36.857006 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:37.061848 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:37.275839 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:37.499143 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:37.738932 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:37.926749 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:38.137633 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:38.342411 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:38.599782 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:38.834787 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:39.058187 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:39.267465 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:39.616489 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:39.865105 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:40.077256 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:40.286302 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:40.527669 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:40.785251 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:40.987268 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:41.2192 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:41.456771 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:41.682792 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:41.902444 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:42.131375 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:42.347491 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:42.594729 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:42.795231 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:43.028301 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:43.253945 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:43.46542 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:43.674819 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:43.862648 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:44.060468 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:44.285041 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:44.48444 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:44.695786 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:44.89313 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:45.114743 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:45.322706 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:45.520134 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:45.720383 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:45.915623 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:46.123141 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:46.312548 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:46.531739 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:46.737169 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:46.965273 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:47.167293 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:47.369901 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:47.578827 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:47.811858 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:48.0124 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:48.188698 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:48.366244 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:48.565194 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:48.782677 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:49.001976 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:49.206321 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:49.44672 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:49.664637 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:49.87707 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:50.083064 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:50.332043 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:50.575513 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:50.781823 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:51.005057 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:51.27915 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:51.49028 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:51.735195 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:51.965724 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:52.225516 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:52.47078 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:52.675411 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:52.904487 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:53.147541 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:53.381751 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:53.622651 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:53.863985 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:54.128448 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:54.355078 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:54.591438 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:54.826556 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:55.099708 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:55.347915 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:55.601746 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:55.845903 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:56.143419 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-23 17:21:56.40488 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:56.659626 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-23 17:21:56.92884 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
##
## Calculating mean abundance in: IBD
##
## Calculating mean abundance in: Control
##
## Calculating effect size in: IBD
##
## Initiating prioritization
##
## Calculating meta-rank and prioritizing metabolic features
## 2025-04-23 17:21:59.595296 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2025-04-23 17:21:59.60614 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2025-04-23 17:21:59.628371 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv
abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames
taxonomy_df = read.csv(file = mets_taxonomy)
# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df)
The Macarron::Macarron()
function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:
# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df)
# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)
# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]
# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
mod.assn = prism_modules)
# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules)
# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
mac.qval = prism_qval)
# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
mod.assn = prism_modules,
mac.ava = prism_ava,
mac.qval = prism_qval,
mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]
# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)
Session info from running the demo in R can be displayed with the following command.
sessionInfo()
## R version 4.5.0 Patched (2025-04-21 r88169)
## Platform: x86_64-apple-darwin20
## Running under: macOS Monterey 12.7.6
##
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/4.5-x86_64/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/4.5-x86_64/Resources/lib/libRlapack.dylib; LAPACK version 3.12.1
##
## locale:
## [1] C/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] Macarron_1.13.0 SummarizedExperiment_1.39.0
## [3] Biobase_2.69.0 GenomicRanges_1.61.0
## [5] GenomeInfoDb_1.45.0 IRanges_2.43.0
## [7] S4Vectors_0.47.0 BiocGenerics_0.55.0
## [9] generics_0.1.3 MatrixGenerics_1.21.0
## [11] matrixStats_1.5.0 BiocStyle_2.37.0
##
## loaded via a namespace (and not attached):
## [1] mnormt_2.1.1 DBI_1.2.3 pbapply_1.7-2
## [4] gridExtra_2.3 rlang_1.1.6 magrittr_2.0.3
## [7] compiler_4.5.0 RSQLite_2.3.9 mgcv_1.9-3
## [10] png_0.1-8 vctrs_0.6.5 stringr_1.5.1
## [13] pkgconfig_2.0.3 crayon_1.5.3 fastmap_1.2.0
## [16] backports_1.5.0 XVector_0.49.0 labeling_0.4.3
## [19] rmarkdown_2.29 UCSC.utils_1.5.0 preprocessCore_1.71.0
## [22] bit_4.6.0 xfun_0.52 cachem_1.1.0
## [25] jsonlite_2.0.0 blob_1.2.4 DelayedArray_0.35.1
## [28] BiocParallel_1.43.0 psych_2.5.3 Maaslin2_1.23.0
## [31] parallel_4.5.0 cluster_2.1.8.1 biglm_0.9-3
## [34] R6_2.6.1 RColorBrewer_1.1-3 bslib_0.9.0
## [37] stringi_1.8.7 rpart_4.1.24 jquerylib_0.1.4
## [40] Rcpp_1.0.14 bookdown_0.43 iterators_1.0.14
## [43] knitr_1.50 WGCNA_1.73 base64enc_0.1-3
## [46] Matrix_1.7-3 splines_4.5.0 nnet_7.3-20
## [49] tidyselect_1.2.1 rstudioapi_0.17.1 abind_1.4-8
## [52] yaml_2.3.10 doParallel_1.0.17 codetools_0.2-20
## [55] plyr_1.8.9 lattice_0.22-7 tibble_3.2.1
## [58] withr_3.0.2 KEGGREST_1.49.0 evaluate_1.0.3
## [61] foreign_0.8-90 survival_3.8-3 getopt_1.20.4
## [64] Biostrings_2.77.0 pillar_1.10.2 BiocManager_1.30.25
## [67] checkmate_2.3.2 foreach_1.5.2 pcaPP_2.0-5
## [70] ggplot2_3.5.2 munsell_0.5.1 scales_1.3.0
## [73] glue_1.8.0 Hmisc_5.2-3 tools_4.5.0
## [76] robustbase_0.99-4-1 data.table_1.17.0 mvtnorm_1.3-3
## [79] fastcluster_1.2.6 grid_4.5.0 optparse_1.7.5
## [82] impute_1.83.0 AnnotationDbi_1.71.0 colorspace_2.1-1
## [85] nlme_3.1-168 GenomeInfoDbData_1.2.14 htmlTable_2.4.3
## [88] Formula_1.2-5 cli_3.6.5 S4Arrays_1.9.0
## [91] dplyr_1.1.4 DEoptimR_1.1-3-1 gtable_0.3.6
## [94] hash_2.2.6.3 logging_0.10-108 dynamicTreeCut_1.63-1
## [97] sass_0.4.10 digest_0.6.37 SparseArray_1.9.0
## [100] farver_2.1.2 htmlwidgets_1.6.4 memoise_2.0.1
## [103] htmltools_0.5.8.1 lifecycle_1.0.4 httr_1.4.7
## [106] GO.db_3.21.0 bit64_4.6.0-1
The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID()
. This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.
taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)
A record of all chosen parameters and steps that were followed during execution.
This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size
) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:
This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.
Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence
argument.
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df,
min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
min_prevalence = 0.5)
By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size
) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA
and dynamicTreeCut
.
# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)
# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df,
min_module_size = 10)
Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable
argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories.
Defaults can be changed with the arguments fixed_effects
, random_effects
and reference
. In the demo example, fixed effects
and reference
can be defined as follows:
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules,
metadata_variable = "diagnosis",
fixed_effects = c("diagnosis","age","antibiotics"),
reference = c("diagnosis,Control";"antibiotics,No"))
The package source contains a script MacarronCMD.R
in inst/scripts
to invoke Macarron in the command line using Rscript.
The inst/scripts
folder also contains a README file that comprehensively documents the usage of the script.