anota

ANalysis Of Translational Activity (ANOTA).

Bioconductor version: Release (2.14)

Genome wide studies of translational control is emerging as a tool to study verious biological conditions. The output from such analysis is both the mRNA level (e.g. cytosolic mRNA level) and the levl of mRNA actively involved in translation (the actively translating mRNA level) for each mRNA. The standard analysis of such data strives towards identifying differential translational between two or more sample classes - i.e. differences in actively translated mRNA levels that are independent of underlying differences in cytosolic mRNA levels. This package allows for such analysis using partial variances and the random variance model. As 10s of thousands of mRNAs are analyzed in parallell the library performs a number of tests to assure that the data set is suitable for such analysis.

Author: Ola Larsson <ola.larsson at ki.se>, Nahum Sonenberg <nahum.sonenberg at mcgill.ca>, Robert Nadon <robert.nadon at mcgill.ca>

Maintainer: Ola Larsson <ola.larsson at ki.se>

To install this package, start R and enter:

    source("http://bioconductor.org/biocLite.R")
    biocLite("anota")

To cite this package in a publication, start R and enter:

    citation("anota")

Documentation

PDF R Script ANalysis Of Translational Activity (anota)
PDF   Reference Manual
Text   NEWS

Details

biocViews DifferentialExpression, GeneExpression, Microarray, Sequencing, Software
Version 1.12.0
In Bioconductor since BioC 2.8 (R-2.13)
License GPL-3
Depends qvalue
Imports multtest, qvalue
Suggests
System Requirements
URL
Depends On Me tRanslatome
Imports Me
Suggests Me

Package Downloads

Package Source anota_1.12.0.tar.gz
Windows Binary anota_1.12.0.zip (32- & 64-bit)
Mac OS X 10.6 (Snow Leopard) anota_1.12.0.tgz
Mac OS X 10.9 (Mavericks)
Package Downloads Report Download Stats

Mailing Lists »

Post questions about Bioconductor packages to our mailing lists. Read the posting guide before posting!

Fred Hutchinson Cancer Research Center