Alan Williams, Director, Chip Design
Earl Hubbell, Principal Statistician
Chuck Sugnet, Staff Bioinformatics Scientist
Harley Gorrell, Staff Software Engineer

Ongoing technology developments have enabled the tiling of over 6 million probes on a single Affymetrix oligo microarray. This technology push has enabled the development of commercial whole genome exon and tiling arrays. Current exon microarray implementations consist of a single microarray covering roughly 1 million exons with 1.4 million probesets consisting of 4 perfect match probes per probeset; tiling array implementations consist of tiling either a perfect match probe (for 7 chip set) or a perfect match and mismatch probe (for 14 chip set) every 35 bases across the entire genome. These product concepts are being applied for human and mouse with other organisms to follow.

Fred Hutchinson Cancer Research Center