Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.
If you have questions, please direct it to: Macarron Forum
Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:
if(!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("Macarron")
Macarron can be run from the command line or as an R function. Both methods require the same
arguments, have the same options, and use the same default settings. The package includes the
wrapper Macarron()
as well as functions which perform different steps in the Macarron
framework.
Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.
If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID
(see Advanced Topics).
By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv
. Another file, prioritized_metabolites_characterizable.csv
is a subset of prioritized_metabolites_all.csv
and only contains metabolic features which covary with at least one annotated metabolite.
The columns in these output files are:
Maaslin2
.Example (demo) input files can be found under inst/extdata
folder of the Macarron
source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv
, demo_annotations.csv
, demo_metadata.csv
, and demo_taxonomy.csv
.
library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
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## Welcome to Bioconductor
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prism_abundances <- system.file(
'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
input_annotations = prism_annotations,
input_metadata = prism_metadata,
input_taxonomy = mets_taxonomy)
## 2025-04-15 21:39:46.420463 INFO::Creating output folder.
## 2025-04-15 21:39:46.442178 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2025-04-15 21:39:46.535318 INFO::Summarized Experiment created.
## 2025-04-15 21:39:46.538623 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
##
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2025-04-15 21:39:52.867544 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2025-04-15 21:39:52.871215 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## 2025-04-15 21:39:56.022674 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2025-04-15 21:39:58.529445 INFO::Writing function arguments to log file
## 2025-04-15 21:39:58.546809 INFO::Verifying options selected are valid
## 2025-04-15 21:39:58.597188 INFO::Determining format of input files
## 2025-04-15 21:39:58.599093 INFO::Input format is data samples as columns and metadata samples as rows
## 2025-04-15 21:39:58.617653 INFO::Formula for fixed effects: expr ~ diagnosis + age + antibiotics
## 2025-04-15 21:39:58.620067 INFO::Filter data based on min abundance and min prevalence
## 2025-04-15 21:39:58.621517 INFO::Total samples in data: 102
## 2025-04-15 21:39:58.622895 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2025-04-15 21:39:58.634807 INFO::Total filtered features: 0
## 2025-04-15 21:39:58.636636 INFO::Filtered feature names from abundance and prevalence filtering:
## 2025-04-15 21:39:58.654647 INFO::Total filtered features with variance filtering: 0
## 2025-04-15 21:39:58.656621 INFO::Filtered feature names from variance filtering:
## 2025-04-15 21:39:58.658174 INFO::Running selected normalization method: NONE
## 2025-04-15 21:39:58.659686 INFO::Applying z-score to standardize continuous metadata
## 2025-04-15 21:39:58.683806 INFO::Running selected transform method: NONE
## 2025-04-15 21:39:58.68571 INFO::Running selected analysis method: LM
## 2025-04-15 21:39:58.694484 INFO::Fitting model to feature number 1, F1
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## 2025-04-15 21:39:59.592423 INFO::Fitting model to feature number 182, F188
## 2025-04-15 21:39:59.597397 INFO::Fitting model to feature number 183, F189
## 2025-04-15 21:39:59.602211 INFO::Fitting model to feature number 184, F190
## 2025-04-15 21:39:59.607883 INFO::Fitting model to feature number 185, F191
## 2025-04-15 21:39:59.61271 INFO::Fitting model to feature number 186, F192
## 2025-04-15 21:39:59.617422 INFO::Fitting model to feature number 187, F193
## 2025-04-15 21:39:59.622684 INFO::Fitting model to feature number 188, F194
## 2025-04-15 21:39:59.627396 INFO::Fitting model to feature number 189, F195
## 2025-04-15 21:39:59.632154 INFO::Fitting model to feature number 190, F196
## 2025-04-15 21:39:59.636853 INFO::Fitting model to feature number 191, F197
## 2025-04-15 21:39:59.641897 INFO::Fitting model to feature number 192, F198
## 2025-04-15 21:39:59.646613 INFO::Fitting model to feature number 193, F199
## 2025-04-15 21:39:59.651424 INFO::Fitting model to feature number 194, F200
## 2025-04-15 21:39:59.656146 INFO::Fitting model to feature number 195, F201
## 2025-04-15 21:39:59.6609 INFO::Fitting model to feature number 196, F202
## 2025-04-15 21:39:59.665526 INFO::Fitting model to feature number 197, F203
## 2025-04-15 21:39:59.670166 INFO::Fitting model to feature number 198, F204
## 2025-04-15 21:39:59.674771 INFO::Fitting model to feature number 199, F206
## 2025-04-15 21:39:59.679389 INFO::Fitting model to feature number 200, F207
## 2025-04-15 21:39:59.683977 INFO::Fitting model to feature number 201, F208
## 2025-04-15 21:39:59.688579 INFO::Fitting model to feature number 202, F209
## 2025-04-15 21:39:59.693186 INFO::Fitting model to feature number 203, F210
## 2025-04-15 21:39:59.697796 INFO::Fitting model to feature number 204, F211
## 2025-04-15 21:39:59.702317 INFO::Fitting model to feature number 205, F212
## 2025-04-15 21:39:59.706865 INFO::Fitting model to feature number 206, F213
## 2025-04-15 21:39:59.711435 INFO::Fitting model to feature number 207, F214
## 2025-04-15 21:39:59.715971 INFO::Fitting model to feature number 208, F215
## 2025-04-15 21:39:59.720519 INFO::Fitting model to feature number 209, F216
## 2025-04-15 21:39:59.725091 INFO::Fitting model to feature number 210, F217
## 2025-04-15 21:39:59.729631 INFO::Fitting model to feature number 211, F218
## 2025-04-15 21:39:59.734074 INFO::Fitting model to feature number 212, F219
## 2025-04-15 21:39:59.738522 INFO::Fitting model to feature number 213, F220
## 2025-04-15 21:39:59.742987 INFO::Fitting model to feature number 214, F221
## 2025-04-15 21:39:59.74748 INFO::Fitting model to feature number 215, F222
## 2025-04-15 21:39:59.751902 INFO::Fitting model to feature number 216, F223
## 2025-04-15 21:39:59.756357 INFO::Fitting model to feature number 217, F224
## 2025-04-15 21:39:59.760881 INFO::Fitting model to feature number 218, F225
## 2025-04-15 21:39:59.765408 INFO::Fitting model to feature number 219, F226
## 2025-04-15 21:39:59.770049 INFO::Fitting model to feature number 220, F227
## 2025-04-15 21:39:59.802248 INFO::Fitting model to feature number 221, F228
## 2025-04-15 21:39:59.806805 INFO::Fitting model to feature number 222, F229
## 2025-04-15 21:39:59.811402 INFO::Fitting model to feature number 223, F230
## 2025-04-15 21:39:59.815934 INFO::Fitting model to feature number 224, F231
## 2025-04-15 21:39:59.820576 INFO::Fitting model to feature number 225, F232
## 2025-04-15 21:39:59.825175 INFO::Fitting model to feature number 226, F233
## 2025-04-15 21:39:59.829731 INFO::Fitting model to feature number 227, F234
## 2025-04-15 21:39:59.834347 INFO::Fitting model to feature number 228, F235
## 2025-04-15 21:39:59.839053 INFO::Fitting model to feature number 229, F236
## 2025-04-15 21:39:59.843455 INFO::Fitting model to feature number 230, F237
## 2025-04-15 21:39:59.847875 INFO::Fitting model to feature number 231, F238
## 2025-04-15 21:39:59.852214 INFO::Fitting model to feature number 232, F239
## 2025-04-15 21:39:59.856503 INFO::Fitting model to feature number 233, F240
## 2025-04-15 21:39:59.860757 INFO::Fitting model to feature number 234, F241
## 2025-04-15 21:39:59.866999 INFO::Fitting model to feature number 235, F242
## 2025-04-15 21:39:59.874445 INFO::Fitting model to feature number 236, F243
## 2025-04-15 21:39:59.879684 INFO::Fitting model to feature number 237, F244
## 2025-04-15 21:39:59.884082 INFO::Fitting model to feature number 238, F245
## 2025-04-15 21:39:59.888425 INFO::Fitting model to feature number 239, F246
## 2025-04-15 21:39:59.8928 INFO::Fitting model to feature number 240, F247
## 2025-04-15 21:39:59.89713 INFO::Fitting model to feature number 241, F248
## 2025-04-15 21:39:59.901487 INFO::Fitting model to feature number 242, F249
## 2025-04-15 21:39:59.905828 INFO::Fitting model to feature number 243, F250
## 2025-04-15 21:39:59.910215 INFO::Fitting model to feature number 244, F252
## 2025-04-15 21:39:59.914475 INFO::Fitting model to feature number 245, F253
## 2025-04-15 21:39:59.918699 INFO::Fitting model to feature number 246, F254
## 2025-04-15 21:39:59.922872 INFO::Fitting model to feature number 247, F255
## 2025-04-15 21:39:59.927023 INFO::Fitting model to feature number 248, F256
## 2025-04-15 21:39:59.931188 INFO::Fitting model to feature number 249, F257
## 2025-04-15 21:39:59.935483 INFO::Fitting model to feature number 250, F259
## 2025-04-15 21:39:59.939708 INFO::Fitting model to feature number 251, F260
## 2025-04-15 21:39:59.944009 INFO::Fitting model to feature number 252, F261
## 2025-04-15 21:39:59.94825 INFO::Fitting model to feature number 253, F262
## 2025-04-15 21:39:59.952411 INFO::Fitting model to feature number 254, F263
## 2025-04-15 21:39:59.956543 INFO::Fitting model to feature number 255, F264
## 2025-04-15 21:39:59.961583 INFO::Fitting model to feature number 256, F265
## 2025-04-15 21:39:59.968699 INFO::Fitting model to feature number 257, F266
## 2025-04-15 21:39:59.975861 INFO::Fitting model to feature number 258, F267
## 2025-04-15 21:39:59.983121 INFO::Fitting model to feature number 259, F269
## 2025-04-15 21:39:59.990388 INFO::Fitting model to feature number 260, F270
## 2025-04-15 21:39:59.996754 INFO::Fitting model to feature number 261, F271
## 2025-04-15 21:40:00.00117 INFO::Fitting model to feature number 262, F272
## 2025-04-15 21:40:00.005624 INFO::Fitting model to feature number 263, F273
## 2025-04-15 21:40:00.010165 INFO::Fitting model to feature number 264, F274
## 2025-04-15 21:40:00.053499 INFO::Fitting model to feature number 265, F276
## 2025-04-15 21:40:00.060743 INFO::Fitting model to feature number 266, F277
## 2025-04-15 21:40:00.067668 INFO::Fitting model to feature number 267, F278
## 2025-04-15 21:40:00.074562 INFO::Fitting model to feature number 268, F279
## 2025-04-15 21:40:00.081538 INFO::Fitting model to feature number 269, F280
## 2025-04-15 21:40:00.088372 INFO::Fitting model to feature number 270, F281
## 2025-04-15 21:40:00.095354 INFO::Fitting model to feature number 271, F282
## 2025-04-15 21:40:00.102196 INFO::Fitting model to feature number 272, F283
## 2025-04-15 21:40:00.108976 INFO::Fitting model to feature number 273, F284
## 2025-04-15 21:40:00.11575 INFO::Fitting model to feature number 274, F285
## 2025-04-15 21:40:00.122749 INFO::Fitting model to feature number 275, F286
## 2025-04-15 21:40:00.129655 INFO::Fitting model to feature number 276, F287
## 2025-04-15 21:40:00.136569 INFO::Fitting model to feature number 277, F288
## 2025-04-15 21:40:00.143494 INFO::Fitting model to feature number 278, F289
## 2025-04-15 21:40:00.150402 INFO::Fitting model to feature number 279, F290
## 2025-04-15 21:40:00.157308 INFO::Fitting model to feature number 280, F292
## 2025-04-15 21:40:00.164228 INFO::Fitting model to feature number 281, F293
## 2025-04-15 21:40:00.171517 INFO::Fitting model to feature number 282, F294
## 2025-04-15 21:40:00.178386 INFO::Fitting model to feature number 283, F295
## 2025-04-15 21:40:00.185287 INFO::Fitting model to feature number 284, F296
## 2025-04-15 21:40:00.192256 INFO::Fitting model to feature number 285, F297
## 2025-04-15 21:40:00.199225 INFO::Fitting model to feature number 286, F298
## 2025-04-15 21:40:00.206201 INFO::Fitting model to feature number 287, F299
## 2025-04-15 21:40:00.213046 INFO::Fitting model to feature number 288, F300
## 2025-04-15 21:40:00.21991 INFO::Fitting model to feature number 289, F301
## 2025-04-15 21:40:00.226749 INFO::Fitting model to feature number 290, F302
## 2025-04-15 21:40:00.233653 INFO::Fitting model to feature number 291, F303
## 2025-04-15 21:40:00.240787 INFO::Fitting model to feature number 292, F304
## 2025-04-15 21:40:00.247716 INFO::Fitting model to feature number 293, F305
## 2025-04-15 21:40:00.254806 INFO::Fitting model to feature number 294, F306
## 2025-04-15 21:40:00.261974 INFO::Fitting model to feature number 295, F307
## 2025-04-15 21:40:00.269129 INFO::Fitting model to feature number 296, F308
## 2025-04-15 21:40:00.274984 INFO::Fitting model to feature number 297, F309
## 2025-04-15 21:40:00.280014 INFO::Fitting model to feature number 298, F310
## 2025-04-15 21:40:00.285034 INFO::Fitting model to feature number 299, F311
## 2025-04-15 21:40:00.289479 INFO::Fitting model to feature number 300, F312
## 2025-04-15 21:40:00.294079 INFO::Fitting model to feature number 301, F313
## 2025-04-15 21:40:00.298581 INFO::Fitting model to feature number 302, F315
## 2025-04-15 21:40:00.303134 INFO::Fitting model to feature number 303, F316
## 2025-04-15 21:40:00.307623 INFO::Fitting model to feature number 304, F317
## 2025-04-15 21:40:00.311955 INFO::Fitting model to feature number 305, F318
## 2025-04-15 21:40:00.316322 INFO::Fitting model to feature number 306, F319
## 2025-04-15 21:40:00.320606 INFO::Fitting model to feature number 307, F320
## 2025-04-15 21:40:00.324987 INFO::Fitting model to feature number 308, F321
## 2025-04-15 21:40:00.329367 INFO::Fitting model to feature number 309, F322
## 2025-04-15 21:40:00.33376 INFO::Fitting model to feature number 310, F323
## 2025-04-15 21:40:00.338049 INFO::Fitting model to feature number 311, F324
## 2025-04-15 21:40:00.342382 INFO::Fitting model to feature number 312, F325
## 2025-04-15 21:40:00.346618 INFO::Fitting model to feature number 313, F326
## 2025-04-15 21:40:00.350975 INFO::Fitting model to feature number 314, F327
## 2025-04-15 21:40:00.355276 INFO::Fitting model to feature number 315, F328
## 2025-04-15 21:40:00.359551 INFO::Fitting model to feature number 316, F329
## 2025-04-15 21:40:00.363832 INFO::Fitting model to feature number 317, F330
## 2025-04-15 21:40:00.368205 INFO::Fitting model to feature number 318, F331
## 2025-04-15 21:40:00.37322 INFO::Fitting model to feature number 319, F332
## 2025-04-15 21:40:00.378294 INFO::Fitting model to feature number 320, F333
## 2025-04-15 21:40:00.383186 INFO::Fitting model to feature number 321, F334
## 2025-04-15 21:40:00.387869 INFO::Fitting model to feature number 322, F335
## 2025-04-15 21:40:00.392746 INFO::Fitting model to feature number 323, F336
## 2025-04-15 21:40:00.39726 INFO::Fitting model to feature number 324, F337
## 2025-04-15 21:40:00.401793 INFO::Fitting model to feature number 325, F338
## 2025-04-15 21:40:00.406292 INFO::Fitting model to feature number 326, F339
## 2025-04-15 21:40:00.410664 INFO::Fitting model to feature number 327, F340
## 2025-04-15 21:40:00.415268 INFO::Fitting model to feature number 328, F342
## 2025-04-15 21:40:00.419633 INFO::Fitting model to feature number 329, F343
## 2025-04-15 21:40:00.42395 INFO::Fitting model to feature number 330, F344
## 2025-04-15 21:40:00.428241 INFO::Fitting model to feature number 331, F345
## 2025-04-15 21:40:00.432555 INFO::Fitting model to feature number 332, F346
## 2025-04-15 21:40:00.436799 INFO::Fitting model to feature number 333, F347
## 2025-04-15 21:40:00.441042 INFO::Fitting model to feature number 334, F348
## 2025-04-15 21:40:00.445329 INFO::Fitting model to feature number 335, F350
## 2025-04-15 21:40:00.449592 INFO::Fitting model to feature number 336, F351
## 2025-04-15 21:40:00.453864 INFO::Fitting model to feature number 337, F352
## 2025-04-15 21:40:00.458139 INFO::Fitting model to feature number 338, F353
## 2025-04-15 21:40:00.462392 INFO::Fitting model to feature number 339, F355
## 2025-04-15 21:40:00.466611 INFO::Fitting model to feature number 340, F356
## 2025-04-15 21:40:00.470828 INFO::Fitting model to feature number 341, F357
## 2025-04-15 21:40:00.475156 INFO::Fitting model to feature number 342, F358
## 2025-04-15 21:40:00.479522 INFO::Fitting model to feature number 343, F359
## 2025-04-15 21:40:00.483779 INFO::Fitting model to feature number 344, F360
## 2025-04-15 21:40:00.488036 INFO::Fitting model to feature number 345, F361
## 2025-04-15 21:40:00.492389 INFO::Fitting model to feature number 346, F362
## 2025-04-15 21:40:00.496701 INFO::Fitting model to feature number 347, F363
## 2025-04-15 21:40:00.50145 INFO::Fitting model to feature number 348, F364
## 2025-04-15 21:40:00.50738 INFO::Fitting model to feature number 349, F365
## 2025-04-15 21:40:00.513859 INFO::Fitting model to feature number 350, F366
## 2025-04-15 21:40:00.521299 INFO::Fitting model to feature number 351, F367
## 2025-04-15 21:40:00.528849 INFO::Fitting model to feature number 352, F368
## 2025-04-15 21:40:00.534803 INFO::Fitting model to feature number 353, F369
## 2025-04-15 21:40:00.539307 INFO::Fitting model to feature number 354, F370
## 2025-04-15 21:40:00.543666 INFO::Fitting model to feature number 355, F371
## 2025-04-15 21:40:00.548068 INFO::Fitting model to feature number 356, F372
## 2025-04-15 21:40:00.552398 INFO::Fitting model to feature number 357, F373
## 2025-04-15 21:40:00.556792 INFO::Fitting model to feature number 358, F374
## 2025-04-15 21:40:00.561217 INFO::Fitting model to feature number 359, F375
## 2025-04-15 21:40:00.565596 INFO::Fitting model to feature number 360, F376
## 2025-04-15 21:40:00.569922 INFO::Fitting model to feature number 361, F377
## 2025-04-15 21:40:00.574148 INFO::Fitting model to feature number 362, F378
## 2025-04-15 21:40:00.578273 INFO::Fitting model to feature number 363, F379
## 2025-04-15 21:40:00.582379 INFO::Fitting model to feature number 364, F380
## 2025-04-15 21:40:00.586594 INFO::Fitting model to feature number 365, F381
## 2025-04-15 21:40:00.591561 INFO::Fitting model to feature number 366, F382
## 2025-04-15 21:40:00.595873 INFO::Fitting model to feature number 367, F383
## 2025-04-15 21:40:00.600186 INFO::Fitting model to feature number 368, F384
## 2025-04-15 21:40:00.604511 INFO::Fitting model to feature number 369, F386
## 2025-04-15 21:40:00.608822 INFO::Fitting model to feature number 370, F387
## 2025-04-15 21:40:00.613184 INFO::Fitting model to feature number 371, F388
## 2025-04-15 21:40:00.617537 INFO::Fitting model to feature number 372, F389
## 2025-04-15 21:40:00.62187 INFO::Fitting model to feature number 373, F390
## 2025-04-15 21:40:00.626163 INFO::Fitting model to feature number 374, F391
## 2025-04-15 21:40:00.630405 INFO::Fitting model to feature number 375, F392
## 2025-04-15 21:40:00.634682 INFO::Fitting model to feature number 376, F393
## 2025-04-15 21:40:00.63897 INFO::Fitting model to feature number 377, F394
## 2025-04-15 21:40:00.643368 INFO::Fitting model to feature number 378, F395
## 2025-04-15 21:40:00.647693 INFO::Fitting model to feature number 379, F396
## 2025-04-15 21:40:00.651977 INFO::Fitting model to feature number 380, F397
## 2025-04-15 21:40:00.65623 INFO::Fitting model to feature number 381, F398
## 2025-04-15 21:40:00.660464 INFO::Fitting model to feature number 382, F399
## 2025-04-15 21:40:00.664691 INFO::Fitting model to feature number 383, F400
## 2025-04-15 21:40:00.668915 INFO::Fitting model to feature number 384, F401
## 2025-04-15 21:40:00.673133 INFO::Fitting model to feature number 385, F402
## 2025-04-15 21:40:00.677303 INFO::Fitting model to feature number 386, F403
## 2025-04-15 21:40:00.681475 INFO::Fitting model to feature number 387, F404
## 2025-04-15 21:40:00.685727 INFO::Fitting model to feature number 388, F406
## 2025-04-15 21:40:00.690632 INFO::Fitting model to feature number 389, F407
## 2025-04-15 21:40:00.6967 INFO::Fitting model to feature number 390, F408
## 2025-04-15 21:40:00.702826 INFO::Fitting model to feature number 391, F409
## 2025-04-15 21:40:00.709017 INFO::Fitting model to feature number 392, F410
## 2025-04-15 21:40:00.715393 INFO::Fitting model to feature number 393, F411
## 2025-04-15 21:40:00.722227 INFO::Fitting model to feature number 394, F412
## 2025-04-15 21:40:00.727236 INFO::Fitting model to feature number 395, F413
## 2025-04-15 21:40:00.731956 INFO::Fitting model to feature number 396, F414
## 2025-04-15 21:40:00.736415 INFO::Fitting model to feature number 397, F415
## 2025-04-15 21:40:00.740899 INFO::Fitting model to feature number 398, F416
## 2025-04-15 21:40:00.745328 INFO::Fitting model to feature number 399, F417
## 2025-04-15 21:40:00.749729 INFO::Fitting model to feature number 400, F418
## 2025-04-15 21:40:00.754223 INFO::Fitting model to feature number 401, F419
## 2025-04-15 21:40:00.758805 INFO::Fitting model to feature number 402, F420
## 2025-04-15 21:40:00.763385 INFO::Fitting model to feature number 403, F421
## 2025-04-15 21:40:00.767844 INFO::Fitting model to feature number 404, F422
## 2025-04-15 21:40:00.772742 INFO::Fitting model to feature number 405, F423
## 2025-04-15 21:40:00.778298 INFO::Fitting model to feature number 406, F425
## 2025-04-15 21:40:00.783545 INFO::Fitting model to feature number 407, F426
## 2025-04-15 21:40:00.788253 INFO::Fitting model to feature number 408, F428
## 2025-04-15 21:40:00.793518 INFO::Fitting model to feature number 409, F429
## 2025-04-15 21:40:00.798665 INFO::Fitting model to feature number 410, F430
## 2025-04-15 21:40:00.803415 INFO::Fitting model to feature number 411, F431
## 2025-04-15 21:40:00.808107 INFO::Fitting model to feature number 412, F432
## 2025-04-15 21:40:00.813064 INFO::Fitting model to feature number 413, F433
## 2025-04-15 21:40:00.817785 INFO::Fitting model to feature number 414, F434
## 2025-04-15 21:40:00.822645 INFO::Fitting model to feature number 415, F435
## 2025-04-15 21:40:00.827584 INFO::Fitting model to feature number 416, F436
## 2025-04-15 21:40:00.832231 INFO::Fitting model to feature number 417, F437
## 2025-04-15 21:40:00.836826 INFO::Fitting model to feature number 418, F438
## 2025-04-15 21:40:00.841501 INFO::Fitting model to feature number 419, F439
## 2025-04-15 21:40:00.846945 INFO::Fitting model to feature number 420, F440
## 2025-04-15 21:40:00.851677 INFO::Fitting model to feature number 421, F441
## 2025-04-15 21:40:00.857876 INFO::Fitting model to feature number 422, F442
## 2025-04-15 21:40:00.862742 INFO::Fitting model to feature number 423, F443
## 2025-04-15 21:40:00.86757 INFO::Fitting model to feature number 424, F444
## 2025-04-15 21:40:00.872462 INFO::Fitting model to feature number 425, F445
## 2025-04-15 21:40:00.877212 INFO::Fitting model to feature number 426, F446
## 2025-04-15 21:40:00.881908 INFO::Fitting model to feature number 427, F447
## 2025-04-15 21:40:00.886998 INFO::Fitting model to feature number 428, F448
## 2025-04-15 21:40:00.892082 INFO::Fitting model to feature number 429, F449
## 2025-04-15 21:40:00.896948 INFO::Fitting model to feature number 430, F450
## 2025-04-15 21:40:00.902923 INFO::Fitting model to feature number 431, F451
## 2025-04-15 21:40:00.907682 INFO::Fitting model to feature number 432, F452
## 2025-04-15 21:40:00.912443 INFO::Fitting model to feature number 433, F454
## 2025-04-15 21:40:00.917458 INFO::Fitting model to feature number 434, F455
## 2025-04-15 21:40:00.922107 INFO::Fitting model to feature number 435, F456
## 2025-04-15 21:40:00.926724 INFO::Fitting model to feature number 436, F457
## 2025-04-15 21:40:00.931346 INFO::Fitting model to feature number 437, F458
## 2025-04-15 21:40:00.935977 INFO::Fitting model to feature number 438, F459
## 2025-04-15 21:40:00.940522 INFO::Fitting model to feature number 439, F461
## 2025-04-15 21:40:00.9451 INFO::Fitting model to feature number 440, F462
## 2025-04-15 21:40:00.949711 INFO::Fitting model to feature number 441, F463
## 2025-04-15 21:40:00.954316 INFO::Fitting model to feature number 442, F464
## 2025-04-15 21:40:00.958923 INFO::Fitting model to feature number 443, F465
## 2025-04-15 21:40:00.963495 INFO::Fitting model to feature number 444, F466
## 2025-04-15 21:40:00.968178 INFO::Fitting model to feature number 445, F467
## 2025-04-15 21:40:00.972817 INFO::Fitting model to feature number 446, F468
## 2025-04-15 21:40:00.977432 INFO::Fitting model to feature number 447, F469
## 2025-04-15 21:40:00.982088 INFO::Fitting model to feature number 448, F470
## 2025-04-15 21:40:00.986714 INFO::Fitting model to feature number 449, F471
## 2025-04-15 21:40:00.991305 INFO::Fitting model to feature number 450, F474
## 2025-04-15 21:40:00.995939 INFO::Fitting model to feature number 451, F475
## 2025-04-15 21:40:01.000655 INFO::Fitting model to feature number 452, F476
## 2025-04-15 21:40:01.00531 INFO::Fitting model to feature number 453, F477
## 2025-04-15 21:40:01.009978 INFO::Fitting model to feature number 454, F478
## 2025-04-15 21:40:01.014659 INFO::Fitting model to feature number 455, F479
## 2025-04-15 21:40:01.019342 INFO::Fitting model to feature number 456, F480
## 2025-04-15 21:40:01.024041 INFO::Fitting model to feature number 457, F481
## 2025-04-15 21:40:01.029015 INFO::Fitting model to feature number 458, F482
## 2025-04-15 21:40:01.033901 INFO::Fitting model to feature number 459, F483
## 2025-04-15 21:40:01.038693 INFO::Fitting model to feature number 460, F484
## 2025-04-15 21:40:01.043393 INFO::Fitting model to feature number 461, F485
## 2025-04-15 21:40:01.048058 INFO::Fitting model to feature number 462, F486
## 2025-04-15 21:40:01.052706 INFO::Fitting model to feature number 463, F487
## 2025-04-15 21:40:01.057391 INFO::Fitting model to feature number 464, F488
## 2025-04-15 21:40:01.062259 INFO::Fitting model to feature number 465, F489
## 2025-04-15 21:40:01.067048 INFO::Fitting model to feature number 466, F490
## 2025-04-15 21:40:01.071799 INFO::Fitting model to feature number 467, F491
## 2025-04-15 21:40:01.076496 INFO::Fitting model to feature number 468, F492
## 2025-04-15 21:40:01.081141 INFO::Fitting model to feature number 469, F493
## 2025-04-15 21:40:01.085773 INFO::Fitting model to feature number 470, F494
## 2025-04-15 21:40:01.090463 INFO::Fitting model to feature number 471, F495
## 2025-04-15 21:40:01.095143 INFO::Fitting model to feature number 472, F496
## 2025-04-15 21:40:01.09996 INFO::Fitting model to feature number 473, F497
## 2025-04-15 21:40:01.104684 INFO::Fitting model to feature number 474, F498
## 2025-04-15 21:40:01.109408 INFO::Fitting model to feature number 475, F499
## 2025-04-15 21:40:01.114058 INFO::Fitting model to feature number 476, F500
## 2025-04-15 21:40:01.118781 INFO::Fitting model to feature number 477, F501
## 2025-04-15 21:40:01.123594 INFO::Fitting model to feature number 478, F502
## 2025-04-15 21:40:01.128531 INFO::Fitting model to feature number 479, F503
## 2025-04-15 21:40:01.133348 INFO::Fitting model to feature number 480, F504
## 2025-04-15 21:40:01.138152 INFO::Fitting model to feature number 481, F505
## 2025-04-15 21:40:01.145606 INFO::Fitting model to feature number 482, F506
## 2025-04-15 21:40:01.153843 INFO::Fitting model to feature number 483, F507
## 2025-04-15 21:40:01.162276 INFO::Fitting model to feature number 484, F508
## 2025-04-15 21:40:01.167911 INFO::Fitting model to feature number 485, F509
## 2025-04-15 21:40:01.172821 INFO::Fitting model to feature number 486, F510
## 2025-04-15 21:40:01.177534 INFO::Fitting model to feature number 487, F511
## 2025-04-15 21:40:01.182152 INFO::Fitting model to feature number 488, F512
## 2025-04-15 21:40:01.186739 INFO::Fitting model to feature number 489, F513
## 2025-04-15 21:40:01.191328 INFO::Fitting model to feature number 490, F514
## 2025-04-15 21:40:01.195882 INFO::Fitting model to feature number 491, F515
## 2025-04-15 21:40:01.200403 INFO::Fitting model to feature number 492, F516
## 2025-04-15 21:40:01.204897 INFO::Fitting model to feature number 493, F517
## 2025-04-15 21:40:01.209414 INFO::Fitting model to feature number 494, F518
## 2025-04-15 21:40:01.213921 INFO::Fitting model to feature number 495, F519
## 2025-04-15 21:40:01.218431 INFO::Fitting model to feature number 496, F520
## 2025-04-15 21:40:01.222885 INFO::Fitting model to feature number 497, F521
## 2025-04-15 21:40:01.22737 INFO::Fitting model to feature number 498, F522
## 2025-04-15 21:40:01.23188 INFO::Fitting model to feature number 499, F523
## 2025-04-15 21:40:01.236299 INFO::Fitting model to feature number 500, F524
## 2025-04-15 21:40:01.240708 INFO::Fitting model to feature number 501, F525
## 2025-04-15 21:40:01.245177 INFO::Fitting model to feature number 502, F526
## 2025-04-15 21:40:01.249826 INFO::Fitting model to feature number 503, F527
## 2025-04-15 21:40:01.254402 INFO::Fitting model to feature number 504, F528
## 2025-04-15 21:40:01.259033 INFO::Fitting model to feature number 505, F529
## 2025-04-15 21:40:01.263616 INFO::Fitting model to feature number 506, F530
## 2025-04-15 21:40:01.268096 INFO::Fitting model to feature number 507, F531
## 2025-04-15 21:40:01.272591 INFO::Fitting model to feature number 508, F532
## 2025-04-15 21:40:01.277104 INFO::Fitting model to feature number 509, F533
## 2025-04-15 21:40:01.281654 INFO::Fitting model to feature number 510, F534
## 2025-04-15 21:40:01.286147 INFO::Fitting model to feature number 511, F535
## 2025-04-15 21:40:01.290733 INFO::Fitting model to feature number 512, F536
## 2025-04-15 21:40:01.295254 INFO::Fitting model to feature number 513, F537
## 2025-04-15 21:40:01.299699 INFO::Fitting model to feature number 514, F539
## 2025-04-15 21:40:01.304163 INFO::Fitting model to feature number 515, F540
## 2025-04-15 21:40:01.308687 INFO::Fitting model to feature number 516, F541
## 2025-04-15 21:40:01.313222 INFO::Fitting model to feature number 517, F543
## 2025-04-15 21:40:01.320272 INFO::Fitting model to feature number 518, F544
## 2025-04-15 21:40:01.325061 INFO::Fitting model to feature number 519, F545
## 2025-04-15 21:40:01.330422 INFO::Fitting model to feature number 520, F546
## 2025-04-15 21:40:01.335726 INFO::Fitting model to feature number 521, F547
## 2025-04-15 21:40:01.340855 INFO::Fitting model to feature number 522, F548
## 2025-04-15 21:40:01.347289 INFO::Fitting model to feature number 523, F549
## 2025-04-15 21:40:01.352238 INFO::Fitting model to feature number 524, F550
## 2025-04-15 21:40:01.359253 INFO::Fitting model to feature number 525, F551
## 2025-04-15 21:40:01.367077 INFO::Fitting model to feature number 526, F552
## 2025-04-15 21:40:01.375145 INFO::Fitting model to feature number 527, F553
## 2025-04-15 21:40:01.3831 INFO::Fitting model to feature number 528, F554
## 2025-04-15 21:40:01.390884 INFO::Fitting model to feature number 529, F555
## 2025-04-15 21:40:01.398522 INFO::Fitting model to feature number 530, F556
## 2025-04-15 21:40:01.406175 INFO::Fitting model to feature number 531, F557
## 2025-04-15 21:40:01.413968 INFO::Fitting model to feature number 532, F558
## 2025-04-15 21:40:01.422112 INFO::Fitting model to feature number 533, F559
## 2025-04-15 21:40:01.429985 INFO::Fitting model to feature number 534, F560
## 2025-04-15 21:40:01.437641 INFO::Fitting model to feature number 535, F561
## 2025-04-15 21:40:01.445373 INFO::Fitting model to feature number 536, F562
## 2025-04-15 21:40:01.476075 INFO::Fitting model to feature number 537, F563
## 2025-04-15 21:40:01.481192 INFO::Fitting model to feature number 538, F564
## 2025-04-15 21:40:01.48569 INFO::Fitting model to feature number 539, F566
## 2025-04-15 21:40:01.490165 INFO::Fitting model to feature number 540, F567
## 2025-04-15 21:40:01.495079 INFO::Fitting model to feature number 541, F568
## 2025-04-15 21:40:01.500505 INFO::Fitting model to feature number 542, F569
## 2025-04-15 21:40:01.505045 INFO::Fitting model to feature number 543, F570
## 2025-04-15 21:40:01.510147 INFO::Fitting model to feature number 544, F571
## 2025-04-15 21:40:01.515981 INFO::Fitting model to feature number 545, F572
## 2025-04-15 21:40:01.52063 INFO::Fitting model to feature number 546, F573
## 2025-04-15 21:40:01.525128 INFO::Fitting model to feature number 547, F574
## 2025-04-15 21:40:01.529641 INFO::Fitting model to feature number 548, F575
## 2025-04-15 21:40:01.533991 INFO::Fitting model to feature number 549, F576
## 2025-04-15 21:40:01.538279 INFO::Fitting model to feature number 550, F577
## 2025-04-15 21:40:01.543394 INFO::Fitting model to feature number 551, F578
## 2025-04-15 21:40:01.547664 INFO::Fitting model to feature number 552, F579
## 2025-04-15 21:40:01.552101 INFO::Fitting model to feature number 553, F580
## 2025-04-15 21:40:01.557473 INFO::Fitting model to feature number 554, F581
## 2025-04-15 21:40:01.563689 INFO::Fitting model to feature number 555, F582
## 2025-04-15 21:40:01.568402 INFO::Fitting model to feature number 556, F583
## 2025-04-15 21:40:01.572962 INFO::Fitting model to feature number 557, F584
## 2025-04-15 21:40:01.577473 INFO::Fitting model to feature number 558, F585
## 2025-04-15 21:40:01.581866 INFO::Fitting model to feature number 559, F586
## 2025-04-15 21:40:01.586229 INFO::Fitting model to feature number 560, F587
## 2025-04-15 21:40:01.590657 INFO::Fitting model to feature number 561, F588
## 2025-04-15 21:40:01.594943 INFO::Fitting model to feature number 562, F589
## 2025-04-15 21:40:01.599256 INFO::Fitting model to feature number 563, F590
## 2025-04-15 21:40:01.603753 INFO::Fitting model to feature number 564, F591
## 2025-04-15 21:40:01.608159 INFO::Fitting model to feature number 565, F592
## 2025-04-15 21:40:01.61251 INFO::Fitting model to feature number 566, F593
## 2025-04-15 21:40:01.61688 INFO::Fitting model to feature number 567, F594
## 2025-04-15 21:40:01.621137 INFO::Fitting model to feature number 568, F595
## 2025-04-15 21:40:01.625343 INFO::Fitting model to feature number 569, F596
## 2025-04-15 21:40:01.629567 INFO::Fitting model to feature number 570, F597
## 2025-04-15 21:40:01.633799 INFO::Fitting model to feature number 571, F598
## 2025-04-15 21:40:01.638075 INFO::Fitting model to feature number 572, F599
## 2025-04-15 21:40:01.64228 INFO::Fitting model to feature number 573, F600
## 2025-04-15 21:40:01.646481 INFO::Fitting model to feature number 574, F601
## 2025-04-15 21:40:01.650675 INFO::Fitting model to feature number 575, F602
## 2025-04-15 21:40:01.654902 INFO::Fitting model to feature number 576, F603
## 2025-04-15 21:40:01.659144 INFO::Fitting model to feature number 577, F605
## 2025-04-15 21:40:01.663367 INFO::Fitting model to feature number 578, F606
## 2025-04-15 21:40:01.667509 INFO::Fitting model to feature number 579, F607
## 2025-04-15 21:40:01.671684 INFO::Fitting model to feature number 580, F608
## 2025-04-15 21:40:01.675849 INFO::Fitting model to feature number 581, F609
## 2025-04-15 21:40:01.679973 INFO::Fitting model to feature number 582, F610
## 2025-04-15 21:40:01.684283 INFO::Fitting model to feature number 583, F611
## 2025-04-15 21:40:01.688532 INFO::Fitting model to feature number 584, F612
## 2025-04-15 21:40:01.692892 INFO::Fitting model to feature number 585, F613
## 2025-04-15 21:40:01.697235 INFO::Fitting model to feature number 586, F614
## 2025-04-15 21:40:01.701621 INFO::Fitting model to feature number 587, F615
## 2025-04-15 21:40:01.70734 INFO::Fitting model to feature number 588, F616
## 2025-04-15 21:40:01.713632 INFO::Fitting model to feature number 589, F617
## 2025-04-15 21:40:01.720171 INFO::Fitting model to feature number 590, F618
## 2025-04-15 21:40:01.726999 INFO::Fitting model to feature number 591, F619
## 2025-04-15 21:40:01.732989 INFO::Fitting model to feature number 592, F620
## 2025-04-15 21:40:01.737672 INFO::Fitting model to feature number 593, F621
## 2025-04-15 21:40:01.742275 INFO::Fitting model to feature number 594, F622
## 2025-04-15 21:40:01.746925 INFO::Fitting model to feature number 595, F623
## 2025-04-15 21:40:01.751378 INFO::Fitting model to feature number 596, F624
## 2025-04-15 21:40:01.75574 INFO::Fitting model to feature number 597, F625
## 2025-04-15 21:40:01.760077 INFO::Fitting model to feature number 598, F626
## 2025-04-15 21:40:01.764575 INFO::Fitting model to feature number 599, F627
## 2025-04-15 21:40:01.768885 INFO::Fitting model to feature number 600, F628
## 2025-04-15 21:40:01.773198 INFO::Fitting model to feature number 601, F629
## 2025-04-15 21:40:01.777851 INFO::Fitting model to feature number 602, F630
## 2025-04-15 21:40:01.784308 INFO::Fitting model to feature number 603, F631
## 2025-04-15 21:40:01.791148 INFO::Fitting model to feature number 604, F632
## 2025-04-15 21:40:01.797746 INFO::Fitting model to feature number 605, F633
## 2025-04-15 21:40:01.804278 INFO::Fitting model to feature number 606, F634
## 2025-04-15 21:40:01.811165 INFO::Fitting model to feature number 607, F635
## 2025-04-15 21:40:01.817931 INFO::Fitting model to feature number 608, F636
## 2025-04-15 21:40:01.824605 INFO::Fitting model to feature number 609, F637
## 2025-04-15 21:40:01.831302 INFO::Fitting model to feature number 610, F638
## 2025-04-15 21:40:01.838012 INFO::Fitting model to feature number 611, F639
## 2025-04-15 21:40:01.844753 INFO::Fitting model to feature number 612, F640
## 2025-04-15 21:40:01.851763 INFO::Fitting model to feature number 613, F641
## 2025-04-15 21:40:01.858642 INFO::Fitting model to feature number 614, F642
## 2025-04-15 21:40:01.865414 INFO::Fitting model to feature number 615, F643
## 2025-04-15 21:40:01.872271 INFO::Fitting model to feature number 616, F644
## 2025-04-15 21:40:01.879113 INFO::Fitting model to feature number 617, F645
## 2025-04-15 21:40:01.886048 INFO::Fitting model to feature number 618, F646
## 2025-04-15 21:40:01.893131 INFO::Fitting model to feature number 619, F647
## 2025-04-15 21:40:01.897799 INFO::Fitting model to feature number 620, F648
## 2025-04-15 21:40:01.902421 INFO::Fitting model to feature number 621, F649
## 2025-04-15 21:40:01.907232 INFO::Fitting model to feature number 622, F650
## 2025-04-15 21:40:01.911821 INFO::Fitting model to feature number 623, F651
## 2025-04-15 21:40:01.916224 INFO::Fitting model to feature number 624, F652
## 2025-04-15 21:40:01.92071 INFO::Fitting model to feature number 625, F653
## 2025-04-15 21:40:01.925185 INFO::Fitting model to feature number 626, F654
## 2025-04-15 21:40:01.929604 INFO::Fitting model to feature number 627, F655
## 2025-04-15 21:40:01.935494 INFO::Fitting model to feature number 628, F656
## 2025-04-15 21:40:01.942828 INFO::Fitting model to feature number 629, F657
## 2025-04-15 21:40:01.950224 INFO::Fitting model to feature number 630, F658
## 2025-04-15 21:40:01.957257 INFO::Fitting model to feature number 631, F659
## 2025-04-15 21:40:01.964898 INFO::Fitting model to feature number 632, F660
## 2025-04-15 21:40:01.971927 INFO::Fitting model to feature number 633, F661
## 2025-04-15 21:40:01.978696 INFO::Fitting model to feature number 634, F662
## 2025-04-15 21:40:01.985378 INFO::Fitting model to feature number 635, F663
## 2025-04-15 21:40:01.989876 INFO::Fitting model to feature number 636, F664
## 2025-04-15 21:40:01.994451 INFO::Fitting model to feature number 637, F665
## 2025-04-15 21:40:01.998968 INFO::Fitting model to feature number 638, F666
## 2025-04-15 21:40:02.005163 INFO::Fitting model to feature number 639, F667
## 2025-04-15 21:40:02.009698 INFO::Fitting model to feature number 640, F668
## 2025-04-15 21:40:02.014295 INFO::Fitting model to feature number 641, F669
## 2025-04-15 21:40:02.018806 INFO::Fitting model to feature number 642, F670
## 2025-04-15 21:40:02.023175 INFO::Fitting model to feature number 643, F671
## 2025-04-15 21:40:02.027615 INFO::Fitting model to feature number 644, F672
## 2025-04-15 21:40:02.032021 INFO::Fitting model to feature number 645, F673
## 2025-04-15 21:40:02.0366 INFO::Fitting model to feature number 646, F674
## 2025-04-15 21:40:02.041097 INFO::Fitting model to feature number 647, F675
## 2025-04-15 21:40:02.045554 INFO::Fitting model to feature number 648, F676
## 2025-04-15 21:40:02.050094 INFO::Fitting model to feature number 649, F677
## 2025-04-15 21:40:02.054622 INFO::Fitting model to feature number 650, F678
## 2025-04-15 21:40:02.059091 INFO::Fitting model to feature number 651, F679
## 2025-04-15 21:40:02.064055 INFO::Fitting model to feature number 652, F680
## 2025-04-15 21:40:02.069341 INFO::Fitting model to feature number 653, F681
## 2025-04-15 21:40:02.07423 INFO::Fitting model to feature number 654, F682
## 2025-04-15 21:40:02.078875 INFO::Fitting model to feature number 655, F683
## 2025-04-15 21:40:02.083361 INFO::Fitting model to feature number 656, F684
## 2025-04-15 21:40:02.087883 INFO::Fitting model to feature number 657, F685
## 2025-04-15 21:40:02.092359 INFO::Fitting model to feature number 658, F686
## 2025-04-15 21:40:02.096784 INFO::Fitting model to feature number 659, F687
## 2025-04-15 21:40:02.10128 INFO::Fitting model to feature number 660, F688
## 2025-04-15 21:40:02.105921 INFO::Fitting model to feature number 661, F689
## 2025-04-15 21:40:02.110646 INFO::Fitting model to feature number 662, F690
## 2025-04-15 21:40:02.115218 INFO::Fitting model to feature number 663, F691
## 2025-04-15 21:40:02.119697 INFO::Fitting model to feature number 664, F692
## 2025-04-15 21:40:02.124219 INFO::Fitting model to feature number 665, F693
## 2025-04-15 21:40:02.128884 INFO::Fitting model to feature number 666, F694
## 2025-04-15 21:40:02.133469 INFO::Fitting model to feature number 667, F695
## 2025-04-15 21:40:02.138134 INFO::Fitting model to feature number 668, F696
## 2025-04-15 21:40:02.142864 INFO::Fitting model to feature number 669, F697
## 2025-04-15 21:40:02.147682 INFO::Fitting model to feature number 670, F698
## 2025-04-15 21:40:02.152389 INFO::Fitting model to feature number 671, F699
## 2025-04-15 21:40:02.159433 INFO::Fitting model to feature number 672, F700
## 2025-04-15 21:40:02.166882 INFO::Fitting model to feature number 673, F701
## 2025-04-15 21:40:02.174738 INFO::Fitting model to feature number 674, F702
## 2025-04-15 21:40:02.183204 INFO::Fitting model to feature number 675, F704
## 2025-04-15 21:40:02.191448 INFO::Fitting model to feature number 676, F705
## 2025-04-15 21:40:02.197154 INFO::Fitting model to feature number 677, F706
## 2025-04-15 21:40:02.201965 INFO::Fitting model to feature number 678, F707
## 2025-04-15 21:40:02.206659 INFO::Fitting model to feature number 679, F708
## 2025-04-15 21:40:02.211246 INFO::Fitting model to feature number 680, F709
## 2025-04-15 21:40:02.217242 INFO::Fitting model to feature number 681, F710
## 2025-04-15 21:40:02.222288 INFO::Fitting model to feature number 682, F711
## 2025-04-15 21:40:02.226861 INFO::Fitting model to feature number 683, F712
## 2025-04-15 21:40:02.232022 INFO::Fitting model to feature number 684, F713
## 2025-04-15 21:40:02.236582 INFO::Fitting model to feature number 685, F714
## 2025-04-15 21:40:02.241105 INFO::Fitting model to feature number 686, F715
## 2025-04-15 21:40:02.245643 INFO::Fitting model to feature number 687, F716
## 2025-04-15 21:40:02.250226 INFO::Fitting model to feature number 688, F717
## 2025-04-15 21:40:02.254662 INFO::Fitting model to feature number 689, F718
## 2025-04-15 21:40:02.259055 INFO::Fitting model to feature number 690, F719
## 2025-04-15 21:40:02.263446 INFO::Fitting model to feature number 691, F720
## 2025-04-15 21:40:02.267791 INFO::Fitting model to feature number 692, F721
## 2025-04-15 21:40:02.27216 INFO::Fitting model to feature number 693, F722
## 2025-04-15 21:40:02.27672 INFO::Fitting model to feature number 694, F723
## 2025-04-15 21:40:02.281212 INFO::Fitting model to feature number 695, F724
## 2025-04-15 21:40:02.285863 INFO::Fitting model to feature number 696, F725
## 2025-04-15 21:40:02.290759 INFO::Fitting model to feature number 697, F726
## 2025-04-15 21:40:02.295683 INFO::Fitting model to feature number 698, F727
## 2025-04-15 21:40:02.30047 INFO::Fitting model to feature number 699, F728
## 2025-04-15 21:40:02.305072 INFO::Fitting model to feature number 700, F729
## 2025-04-15 21:40:02.309753 INFO::Fitting model to feature number 701, F730
## 2025-04-15 21:40:02.314256 INFO::Fitting model to feature number 702, F731
## 2025-04-15 21:40:02.318753 INFO::Fitting model to feature number 703, F732
## 2025-04-15 21:40:02.323336 INFO::Fitting model to feature number 704, F733
## 2025-04-15 21:40:02.327882 INFO::Fitting model to feature number 705, F734
## 2025-04-15 21:40:02.332411 INFO::Fitting model to feature number 706, F735
## 2025-04-15 21:40:02.336893 INFO::Fitting model to feature number 707, F736
## 2025-04-15 21:40:02.341406 INFO::Fitting model to feature number 708, F737
## 2025-04-15 21:40:02.345895 INFO::Fitting model to feature number 709, F739
## 2025-04-15 21:40:02.350475 INFO::Fitting model to feature number 710, F740
## 2025-04-15 21:40:02.354987 INFO::Fitting model to feature number 711, F741
## 2025-04-15 21:40:02.359616 INFO::Fitting model to feature number 712, F742
## 2025-04-15 21:40:02.364173 INFO::Fitting model to feature number 713, F743
## 2025-04-15 21:40:02.368709 INFO::Fitting model to feature number 714, F744
## 2025-04-15 21:40:02.373478 INFO::Fitting model to feature number 715, F745
## 2025-04-15 21:40:02.378112 INFO::Fitting model to feature number 716, F746
## 2025-04-15 21:40:02.382755 INFO::Fitting model to feature number 717, F747
## 2025-04-15 21:40:02.387511 INFO::Fitting model to feature number 718, F748
## 2025-04-15 21:40:02.392197 INFO::Fitting model to feature number 719, F749
## 2025-04-15 21:40:02.396866 INFO::Fitting model to feature number 720, F750
## 2025-04-15 21:40:02.401569 INFO::Fitting model to feature number 721, F751
## 2025-04-15 21:40:02.406114 INFO::Fitting model to feature number 722, F752
## 2025-04-15 21:40:02.410656 INFO::Fitting model to feature number 723, F753
## 2025-04-15 21:40:02.415085 INFO::Fitting model to feature number 724, F754
## 2025-04-15 21:40:02.419657 INFO::Fitting model to feature number 725, F755
## 2025-04-15 21:40:02.424312 INFO::Fitting model to feature number 726, F756
## 2025-04-15 21:40:02.429058 INFO::Fitting model to feature number 727, F757
## 2025-04-15 21:40:02.433837 INFO::Fitting model to feature number 728, F758
## 2025-04-15 21:40:02.438813 INFO::Fitting model to feature number 729, F759
## 2025-04-15 21:40:02.443272 INFO::Fitting model to feature number 730, F760
## 2025-04-15 21:40:02.447933 INFO::Fitting model to feature number 731, F761
## 2025-04-15 21:40:02.452998 INFO::Fitting model to feature number 732, F762
## 2025-04-15 21:40:02.45794 INFO::Fitting model to feature number 733, F763
## 2025-04-15 21:40:02.462911 INFO::Fitting model to feature number 734, F764
## 2025-04-15 21:40:02.467766 INFO::Fitting model to feature number 735, F765
## 2025-04-15 21:40:02.47251 INFO::Fitting model to feature number 736, F766
## 2025-04-15 21:40:02.477355 INFO::Fitting model to feature number 737, F767
## 2025-04-15 21:40:02.482598 INFO::Fitting model to feature number 738, F768
## 2025-04-15 21:40:02.488109 INFO::Fitting model to feature number 739, F769
## 2025-04-15 21:40:02.493099 INFO::Fitting model to feature number 740, F770
## 2025-04-15 21:40:02.498205 INFO::Fitting model to feature number 741, F771
## 2025-04-15 21:40:02.503337 INFO::Fitting model to feature number 742, F772
## 2025-04-15 21:40:02.508548 INFO::Fitting model to feature number 743, F773
## 2025-04-15 21:40:02.51521 INFO::Fitting model to feature number 744, F774
## 2025-04-15 21:40:02.523922 INFO::Fitting model to feature number 745, F775
## 2025-04-15 21:40:02.53035 INFO::Fitting model to feature number 746, F776
## 2025-04-15 21:40:02.535085 INFO::Fitting model to feature number 747, F777
## 2025-04-15 21:40:02.540227 INFO::Fitting model to feature number 748, F778
## 2025-04-15 21:40:02.545847 INFO::Fitting model to feature number 749, F779
## 2025-04-15 21:40:02.550586 INFO::Fitting model to feature number 750, F780
## 2025-04-15 21:40:02.555292 INFO::Fitting model to feature number 751, F781
## 2025-04-15 21:40:02.560343 INFO::Fitting model to feature number 752, F782
## 2025-04-15 21:40:02.56581 INFO::Fitting model to feature number 753, F783
## 2025-04-15 21:40:02.573393 INFO::Fitting model to feature number 754, F784
## 2025-04-15 21:40:02.5811 INFO::Fitting model to feature number 755, F785
## 2025-04-15 21:40:02.588703 INFO::Fitting model to feature number 756, F786
## 2025-04-15 21:40:02.596328 INFO::Fitting model to feature number 757, F787
## 2025-04-15 21:40:02.604 INFO::Fitting model to feature number 758, F788
## 2025-04-15 21:40:02.61165 INFO::Fitting model to feature number 759, F789
## 2025-04-15 21:40:02.619202 INFO::Fitting model to feature number 760, F790
## 2025-04-15 21:40:02.626543 INFO::Fitting model to feature number 761, F791
## 2025-04-15 21:40:02.633912 INFO::Fitting model to feature number 762, F792
## 2025-04-15 21:40:02.641495 INFO::Fitting model to feature number 763, F793
## 2025-04-15 21:40:02.649176 INFO::Fitting model to feature number 764, F794
## 2025-04-15 21:40:02.656782 INFO::Fitting model to feature number 765, F795
## 2025-04-15 21:40:02.663716 INFO::Fitting model to feature number 766, F796
## 2025-04-15 21:40:02.670732 INFO::Fitting model to feature number 767, F797
## 2025-04-15 21:40:02.677958 INFO::Fitting model to feature number 768, F798
## 2025-04-15 21:40:02.685386 INFO::Fitting model to feature number 769, F799
## 2025-04-15 21:40:02.693568 INFO::Fitting model to feature number 770, F800
## 2025-04-15 21:40:02.701152 INFO::Fitting model to feature number 771, F801
## 2025-04-15 21:40:02.708914 INFO::Fitting model to feature number 772, F802
## 2025-04-15 21:40:02.716063 INFO::Fitting model to feature number 773, F803
## 2025-04-15 21:40:02.723191 INFO::Fitting model to feature number 774, F804
## 2025-04-15 21:40:02.730256 INFO::Fitting model to feature number 775, F805
## 2025-04-15 21:40:02.737374 INFO::Fitting model to feature number 776, F806
## 2025-04-15 21:40:02.74498 INFO::Fitting model to feature number 777, F808
## 2025-04-15 21:40:02.752685 INFO::Fitting model to feature number 778, F809
## 2025-04-15 21:40:02.760317 INFO::Fitting model to feature number 779, F810
## 2025-04-15 21:40:02.767727 INFO::Fitting model to feature number 780, F811
## 2025-04-15 21:40:02.775026 INFO::Fitting model to feature number 781, F812
## 2025-04-15 21:40:02.782317 INFO::Fitting model to feature number 782, F813
## 2025-04-15 21:40:02.789687 INFO::Fitting model to feature number 783, F814
## 2025-04-15 21:40:02.797139 INFO::Fitting model to feature number 784, F815
## 2025-04-15 21:40:02.804501 INFO::Fitting model to feature number 785, F816
## 2025-04-15 21:40:02.811929 INFO::Fitting model to feature number 786, F817
## 2025-04-15 21:40:02.81938 INFO::Fitting model to feature number 787, F818
## 2025-04-15 21:40:02.82671 INFO::Fitting model to feature number 788, F819
## 2025-04-15 21:40:02.833901 INFO::Fitting model to feature number 789, F820
## 2025-04-15 21:40:02.841564 INFO::Fitting model to feature number 790, F821
## 2025-04-15 21:40:02.849704 INFO::Fitting model to feature number 791, F822
## 2025-04-15 21:40:02.857144 INFO::Fitting model to feature number 792, F823
## 2025-04-15 21:40:02.86194 INFO::Fitting model to feature number 793, F824
## 2025-04-15 21:40:02.866693 INFO::Fitting model to feature number 794, F825
## 2025-04-15 21:40:02.871526 INFO::Fitting model to feature number 795, F826
## 2025-04-15 21:40:02.876254 INFO::Fitting model to feature number 796, F827
## 2025-04-15 21:40:02.880965 INFO::Fitting model to feature number 797, F828
## 2025-04-15 21:40:02.885902 INFO::Fitting model to feature number 798, F829
## 2025-04-15 21:40:02.890755 INFO::Fitting model to feature number 799, F830
## 2025-04-15 21:40:02.895499 INFO::Fitting model to feature number 800, F831
## 2025-04-15 21:40:02.900199 INFO::Fitting model to feature number 801, F832
## 2025-04-15 21:40:02.905003 INFO::Fitting model to feature number 802, F833
## 2025-04-15 21:40:02.90984 INFO::Fitting model to feature number 803, F834
## 2025-04-15 21:40:02.914814 INFO::Fitting model to feature number 804, F835
## 2025-04-15 21:40:02.92009 INFO::Fitting model to feature number 805, F836
## 2025-04-15 21:40:02.925307 INFO::Fitting model to feature number 806, F837
## 2025-04-15 21:40:02.930632 INFO::Fitting model to feature number 807, F838
## 2025-04-15 21:40:02.937174 INFO::Fitting model to feature number 808, F839
## 2025-04-15 21:40:02.942057 INFO::Fitting model to feature number 809, F840
## 2025-04-15 21:40:02.94744 INFO::Fitting model to feature number 810, F841
## 2025-04-15 21:40:02.95278 INFO::Fitting model to feature number 811, F842
## 2025-04-15 21:40:02.958146 INFO::Fitting model to feature number 812, F843
## 2025-04-15 21:40:02.96452 INFO::Fitting model to feature number 813, F844
## 2025-04-15 21:40:02.971683 INFO::Fitting model to feature number 814, F845
## 2025-04-15 21:40:02.9776 INFO::Fitting model to feature number 815, F846
## 2025-04-15 21:40:02.985111 INFO::Fitting model to feature number 816, F847
## 2025-04-15 21:40:02.992775 INFO::Fitting model to feature number 817, F848
## 2025-04-15 21:40:03.000419 INFO::Fitting model to feature number 818, F849
## 2025-04-15 21:40:03.008012 INFO::Fitting model to feature number 819, F850
## 2025-04-15 21:40:03.01562 INFO::Fitting model to feature number 820, F851
## 2025-04-15 21:40:03.023313 INFO::Fitting model to feature number 821, F852
## 2025-04-15 21:40:03.030995 INFO::Fitting model to feature number 822, F853
## 2025-04-15 21:40:03.038672 INFO::Fitting model to feature number 823, F854
## 2025-04-15 21:40:03.046483 INFO::Fitting model to feature number 824, F855
## 2025-04-15 21:40:03.054122 INFO::Fitting model to feature number 825, F856
## 2025-04-15 21:40:03.061735 INFO::Fitting model to feature number 826, F857
## 2025-04-15 21:40:03.069384 INFO::Fitting model to feature number 827, F858
## 2025-04-15 21:40:03.076997 INFO::Fitting model to feature number 828, F859
## 2025-04-15 21:40:03.084099 INFO::Fitting model to feature number 829, F860
## 2025-04-15 21:40:03.088954 INFO::Fitting model to feature number 830, F861
## 2025-04-15 21:40:03.093885 INFO::Fitting model to feature number 831, F862
## 2025-04-15 21:40:03.099957 INFO::Fitting model to feature number 832, F863
## 2025-04-15 21:40:03.10721 INFO::Fitting model to feature number 833, F864
## 2025-04-15 21:40:03.112053 INFO::Fitting model to feature number 834, F865
## 2025-04-15 21:40:03.117187 INFO::Fitting model to feature number 835, F866
## 2025-04-15 21:40:03.122213 INFO::Fitting model to feature number 836, F867
## 2025-04-15 21:40:03.131667 INFO::Fitting model to feature number 837, F868
## 2025-04-15 21:40:03.136705 INFO::Fitting model to feature number 838, F869
## 2025-04-15 21:40:03.14174 INFO::Fitting model to feature number 839, F870
## 2025-04-15 21:40:03.14673 INFO::Fitting model to feature number 840, F871
## 2025-04-15 21:40:03.151633 INFO::Fitting model to feature number 841, F872
## 2025-04-15 21:40:03.158244 INFO::Fitting model to feature number 842, F873
## 2025-04-15 21:40:03.165143 INFO::Fitting model to feature number 843, F874
## 2025-04-15 21:40:03.172185 INFO::Fitting model to feature number 844, F875
## 2025-04-15 21:40:03.179289 INFO::Fitting model to feature number 845, F876
## 2025-04-15 21:40:03.185883 INFO::Fitting model to feature number 846, F877
## 2025-04-15 21:40:03.190816 INFO::Fitting model to feature number 847, F878
## 2025-04-15 21:40:03.195754 INFO::Fitting model to feature number 848, F879
## 2025-04-15 21:40:03.201355 INFO::Fitting model to feature number 849, F880
## 2025-04-15 21:40:03.208487 INFO::Fitting model to feature number 850, F881
## 2025-04-15 21:40:03.21611 INFO::Fitting model to feature number 851, F882
## 2025-04-15 21:40:03.221262 INFO::Fitting model to feature number 852, F883
## 2025-04-15 21:40:03.248941 INFO::Fitting model to feature number 853, F884
## 2025-04-15 21:40:03.254193 INFO::Fitting model to feature number 854, F885
## 2025-04-15 21:40:03.260152 INFO::Fitting model to feature number 855, F886
## 2025-04-15 21:40:03.264701 INFO::Fitting model to feature number 856, F887
## 2025-04-15 21:40:03.269297 INFO::Fitting model to feature number 857, F888
## 2025-04-15 21:40:03.273868 INFO::Fitting model to feature number 858, F889
## 2025-04-15 21:40:03.278581 INFO::Fitting model to feature number 859, F890
## 2025-04-15 21:40:03.283039 INFO::Fitting model to feature number 860, F891
## 2025-04-15 21:40:03.288334 INFO::Fitting model to feature number 861, F892
## 2025-04-15 21:40:03.293166 INFO::Fitting model to feature number 862, F893
## 2025-04-15 21:40:03.297689 INFO::Fitting model to feature number 863, F894
## 2025-04-15 21:40:03.302472 INFO::Fitting model to feature number 864, F895
## 2025-04-15 21:40:03.306867 INFO::Fitting model to feature number 865, F896
## 2025-04-15 21:40:03.311303 INFO::Fitting model to feature number 866, F897
## 2025-04-15 21:40:03.315743 INFO::Fitting model to feature number 867, F898
## 2025-04-15 21:40:03.320217 INFO::Fitting model to feature number 868, F899
## 2025-04-15 21:40:03.324601 INFO::Fitting model to feature number 869, F900
## 2025-04-15 21:40:03.566683 INFO::Counting total values for each feature
## 2025-04-15 21:40:03.744099 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2025-04-15 21:40:04.02425 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2025-04-15 21:40:04.320168 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2025-04-15 21:40:04.578341 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2025-04-15 21:40:04.619368 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2025-04-15 21:40:04.650678 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2025-04-15 21:40:04.70428 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2025-04-15 21:40:04.729374 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2025-04-15 21:40:05.262471 INFO::Plotting associations from most to least significant, grouped by metadata
## 2025-04-15 21:40:05.264551 INFO::Plotting data for metadata number 1, diagnosis
## 2025-04-15 21:40:05.320023 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2025-04-15 21:40:05.853308 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2025-04-15 21:40:06.180575 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2025-04-15 21:40:06.407074 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2025-04-15 21:40:06.591804 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2025-04-15 21:40:06.763293 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2025-04-15 21:40:06.935332 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2025-04-15 21:40:07.147285 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2025-04-15 21:40:07.369451 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2025-04-15 21:40:07.563337 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2025-04-15 21:40:07.854284 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2025-04-15 21:40:08.162807 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2025-04-15 21:40:08.470572 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2025-04-15 21:40:08.718228 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2025-04-15 21:40:08.926975 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2025-04-15 21:40:09.145839 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2025-04-15 21:40:09.385744 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2025-04-15 21:40:09.682214 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2025-04-15 21:40:09.974569 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2025-04-15 21:40:10.224643 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2025-04-15 21:40:10.490456 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2025-04-15 21:40:10.687875 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2025-04-15 21:40:10.910965 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2025-04-15 21:40:11.132449 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2025-04-15 21:40:11.330836 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2025-04-15 21:40:11.509711 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2025-04-15 21:40:11.686961 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2025-04-15 21:40:11.874469 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2025-04-15 21:40:12.094182 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2025-04-15 21:40:12.317287 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2025-04-15 21:40:12.572241 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2025-04-15 21:40:12.790409 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2025-04-15 21:40:12.970049 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2025-04-15 21:40:13.211884 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2025-04-15 21:40:13.463423 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2025-04-15 21:40:13.73009 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2025-04-15 21:40:13.972766 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2025-04-15 21:40:14.277462 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2025-04-15 21:40:14.548059 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2025-04-15 21:40:14.831418 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2025-04-15 21:40:15.053567 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2025-04-15 21:40:15.272782 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2025-04-15 21:40:15.49515 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2025-04-15 21:40:15.724624 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2025-04-15 21:40:15.93747 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2025-04-15 21:40:16.253231 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2025-04-15 21:40:16.471416 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2025-04-15 21:40:16.66594 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2025-04-15 21:40:16.869398 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2025-04-15 21:40:17.054296 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2025-04-15 21:40:17.244473 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2025-04-15 21:40:17.428052 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2025-04-15 21:40:17.61383 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2025-04-15 21:40:17.813899 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2025-04-15 21:40:17.996142 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2025-04-15 21:40:18.182251 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2025-04-15 21:40:18.37148 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2025-04-15 21:40:18.575596 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2025-04-15 21:40:18.763954 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2025-04-15 21:40:18.948864 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2025-04-15 21:40:19.13949 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2025-04-15 21:40:19.340647 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2025-04-15 21:40:19.565688 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2025-04-15 21:40:19.752385 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2025-04-15 21:40:19.95829 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2025-04-15 21:40:20.184698 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2025-04-15 21:40:20.430022 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2025-04-15 21:40:20.705036 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2025-04-15 21:40:20.881434 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2025-04-15 21:40:21.053438 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2025-04-15 21:40:21.254715 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2025-04-15 21:40:21.456551 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2025-04-15 21:40:21.653518 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2025-04-15 21:40:21.843265 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2025-04-15 21:40:22.047264 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2025-04-15 21:40:22.22573 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2025-04-15 21:40:22.397767 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2025-04-15 21:40:22.589426 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2025-04-15 21:40:22.767974 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2025-04-15 21:40:22.943428 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2025-04-15 21:40:23.188007 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2025-04-15 21:40:23.361255 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2025-04-15 21:40:23.625366 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2025-04-15 21:40:23.814977 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2025-04-15 21:40:23.99843 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2025-04-15 21:40:24.170476 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2025-04-15 21:40:24.345434 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2025-04-15 21:40:24.534943 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2025-04-15 21:40:24.705101 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2025-04-15 21:40:24.876446 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2025-04-15 21:40:25.049248 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2025-04-15 21:40:25.281193 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2025-04-15 21:40:25.567118 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2025-04-15 21:40:25.789587 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2025-04-15 21:40:26.032367 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2025-04-15 21:40:26.243933 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2025-04-15 21:40:26.525326 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2025-04-15 21:40:26.809842 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2025-04-15 21:40:27.007923 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2025-04-15 21:40:27.304693 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2025-04-15 21:40:27.597267 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2025-04-15 21:40:27.904991 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2025-04-15 21:40:28.188661 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2025-04-15 21:40:28.377748 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2025-04-15 21:40:28.608115 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2025-04-15 21:40:28.865492 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2025-04-15 21:40:29.151599 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2025-04-15 21:40:29.412319 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2025-04-15 21:40:29.605876 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2025-04-15 21:40:29.78051 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2025-04-15 21:40:29.959399 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2025-04-15 21:40:30.160417 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2025-04-15 21:40:30.411761 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2025-04-15 21:40:30.619332 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2025-04-15 21:40:30.80118 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2025-04-15 21:40:31.026902 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2025-04-15 21:40:31.228753 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2025-04-15 21:40:31.400495 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2025-04-15 21:40:31.577362 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2025-04-15 21:40:31.750611 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2025-04-15 21:40:32.016329 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2025-04-15 21:40:32.220309 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2025-04-15 21:40:32.487147 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2025-04-15 21:40:32.754133 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2025-04-15 21:40:33.045791 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2025-04-15 21:40:33.297139 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2025-04-15 21:40:33.550995 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2025-04-15 21:40:33.838719 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2025-04-15 21:40:34.058997 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2025-04-15 21:40:34.304022 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2025-04-15 21:40:34.586548 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2025-04-15 21:40:34.823924 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2025-04-15 21:40:35.011559 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2025-04-15 21:40:35.235582 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2025-04-15 21:40:35.415079 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2025-04-15 21:40:35.621102 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2025-04-15 21:40:35.813691 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2025-04-15 21:40:36.006278 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2025-04-15 21:40:36.269736 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2025-04-15 21:40:36.544015 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2025-04-15 21:40:36.833249 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2025-04-15 21:40:37.135696 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2025-04-15 21:40:37.414381 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2025-04-15 21:40:37.671045 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2025-04-15 21:40:37.922682 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2025-04-15 21:40:38.181148 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2025-04-15 21:40:38.447013 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2025-04-15 21:40:38.726886 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2025-04-15 21:40:38.908154 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2025-04-15 21:40:39.087779 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2025-04-15 21:40:39.295677 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2025-04-15 21:40:39.501488 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2025-04-15 21:40:39.716771 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2025-04-15 21:40:39.90544 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2025-04-15 21:40:40.095157 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2025-04-15 21:40:40.305418 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2025-04-15 21:40:40.484618 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2025-04-15 21:40:40.676882 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2025-04-15 21:40:40.862368 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2025-04-15 21:40:41.034792 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2025-04-15 21:40:41.2462 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2025-04-15 21:40:41.425554 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2025-04-15 21:40:41.604653 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2025-04-15 21:40:41.828598 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2025-04-15 21:40:42.126996 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2025-04-15 21:40:42.45253 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2025-04-15 21:40:42.744874 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2025-04-15 21:40:43.036857 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2025-04-15 21:40:43.310819 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2025-04-15 21:40:43.491085 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2025-04-15 21:40:43.715889 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2025-04-15 21:40:43.958909 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2025-04-15 21:40:44.191761 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2025-04-15 21:40:44.411166 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2025-04-15 21:40:44.58908 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2025-04-15 21:40:44.878026 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2025-04-15 21:40:45.139343 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2025-04-15 21:40:45.38365 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2025-04-15 21:40:45.610717 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2025-04-15 21:40:45.884581 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2025-04-15 21:40:46.201141 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2025-04-15 21:40:46.468003 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2025-04-15 21:40:46.639838 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2025-04-15 21:40:46.811608 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2025-04-15 21:40:47.024408 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2025-04-15 21:40:47.204496 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2025-04-15 21:40:47.382053 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2025-04-15 21:40:47.614795 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2025-04-15 21:40:47.815277 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2025-04-15 21:40:48.022016 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2025-04-15 21:40:48.220075 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2025-04-15 21:40:48.469857 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2025-04-15 21:40:48.671204 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2025-04-15 21:40:48.868825 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2025-04-15 21:40:49.096294 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2025-04-15 21:40:49.294277 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2025-04-15 21:40:49.501318 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2025-04-15 21:40:49.680085 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2025-04-15 21:40:49.856556 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2025-04-15 21:40:50.050567 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2025-04-15 21:40:50.24369 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2025-04-15 21:40:50.435123 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2025-04-15 21:40:50.614542 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2025-04-15 21:40:50.788845 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2025-04-15 21:40:50.988279 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2025-04-15 21:40:51.168295 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2025-04-15 21:40:51.348648 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2025-04-15 21:40:51.587754 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2025-04-15 21:40:51.875309 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2025-04-15 21:40:52.12645 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2025-04-15 21:40:52.302504 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2025-04-15 21:40:52.498241 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2025-04-15 21:40:52.792153 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2025-04-15 21:40:53.107693 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2025-04-15 21:40:53.305638 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2025-04-15 21:40:53.476154 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2025-04-15 21:40:53.728727 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2025-04-15 21:40:54.024244 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2025-04-15 21:40:54.263191 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2025-04-15 21:40:54.506773 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2025-04-15 21:40:54.767338 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2025-04-15 21:40:55.000641 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2025-04-15 21:40:55.190001 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2025-04-15 21:40:55.572006 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2025-04-15 21:40:55.761897 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2025-04-15 21:40:55.985785 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2025-04-15 21:40:56.28814 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2025-04-15 21:40:56.567742 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2025-04-15 21:40:56.886842 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2025-04-15 21:40:57.071998 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2025-04-15 21:40:57.320143 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2025-04-15 21:40:57.498315 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2025-04-15 21:40:57.668753 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2025-04-15 21:40:57.886662 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2025-04-15 21:40:58.187924 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2025-04-15 21:40:58.463232 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2025-04-15 21:40:58.713669 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2025-04-15 21:40:58.955197 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2025-04-15 21:40:59.209067 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2025-04-15 21:40:59.39636 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2025-04-15 21:40:59.586777 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2025-04-15 21:40:59.831375 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2025-04-15 21:41:00.152247 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2025-04-15 21:41:00.460111 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2025-04-15 21:41:00.753873 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2025-04-15 21:41:01.044846 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2025-04-15 21:41:01.315711 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2025-04-15 21:41:01.646143 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2025-04-15 21:41:01.889205 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2025-04-15 21:41:02.069343 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2025-04-15 21:41:02.333929 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2025-04-15 21:41:02.579545 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2025-04-15 21:41:02.881508 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2025-04-15 21:41:03.169941 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2025-04-15 21:41:03.462514 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2025-04-15 21:41:03.695131 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2025-04-15 21:41:03.87982 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2025-04-15 21:41:04.086719 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2025-04-15 21:41:04.309848 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2025-04-15 21:41:04.490983 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2025-04-15 21:41:04.690486 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2025-04-15 21:41:04.860978 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2025-04-15 21:41:05.155508 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2025-04-15 21:41:05.455387 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2025-04-15 21:41:05.752154 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2025-04-15 21:41:06.047019 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2025-04-15 21:41:06.345415 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2025-04-15 21:41:06.625807 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2025-04-15 21:41:06.820111 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2025-04-15 21:41:07.002446 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2025-04-15 21:41:07.18476 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2025-04-15 21:41:07.357746 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2025-04-15 21:41:07.562309 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2025-04-15 21:41:07.741022 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2025-04-15 21:41:07.96194 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2025-04-15 21:41:08.137391 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2025-04-15 21:41:08.316391 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2025-04-15 21:41:08.52067 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2025-04-15 21:41:08.698513 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2025-04-15 21:41:08.872337 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2025-04-15 21:41:09.052473 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2025-04-15 21:41:09.245011 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2025-04-15 21:41:09.470885 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2025-04-15 21:41:09.667962 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2025-04-15 21:41:09.894292 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2025-04-15 21:41:10.081484 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2025-04-15 21:41:10.281276 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2025-04-15 21:41:10.485882 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2025-04-15 21:41:10.719964 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2025-04-15 21:41:11.011272 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2025-04-15 21:41:11.304083 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2025-04-15 21:41:11.626986 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2025-04-15 21:41:11.915038 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2025-04-15 21:41:12.202287 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2025-04-15 21:41:12.494188 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2025-04-15 21:41:12.787183 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2025-04-15 21:41:13.086984 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2025-04-15 21:41:13.382054 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2025-04-15 21:41:13.601859 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2025-04-15 21:41:13.778896 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2025-04-15 21:41:13.975497 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2025-04-15 21:41:14.278853 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2025-04-15 21:41:14.544358 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2025-04-15 21:41:14.811174 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2025-04-15 21:41:15.100497 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2025-04-15 21:41:15.34111 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2025-04-15 21:41:15.586436 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2025-04-15 21:41:15.780524 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2025-04-15 21:41:15.956188 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2025-04-15 21:41:16.214437 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2025-04-15 21:41:16.439006 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2025-04-15 21:41:16.647468 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2025-04-15 21:41:16.829503 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2025-04-15 21:41:17.00309 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2025-04-15 21:41:17.179258 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2025-04-15 21:41:17.393849 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2025-04-15 21:41:17.572799 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2025-04-15 21:41:17.810918 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2025-04-15 21:41:18.022298 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2025-04-15 21:41:18.206539 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2025-04-15 21:41:18.412299 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2025-04-15 21:41:18.591247 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2025-04-15 21:41:18.774448 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2025-04-15 21:41:18.956846 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2025-04-15 21:41:19.134241 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2025-04-15 21:41:20.082963 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2025-04-15 21:41:20.261496 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2025-04-15 21:41:20.43518 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2025-04-15 21:41:20.610234 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2025-04-15 21:41:20.787737 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2025-04-15 21:41:20.969586 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2025-04-15 21:41:21.191499 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2025-04-15 21:41:21.394777 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2025-04-15 21:41:21.655769 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2025-04-15 21:41:21.892132 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2025-04-15 21:41:22.189554 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2025-04-15 21:41:22.455575 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2025-04-15 21:41:22.736402 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2025-04-15 21:41:22.981318 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2025-04-15 21:41:23.24483 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2025-04-15 21:41:23.552987 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2025-04-15 21:41:23.870861 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2025-04-15 21:41:24.080671 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2025-04-15 21:41:24.256757 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2025-04-15 21:41:24.475084 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2025-04-15 21:41:24.763003 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2025-04-15 21:41:24.972858 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2025-04-15 21:41:25.141127 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2025-04-15 21:41:25.335031 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2025-04-15 21:41:25.516909 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2025-04-15 21:41:25.700141 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2025-04-15 21:41:25.890686 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2025-04-15 21:41:26.157014 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2025-04-15 21:41:26.371235 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2025-04-15 21:41:26.543565 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2025-04-15 21:41:26.741441 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2025-04-15 21:41:26.991513 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2025-04-15 21:41:27.23378 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2025-04-15 21:41:27.404041 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2025-04-15 21:41:27.59665 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2025-04-15 21:41:27.78572 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2025-04-15 21:41:27.956087 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2025-04-15 21:41:28.124706 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2025-04-15 21:41:28.293527 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2025-04-15 21:41:28.526285 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2025-04-15 21:41:28.782738 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2025-04-15 21:41:29.317569 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2025-04-15 21:41:29.50441 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2025-04-15 21:41:29.691512 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2025-04-15 21:41:29.940936 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2025-04-15 21:41:30.128737 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2025-04-15 21:41:30.304982 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2025-04-15 21:41:30.526589 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2025-04-15 21:41:30.756934 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2025-04-15 21:41:30.943876 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2025-04-15 21:41:31.131544 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2025-04-15 21:41:31.325368 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2025-04-15 21:41:31.506388 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2025-04-15 21:41:31.694737 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2025-04-15 21:41:31.889744 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2025-04-15 21:41:32.069532 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2025-04-15 21:41:32.259358 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2025-04-15 21:41:32.432649 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2025-04-15 21:41:32.607023 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2025-04-15 21:41:32.797114 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2025-04-15 21:41:32.968587 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2025-04-15 21:41:33.152067 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2025-04-15 21:41:33.399552 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2025-04-15 21:41:33.584132 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2025-04-15 21:41:33.794587 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2025-04-15 21:41:33.967018 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2025-04-15 21:41:34.136289 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2025-04-15 21:41:34.317316 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2025-04-15 21:41:34.487676 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2025-04-15 21:41:34.690419 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2025-04-15 21:41:34.857797 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2025-04-15 21:41:35.10648 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2025-04-15 21:41:35.376166 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2025-04-15 21:41:35.570618 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2025-04-15 21:41:35.756036 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2025-04-15 21:41:35.927213 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2025-04-15 21:41:36.096732 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2025-04-15 21:41:36.279132 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2025-04-15 21:41:36.478187 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2025-04-15 21:41:36.658411 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2025-04-15 21:41:36.826707 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2025-04-15 21:41:36.996181 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2025-04-15 21:41:37.171104 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2025-04-15 21:41:37.352666 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2025-04-15 21:41:37.520382 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2025-04-15 21:41:37.687316 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2025-04-15 21:41:37.857321 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2025-04-15 21:41:38.028063 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2025-04-15 21:41:38.208183 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2025-04-15 21:41:38.373238 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2025-04-15 21:41:38.541021 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2025-04-15 21:41:38.709163 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2025-04-15 21:41:38.879535 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2025-04-15 21:41:39.06267 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2025-04-15 21:41:39.268515 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2025-04-15 21:41:39.541653 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2025-04-15 21:41:39.717394 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2025-04-15 21:41:39.915051 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2025-04-15 21:41:40.101578 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2025-04-15 21:41:40.30544 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2025-04-15 21:41:40.528449 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2025-04-15 21:41:40.705568 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2025-04-15 21:41:40.882205 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2025-04-15 21:41:41.106188 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2025-04-15 21:41:41.28055 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2025-04-15 21:41:41.45032 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2025-04-15 21:41:41.618702 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2025-04-15 21:41:41.790978 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2025-04-15 21:41:41.989902 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2025-04-15 21:41:42.16656 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2025-04-15 21:41:42.344816 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2025-04-15 21:41:42.521491 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2025-04-15 21:41:42.692847 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2025-04-15 21:41:42.895322 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2025-04-15 21:41:43.064739 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2025-04-15 21:41:43.237426 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2025-04-15 21:41:43.407643 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2025-04-15 21:41:43.581048 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2025-04-15 21:41:43.777253 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2025-04-15 21:41:43.947318 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2025-04-15 21:41:44.133667 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2025-04-15 21:41:44.303822 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2025-04-15 21:41:44.486667 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2025-04-15 21:41:44.669584 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2025-04-15 21:41:44.838607 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2025-04-15 21:41:45.008606 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2025-04-15 21:41:45.179485 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2025-04-15 21:41:45.36617 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2025-04-15 21:41:45.550009 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2025-04-15 21:41:45.72126 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2025-04-15 21:41:45.892955 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2025-04-15 21:41:46.064601 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2025-04-15 21:41:46.27425 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2025-04-15 21:41:46.469296 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2025-04-15 21:41:46.637342 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2025-04-15 21:41:46.812803 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2025-04-15 21:41:46.986374 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2025-04-15 21:41:47.18603 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2025-04-15 21:41:47.363139 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2025-04-15 21:41:47.604182 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2025-04-15 21:41:47.845994 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2025-04-15 21:41:48.044065 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2025-04-15 21:41:48.302574 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2025-04-15 21:41:48.597803 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2025-04-15 21:41:48.786273 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2025-04-15 21:41:48.98088 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2025-04-15 21:41:49.261865 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2025-04-15 21:41:49.49302 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2025-04-15 21:41:49.782332 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2025-04-15 21:41:49.960412 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2025-04-15 21:41:50.154856 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2025-04-15 21:41:50.414667 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2025-04-15 21:41:50.623496 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2025-04-15 21:41:50.803466 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2025-04-15 21:41:50.984399 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2025-04-15 21:41:51.184226 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2025-04-15 21:41:51.419118 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2025-04-15 21:41:51.762641 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2025-04-15 21:41:52.069947 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2025-04-15 21:41:52.369137 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2025-04-15 21:41:52.664664 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2025-04-15 21:41:52.964226 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2025-04-15 21:41:53.258551 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2025-04-15 21:41:53.526313 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2025-04-15 21:41:53.782038 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2025-04-15 21:41:53.990861 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2025-04-15 21:41:54.265154 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2025-04-15 21:41:54.577674 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2025-04-15 21:41:54.860582 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2025-04-15 21:41:55.116106 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2025-04-15 21:41:55.394745 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2025-04-15 21:41:55.681712 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2025-04-15 21:41:55.919769 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2025-04-15 21:41:56.153279 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2025-04-15 21:41:56.431366 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2025-04-15 21:41:56.73117 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2025-04-15 21:41:57.046086 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2025-04-15 21:41:57.297341 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2025-04-15 21:41:57.488666 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2025-04-15 21:41:57.6967 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2025-04-15 21:41:57.989733 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2025-04-15 21:41:58.322999 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2025-04-15 21:41:58.625028 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2025-04-15 21:41:58.925868 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2025-04-15 21:41:59.222553 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2025-04-15 21:41:59.438793 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2025-04-15 21:41:59.774869 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2025-04-15 21:42:00.069639 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2025-04-15 21:42:00.359687 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2025-04-15 21:42:00.642751 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2025-04-15 21:42:00.929563 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2025-04-15 21:42:01.247384 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2025-04-15 21:42:01.43997 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2025-04-15 21:42:01.633779 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2025-04-15 21:42:01.878508 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2025-04-15 21:42:02.237382 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2025-04-15 21:42:02.532213 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2025-04-15 21:42:02.776056 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2025-04-15 21:42:03.043149 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2025-04-15 21:42:03.239994 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2025-04-15 21:42:03.44916 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2025-04-15 21:42:03.640346 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2025-04-15 21:42:03.810368 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2025-04-15 21:42:03.983893 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2025-04-15 21:42:04.167674 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2025-04-15 21:42:04.523742 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2025-04-15 21:42:04.827958 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2025-04-15 21:42:05.040966 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2025-04-15 21:42:05.299354 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2025-04-15 21:42:05.601099 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2025-04-15 21:42:05.886751 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2025-04-15 21:42:06.139508 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2025-04-15 21:42:06.409367 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2025-04-15 21:42:06.697118 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2025-04-15 21:42:06.919097 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2025-04-15 21:42:07.175328 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2025-04-15 21:42:07.430733 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2025-04-15 21:42:07.618656 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2025-04-15 21:42:07.840832 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2025-04-15 21:42:08.140997 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2025-04-15 21:42:08.413511 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2025-04-15 21:42:08.646126 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2025-04-15 21:42:08.863947 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2025-04-15 21:42:09.117722 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2025-04-15 21:42:09.414369 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2025-04-15 21:42:09.734694 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2025-04-15 21:42:10.044332 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2025-04-15 21:42:10.295526 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2025-04-15 21:42:10.474534 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2025-04-15 21:42:10.675991 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2025-04-15 21:42:10.993407 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2025-04-15 21:42:11.256643 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2025-04-15 21:42:14.147428 INFO::Plotting data for metadata number 2, antibiotics
## 2025-04-15 21:42:14.151927 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2025-04-15 21:42:14.485811 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2025-04-15 21:42:14.838403 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2025-04-15 21:42:15.1667 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2025-04-15 21:42:15.508715 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2025-04-15 21:42:15.800899 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2025-04-15 21:42:16.102255 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2025-04-15 21:42:16.382415 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2025-04-15 21:42:16.654414 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2025-04-15 21:42:16.885465 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2025-04-15 21:42:17.120608 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2025-04-15 21:42:17.31208 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2025-04-15 21:42:17.500631 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2025-04-15 21:42:17.763823 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2025-04-15 21:42:18.044061 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2025-04-15 21:42:18.323739 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2025-04-15 21:42:18.617407 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2025-04-15 21:42:18.969303 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2025-04-15 21:42:19.28401 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2025-04-15 21:42:19.503228 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2025-04-15 21:42:19.802053 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2025-04-15 21:42:20.001204 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2025-04-15 21:42:20.269798 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2025-04-15 21:42:20.509109 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2025-04-15 21:42:20.763571 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2025-04-15 21:42:20.95779 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2025-04-15 21:42:21.314402 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2025-04-15 21:42:21.534495 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2025-04-15 21:42:21.79548 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2025-04-15 21:42:21.988711 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2025-04-15 21:42:22.216957 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2025-04-15 21:42:22.466688 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2025-04-15 21:42:22.725217 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2025-04-15 21:42:22.944523 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2025-04-15 21:42:23.163767 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2025-04-15 21:42:23.403896 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2025-04-15 21:42:23.630807 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2025-04-15 21:42:23.951864 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2025-04-15 21:42:24.288953 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2025-04-15 21:42:24.579629 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2025-04-15 21:42:24.91477 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2025-04-15 21:42:25.164401 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2025-04-15 21:42:25.421472 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2025-04-15 21:42:25.654252 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2025-04-15 21:42:25.977238 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2025-04-15 21:42:26.287632 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2025-04-15 21:42:26.527124 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2025-04-15 21:42:26.802748 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2025-04-15 21:42:27.031459 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2025-04-15 21:42:27.253478 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2025-04-15 21:42:27.457014 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2025-04-15 21:42:27.642912 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2025-04-15 21:42:27.827045 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2025-04-15 21:42:28.112853 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2025-04-15 21:42:28.321951 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2025-04-15 21:42:28.506956 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2025-04-15 21:42:28.780258 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2025-04-15 21:42:29.101106 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2025-04-15 21:42:29.43827 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2025-04-15 21:42:29.752697 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2025-04-15 21:42:30.061915 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2025-04-15 21:42:30.341908 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2025-04-15 21:42:30.709587 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2025-04-15 21:42:30.975241 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2025-04-15 21:42:31.197234 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2025-04-15 21:42:31.413048 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2025-04-15 21:42:31.713867 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2025-04-15 21:42:32.073098 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2025-04-15 21:42:32.363796 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2025-04-15 21:42:32.634635 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2025-04-15 21:42:32.94482 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2025-04-15 21:42:33.288787 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2025-04-15 21:42:33.549312 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2025-04-15 21:42:33.734464 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2025-04-15 21:42:33.917002 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2025-04-15 21:42:34.127187 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2025-04-15 21:42:34.381306 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2025-04-15 21:42:34.656866 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2025-04-15 21:42:34.875231 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2025-04-15 21:42:35.112312 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2025-04-15 21:42:35.423202 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2025-04-15 21:42:35.718038 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2025-04-15 21:42:36.004722 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2025-04-15 21:42:36.280667 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2025-04-15 21:42:36.515804 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2025-04-15 21:42:36.751808 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2025-04-15 21:42:36.968833 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2025-04-15 21:42:37.200029 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2025-04-15 21:42:37.41633 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2025-04-15 21:42:37.616153 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2025-04-15 21:42:37.847988 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2025-04-15 21:42:38.056398 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2025-04-15 21:42:38.260919 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2025-04-15 21:42:38.462206 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2025-04-15 21:42:38.713202 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2025-04-15 21:42:38.995914 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2025-04-15 21:42:39.267281 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2025-04-15 21:42:39.454942 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2025-04-15 21:42:39.641582 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2025-04-15 21:42:39.859342 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2025-04-15 21:42:40.05269 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2025-04-15 21:42:40.341603 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2025-04-15 21:42:40.52905 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2025-04-15 21:42:40.750331 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2025-04-15 21:42:40.943299 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2025-04-15 21:42:41.130924 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2025-04-15 21:42:41.313771 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2025-04-15 21:42:41.500402 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2025-04-15 21:42:41.770809 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2025-04-15 21:42:42.006396 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2025-04-15 21:42:42.200116 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2025-04-15 21:42:42.38455 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2025-04-15 21:42:42.599986 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2025-04-15 21:42:42.898754 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2025-04-15 21:42:43.127451 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2025-04-15 21:42:43.364359 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2025-04-15 21:42:43.588803 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2025-04-15 21:42:43.870436 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2025-04-15 21:42:44.169941 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2025-04-15 21:42:44.388906 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2025-04-15 21:42:44.690196 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2025-04-15 21:42:44.98971 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2025-04-15 21:42:45.320512 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2025-04-15 21:42:45.623318 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2025-04-15 21:42:45.809001 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2025-04-15 21:42:45.996369 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2025-04-15 21:42:46.235309 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2025-04-15 21:42:46.465121 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2025-04-15 21:42:46.679415 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2025-04-15 21:42:46.864166 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2025-04-15 21:42:47.090581 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2025-04-15 21:42:47.350035 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2025-04-15 21:42:47.615522 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2025-04-15 21:42:47.828448 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2025-04-15 21:42:48.05674 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2025-04-15 21:42:48.287978 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2025-04-15 21:42:48.482659 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2025-04-15 21:42:48.670735 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2025-04-15 21:42:48.858569 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2025-04-15 21:42:49.100042 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2025-04-15 21:42:49.291493 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2025-04-15 21:42:49.478868 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2025-04-15 21:42:49.657979 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2025-04-15 21:42:49.868072 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2025-04-15 21:42:50.143307 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2025-04-15 21:42:50.407352 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2025-04-15 21:42:50.603829 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2025-04-15 21:42:50.792926 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2025-04-15 21:42:51.073104 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2025-04-15 21:42:51.270739 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2025-04-15 21:42:51.468327 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2025-04-15 21:42:51.671008 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2025-04-15 21:42:51.914386 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2025-04-15 21:42:52.124842 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2025-04-15 21:42:52.400571 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2025-04-15 21:42:52.652815 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2025-04-15 21:42:52.987766 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2025-04-15 21:42:53.413342 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2025-04-15 21:42:53.632491 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2025-04-15 21:42:53.839995 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2025-04-15 21:42:54.051371 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2025-04-15 21:42:54.305362 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2025-04-15 21:42:54.52224 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2025-04-15 21:42:54.799223 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2025-04-15 21:42:55.09061 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2025-04-15 21:42:55.33647 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2025-04-15 21:42:55.555147 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2025-04-15 21:42:55.770355 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2025-04-15 21:42:56.000509 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2025-04-15 21:42:56.309177 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2025-04-15 21:42:56.571309 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2025-04-15 21:42:56.764512 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2025-04-15 21:42:56.956952 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2025-04-15 21:42:57.150436 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2025-04-15 21:42:57.358145 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2025-04-15 21:42:57.647915 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2025-04-15 21:42:57.87919 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2025-04-15 21:42:58.084549 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2025-04-15 21:42:58.340195 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2025-04-15 21:42:58.655112 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2025-04-15 21:42:58.991952 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2025-04-15 21:42:59.294008 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2025-04-15 21:42:59.486965 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2025-04-15 21:42:59.694018 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2025-04-15 21:42:59.90752 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2025-04-15 21:43:00.139119 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2025-04-15 21:43:00.401523 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2025-04-15 21:43:00.645621 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2025-04-15 21:43:00.963196 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2025-04-15 21:43:01.322326 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2025-04-15 21:43:01.613156 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2025-04-15 21:43:01.817492 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2025-04-15 21:43:02.084627 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2025-04-15 21:43:02.42477 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2025-04-15 21:43:02.686458 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2025-04-15 21:43:02.935959 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2025-04-15 21:43:03.237714 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2025-04-15 21:43:03.441745 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2025-04-15 21:43:03.664478 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2025-04-15 21:43:03.87007 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2025-04-15 21:43:04.073054 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2025-04-15 21:43:04.266688 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2025-04-15 21:43:04.485156 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2025-04-15 21:43:04.78289 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2025-04-15 21:43:05.086247 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2025-04-15 21:43:05.404527 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2025-04-15 21:43:05.724938 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2025-04-15 21:43:06.003384 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2025-04-15 21:43:06.285888 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2025-04-15 21:43:06.597237 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2025-04-15 21:43:06.85019 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2025-04-15 21:43:07.166237 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2025-04-15 21:43:07.461405 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2025-04-15 21:43:07.799287 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2025-04-15 21:43:08.115454 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2025-04-15 21:43:08.338442 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2025-04-15 21:43:08.705256 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2025-04-15 21:43:09.058649 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2025-04-15 21:43:09.273864 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2025-04-15 21:43:09.512052 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2025-04-15 21:43:09.790895 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2025-04-15 21:43:10.130232 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2025-04-15 21:43:10.353825 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2025-04-15 21:43:10.640364 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2025-04-15 21:43:10.943219 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2025-04-15 21:43:11.228028 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2025-04-15 21:43:11.477179 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2025-04-15 21:43:11.76272 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2025-04-15 21:43:12.023033 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2025-04-15 21:43:12.296599 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2025-04-15 21:43:12.546536 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2025-04-15 21:43:12.830729 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2025-04-15 21:43:13.06078 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2025-04-15 21:43:13.303534 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2025-04-15 21:43:13.586721 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2025-04-15 21:43:13.89296 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2025-04-15 21:43:14.195309 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2025-04-15 21:43:14.498734 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2025-04-15 21:43:14.729001 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2025-04-15 21:43:14.979854 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2025-04-15 21:43:15.232633 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2025-04-15 21:43:15.423349 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2025-04-15 21:43:15.641072 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2025-04-15 21:43:15.840425 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2025-04-15 21:43:16.040342 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2025-04-15 21:43:16.235242 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2025-04-15 21:43:16.424594 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2025-04-15 21:43:16.649584 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2025-04-15 21:43:16.851589 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2025-04-15 21:43:17.064341 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2025-04-15 21:43:17.304785 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2025-04-15 21:43:17.569226 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2025-04-15 21:43:17.783366 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2025-04-15 21:43:18.114757 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2025-04-15 21:43:18.439914 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2025-04-15 21:43:18.759713 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2025-04-15 21:43:19.114332 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2025-04-15 21:43:19.356782 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2025-04-15 21:43:19.553876 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2025-04-15 21:43:19.806457 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2025-04-15 21:43:20.103167 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2025-04-15 21:43:20.398732 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2025-04-15 21:43:20.659631 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2025-04-15 21:43:20.923601 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2025-04-15 21:43:21.155206 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2025-04-15 21:43:21.41378 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2025-04-15 21:43:21.628668 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2025-04-15 21:43:21.832677 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2025-04-15 21:43:22.064838 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2025-04-15 21:43:22.337151 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2025-04-15 21:43:22.661358 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2025-04-15 21:43:22.898036 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2025-04-15 21:43:23.187748 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2025-04-15 21:43:23.39017 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2025-04-15 21:43:23.644054 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2025-04-15 21:43:23.860866 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2025-04-15 21:43:24.065909 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2025-04-15 21:43:24.272354 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2025-04-15 21:43:24.587355 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2025-04-15 21:43:24.955202 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2025-04-15 21:43:25.170862 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2025-04-15 21:43:25.463361 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2025-04-15 21:43:25.735591 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2025-04-15 21:43:26.046556 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2025-04-15 21:43:26.329642 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2025-04-15 21:43:26.618945 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2025-04-15 21:43:26.904745 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2025-04-15 21:43:27.149463 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2025-04-15 21:43:27.408455 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2025-04-15 21:43:27.604929 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2025-04-15 21:43:27.804434 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2025-04-15 21:43:27.995259 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2025-04-15 21:43:28.225769 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2025-04-15 21:43:28.423806 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2025-04-15 21:43:28.620285 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2025-04-15 21:43:28.859902 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2025-04-15 21:43:29.048816 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2025-04-15 21:43:29.303405 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2025-04-15 21:43:29.52645 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2025-04-15 21:43:29.755563 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2025-04-15 21:43:29.944486 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2025-04-15 21:43:30.170211 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2025-04-15 21:43:30.368993 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2025-04-15 21:43:30.560881 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2025-04-15 21:43:30.754772 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2025-04-15 21:43:30.93991 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2025-04-15 21:43:31.163845 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2025-04-15 21:43:31.35601 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2025-04-15 21:43:31.549125 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2025-04-15 21:43:31.74232 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2025-04-15 21:43:31.986279 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2025-04-15 21:43:32.187851 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2025-04-15 21:43:32.380189 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2025-04-15 21:43:32.600778 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2025-04-15 21:43:32.885832 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2025-04-15 21:43:33.150854 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2025-04-15 21:43:33.353904 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2025-04-15 21:43:33.546897 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2025-04-15 21:43:33.857939 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2025-04-15 21:43:34.10902 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2025-04-15 21:43:34.31888 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2025-04-15 21:43:34.521309 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2025-04-15 21:43:34.712438 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2025-04-15 21:43:34.907664 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2025-04-15 21:43:35.138449 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2025-04-15 21:43:35.370918 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2025-04-15 21:43:35.570278 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2025-04-15 21:43:35.764684 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2025-04-15 21:43:35.995739 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2025-04-15 21:43:36.194845 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2025-04-15 21:43:36.407753 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2025-04-15 21:43:36.605025 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2025-04-15 21:43:36.825803 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2025-04-15 21:43:37.039971 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2025-04-15 21:43:37.231031 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2025-04-15 21:43:37.431143 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2025-04-15 21:43:37.6506 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2025-04-15 21:43:37.931708 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2025-04-15 21:43:38.142526 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2025-04-15 21:43:38.339226 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2025-04-15 21:43:38.532353 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2025-04-15 21:43:38.764132 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2025-04-15 21:43:38.958584 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2025-04-15 21:43:39.155337 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2025-04-15 21:43:39.349188 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2025-04-15 21:43:39.538454 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2025-04-15 21:43:40.758768 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2025-04-15 21:43:41.020744 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2025-04-15 21:43:41.26128 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2025-04-15 21:43:41.539358 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2025-04-15 21:43:41.78724 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2025-04-15 21:43:42.065369 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2025-04-15 21:43:42.350919 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2025-04-15 21:43:42.621439 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2025-04-15 21:43:42.858238 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2025-04-15 21:43:43.047246 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2025-04-15 21:43:43.238184 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2025-04-15 21:43:43.427036 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2025-04-15 21:43:43.62582 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2025-04-15 21:43:43.82208 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2025-04-15 21:43:44.04943 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2025-04-15 21:43:44.246508 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2025-04-15 21:43:44.455024 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2025-04-15 21:43:44.654375 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2025-04-15 21:43:44.890094 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2025-04-15 21:43:45.157254 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2025-04-15 21:43:45.415347 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2025-04-15 21:43:45.629609 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2025-04-15 21:43:45.834614 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2025-04-15 21:43:46.036465 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2025-04-15 21:43:46.235676 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2025-04-15 21:43:46.441478 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2025-04-15 21:43:46.635104 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2025-04-15 21:43:46.827182 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2025-04-15 21:43:47.025469 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2025-04-15 21:43:47.212961 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2025-04-15 21:43:47.407168 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2025-04-15 21:43:47.596468 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2025-04-15 21:43:47.801139 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2025-04-15 21:43:47.990014 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2025-04-15 21:43:48.178104 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2025-04-15 21:43:48.373141 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2025-04-15 21:43:48.633609 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2025-04-15 21:43:48.929944 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2025-04-15 21:43:49.164991 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2025-04-15 21:43:49.355762 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2025-04-15 21:43:49.545709 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2025-04-15 21:43:49.75413 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2025-04-15 21:43:49.942106 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2025-04-15 21:43:50.128518 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2025-04-15 21:43:50.347035 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2025-04-15 21:43:50.626003 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2025-04-15 21:43:50.90493 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2025-04-15 21:43:51.146369 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2025-04-15 21:43:51.446856 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2025-04-15 21:43:51.734064 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2025-04-15 21:43:52.02453 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2025-04-15 21:43:52.335211 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2025-04-15 21:43:52.622272 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2025-04-15 21:43:52.90682 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2025-04-15 21:43:53.166021 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2025-04-15 21:43:53.445882 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2025-04-15 21:43:53.710866 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2025-04-15 21:43:53.967647 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2025-04-15 21:43:54.21995 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2025-04-15 21:43:54.409118 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2025-04-15 21:43:54.68026 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2025-04-15 21:43:54.979329 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2025-04-15 21:43:55.264699 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2025-04-15 21:43:55.489302 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2025-04-15 21:43:55.711395 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2025-04-15 21:43:55.895302 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2025-04-15 21:43:56.127891 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2025-04-15 21:43:56.303639 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2025-04-15 21:43:56.483955 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2025-04-15 21:43:56.671791 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2025-04-15 21:43:56.846937 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2025-04-15 21:43:57.024768 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2025-04-15 21:43:57.215462 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2025-04-15 21:43:57.450424 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2025-04-15 21:43:57.644779 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2025-04-15 21:43:57.868977 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2025-04-15 21:43:58.111281 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2025-04-15 21:43:58.292135 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2025-04-15 21:43:58.504477 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2025-04-15 21:43:58.689475 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2025-04-15 21:43:58.871484 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2025-04-15 21:43:59.065964 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2025-04-15 21:43:59.27173 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2025-04-15 21:43:59.516714 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2025-04-15 21:43:59.811791 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2025-04-15 21:44:00.111267 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2025-04-15 21:44:00.405806 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2025-04-15 21:44:00.717424 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2025-04-15 21:44:00.989748 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2025-04-15 21:44:01.300718 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2025-04-15 21:44:01.584506 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2025-04-15 21:44:04.351892 INFO::Plotting data for metadata number 3, age
## 2025-04-15 21:44:04.355984 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:04.789921 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:05.187848 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:05.438334 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:05.661082 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:05.918476 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:06.242052 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:06.435504 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:06.638971 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:06.856043 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:07.070806 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:07.332033 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:07.60975 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:07.910397 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:08.100794 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:08.292208 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:08.488784 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:08.740773 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:09.073129 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:09.392851 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:09.632455 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:09.83925 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:10.126225 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:10.344527 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:10.675886 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:11.004372 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:11.31464 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:11.50978 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:11.713262 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:11.996434 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:12.267801 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:12.446698 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:12.644749 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:12.895658 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:13.105929 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:13.293386 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:13.482834 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:13.687158 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:13.885983 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:14.067277 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:14.279368 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:14.52522 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:14.827241 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:15.02786 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:15.215225 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:15.419252 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:15.684262 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:15.887578 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:16.129214 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:16.338628 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:16.550141 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:16.737682 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:16.93217 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:17.126279 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:17.368608 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:17.565908 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:17.785888 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:17.980542 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:18.272137 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:18.554342 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:18.788244 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:19.064812 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:19.357244 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:19.542705 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:19.733817 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:19.908882 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:20.127892 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:20.324513 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:20.543825 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:20.729981 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:21.060602 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:21.342429 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:21.557233 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:21.759831 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:21.981527 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:22.160326 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:22.366866 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:22.56366 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:22.777968 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:22.964257 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:23.139054 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:23.331085 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:23.631035 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:23.923062 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:24.152691 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:24.373854 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:24.676357 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:24.992201 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:25.203089 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:25.475102 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:25.781329 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:26.037804 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:26.270859 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:26.508351 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:26.709495 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:26.936938 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:27.192648 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:27.421798 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:27.678028 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:27.960067 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:28.147648 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:28.360169 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:28.551145 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:28.762246 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:29.101882 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:29.341972 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:29.540976 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:29.885351 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:30.181436 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:30.514069 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:30.714234 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:30.936273 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:31.164046 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:31.437405 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:31.699058 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:31.963368 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:32.253714 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:32.530356 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:32.787357 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:33.072302 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:33.377973 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:33.642929 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:33.863675 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:34.071026 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:34.303731 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:34.605335 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:34.888056 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:35.110414 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:35.346514 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:35.64575 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:35.960615 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:36.175118 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:36.521649 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:36.737428 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:36.981869 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:37.289336 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:37.550062 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:37.803468 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:38.093951 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:38.397768 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:38.681968 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:38.956308 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:39.196179 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:39.473749 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:39.765355 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:40.028294 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:40.275247 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:40.512687 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:40.78762 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:41.057573 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:41.380928 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:41.673767 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:41.928149 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:42.166083 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:42.503936 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:42.741148 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:43.000123 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:43.22718 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:43.468111 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:43.738729 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:43.977756 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2025-04-15 21:44:44.165282 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:44.394179 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-04-15 21:44:44.704167 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
##
## Calculating mean abundance in: IBD
##
## Calculating mean abundance in: Control
##
## Calculating effect size in: IBD
##
## Initiating prioritization
##
## Calculating meta-rank and prioritizing metabolic features
## 2025-04-15 21:44:48.014837 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2025-04-15 21:44:48.04585 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2025-04-15 21:44:48.08216 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv
abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames
taxonomy_df = read.csv(file = mets_taxonomy)
# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df)
The Macarron::Macarron()
function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:
# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df)
# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)
# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]
# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
mod.assn = prism_modules)
# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules)
# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
mac.qval = prism_qval)
# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
mod.assn = prism_modules,
mac.ava = prism_ava,
mac.qval = prism_qval,
mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]
# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)
Session info from running the demo in R can be displayed with the following command.
sessionInfo()
## R version 4.5.0 RC (2025-04-04 r88126 ucrt)
## Platform: x86_64-w64-mingw32/x64
## Running under: Windows Server 2022 x64 (build 20348)
##
## Matrix products: default
## LAPACK version 3.12.1
##
## locale:
## [1] LC_COLLATE=C
## [2] LC_CTYPE=English_United States.utf8
## [3] LC_MONETARY=English_United States.utf8
## [4] LC_NUMERIC=C
## [5] LC_TIME=English_United States.utf8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] Macarron_1.12.0 SummarizedExperiment_1.38.0
## [3] Biobase_2.68.0 GenomicRanges_1.60.0
## [5] GenomeInfoDb_1.44.0 IRanges_2.42.0
## [7] S4Vectors_0.46.0 BiocGenerics_0.54.0
## [9] generics_0.1.3 MatrixGenerics_1.20.0
## [11] matrixStats_1.5.0 BiocStyle_2.36.0
##
## loaded via a namespace (and not attached):
## [1] mnormt_2.1.1 DBI_1.2.3 pbapply_1.7-2
## [4] gridExtra_2.3 rlang_1.1.6 magrittr_2.0.3
## [7] compiler_4.5.0 RSQLite_2.3.9 mgcv_1.9-3
## [10] png_0.1-8 vctrs_0.6.5 stringr_1.5.1
## [13] pkgconfig_2.0.3 crayon_1.5.3 fastmap_1.2.0
## [16] backports_1.5.0 XVector_0.48.0 labeling_0.4.3
## [19] rmarkdown_2.29 UCSC.utils_1.4.0 preprocessCore_1.70.0
## [22] bit_4.6.0 xfun_0.52 cachem_1.1.0
## [25] jsonlite_2.0.0 blob_1.2.4 DelayedArray_0.34.0
## [28] BiocParallel_1.42.0 psych_2.5.3 Maaslin2_1.22.0
## [31] parallel_4.5.0 cluster_2.1.8.1 biglm_0.9-3
## [34] R6_2.6.1 RColorBrewer_1.1-3 bslib_0.9.0
## [37] stringi_1.8.7 rpart_4.1.24 jquerylib_0.1.4
## [40] Rcpp_1.0.14 bookdown_0.43 iterators_1.0.14
## [43] knitr_1.50 WGCNA_1.73 base64enc_0.1-3
## [46] Matrix_1.7-3 splines_4.5.0 nnet_7.3-20
## [49] tidyselect_1.2.1 rstudioapi_0.17.1 abind_1.4-8
## [52] yaml_2.3.10 doParallel_1.0.17 codetools_0.2-20
## [55] plyr_1.8.9 lattice_0.22-7 tibble_3.2.1
## [58] withr_3.0.2 KEGGREST_1.48.0 evaluate_1.0.3
## [61] foreign_0.8-90 survival_3.8-3 getopt_1.20.4
## [64] Biostrings_2.76.0 pillar_1.10.2 BiocManager_1.30.25
## [67] checkmate_2.3.2 foreach_1.5.2 pcaPP_2.0-5
## [70] ggplot2_3.5.2 munsell_0.5.1 scales_1.3.0
## [73] glue_1.8.0 Hmisc_5.2-3 tools_4.5.0
## [76] robustbase_0.99-4-1 data.table_1.17.0 mvtnorm_1.3-3
## [79] fastcluster_1.2.6 grid_4.5.0 optparse_1.7.5
## [82] impute_1.82.0 AnnotationDbi_1.70.0 colorspace_2.1-1
## [85] nlme_3.1-168 GenomeInfoDbData_1.2.14 htmlTable_2.4.3
## [88] Formula_1.2-5 cli_3.6.4 S4Arrays_1.8.0
## [91] dplyr_1.1.4 DEoptimR_1.1-3-1 gtable_0.3.6
## [94] hash_2.2.6.3 logging_0.10-108 dynamicTreeCut_1.63-1
## [97] sass_0.4.10 digest_0.6.37 SparseArray_1.8.0
## [100] farver_2.1.2 htmlwidgets_1.6.4 memoise_2.0.1
## [103] htmltools_0.5.8.1 lifecycle_1.0.4 httr_1.4.7
## [106] GO.db_3.21.0 bit64_4.6.0-1
The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID()
. This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.
taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)
A record of all chosen parameters and steps that were followed during execution.
This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size
) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:
This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.
Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence
argument.
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df,
min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
min_prevalence = 0.5)
By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size
) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA
and dynamicTreeCut
.
# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)
# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df,
min_module_size = 10)
Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable
argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories.
Defaults can be changed with the arguments fixed_effects
, random_effects
and reference
. In the demo example, fixed effects
and reference
can be defined as follows:
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules,
metadata_variable = "diagnosis",
fixed_effects = c("diagnosis","age","antibiotics"),
reference = c("diagnosis,Control";"antibiotics,No"))
The package source contains a script MacarronCMD.R
in inst/scripts
to invoke Macarron in the command line using Rscript.
The inst/scripts
folder also contains a README file that comprehensively documents the usage of the script.