mist
This is the released version of mist; for the devel version, see mist.
All Bioconductor versions of mist
3.24 (devel), 3.23 (release), 3.22, 3.21
Differential Methylation Analysis for scDNAm Data
Bioconductor version: 3.23 · Package version: 1.4.0
mist (Methylation Inference for Single-cell along Trajectory) is a hierarchical Bayesian framework for modeling DNA methylation trajectories and performing differential methylation (DM) analysis in single-cell DNA methylation (scDNAm) data. It estimates developmental-stage-specific variations, identifies genomic features with drastic changes along pseudotime, and, for two phenotypic groups, detects features with distinct temporal methylation patterns. mist uses Gibbs sampling to estimate parameters for temporal changes and stage-specific variations.
Maintainer: Daoyu Duan <dxd429 at case.edu>
Citation
From within R, enter citation("mist"):
Daoyu Duan. mist: Differential Methylation Analysis for scDNAm Data. doi:10.18129/B9.bioc.mist, R package version 1.4.0, https://bioconductor.org/packages/mist.
Generated from the package metadata; it may differ from the package's own citation.
Installation
To install this package, start R (version "4.6") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("mist")For older versions of R, please refer to the appropriate Bioconductor release.
Details
| Version | 1.4.0 |
| License | MIT + file LICENSE |
| URL | https://https://github.com/dxd429/mist |
| Bug Reports | https://https://github.com/dxd429/mist/issues |
| Last updated | 2026-04-28 |
| In Bioconductor since | BioC 3.21 (R-4.5) (1 year) |
| Downloads rank | 2188 of 2,418 |
| Source branch | RELEASE_3_23 |
| Build report | Bioconductor build system, r-universe |
| biocViews | DNAMethylation, DifferentialMethylation, Epigenetics, SingleCell, Software |
| Package Short Url | https://bioconductor.org/packages/mist/ |
Documentation
To view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("mist")| mist:methylation inference for single-cell along trajectory | HTML | R Script |
| Reference Manual | ||
| NEWS | Text |
Download
Follow the installation instructions to use this package in your R session.
| Source package | mist_1.4.0.tar.gz |
| Windows binary (x86_64) | mist_1.4.0.zip |
| macOS binary (arm64) | mist_1.4.0.tgz |
| macOS binary (x86_64) | mist_1.4.0.tgz |
| Source Repository | git clone https://git.bioconductor.org/packages/mist |
| Source Repository (Developer Access) | git clone git@git.bioconductor.org:packages/mist |
| Package Downloads Report | Download Stats |
Dependencies
Depends: R (>= 4.5.0)
Imports: BiocParallel, MCMCpack, Matrix, S4Vectors, methods, rtracklayer, car, mvtnorm, SummarizedExperiment, SingleCellExperiment, BiocGenerics, stats, rlang