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This is the development version of EpiDISH; for the stable release version, see EpiDISH.

Epigenetic Dissection of Intra-Sample-Heterogeneity

Bioconductor version: Development (3.20)

EpiDISH is a R package to infer the proportions of a priori known cell-types present in a sample representing a mixture of such cell-types. Right now, the package can be used on DNAm data of whole blood, generic epithelial tissue and breast tissue. Besides, the package provides a function that allows the identification of differentially methylated cell-types and their directionality of change in Epigenome-Wide Association Studies.

Author: Andrew E. Teschendorff [aut], Shijie C. Zheng [aut, cre]

Maintainer: Shijie C. Zheng <shijieczheng at>

Citation (from within R, enter citation("EpiDISH")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Epigenetic Dissection of Intra-Sample-Heterogeneity HTML R Script
Reference Manual PDF


biocViews DNAMethylation, DifferentialMethylation, Epigenetics, ImmunoOncology, MethylationArray, Software
Version 2.21.1
In Bioconductor since BioC 3.6 (R-3.4) (6.5 years)
License GPL-2
Depends R (>= 4.1)
Imports MASS, e1071, quadprog, parallel, stats, matrixStats, stringr, locfdr, Matrix
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Suggests roxygen2, GEOquery, BiocStyle, knitr, rmarkdown, Biobase, testthat
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Follow Installation instructions to use this package in your R session.

Source Package EpiDISH_2.21.1.tar.gz
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macOS Binary (x86_64) EpiDISH_2.21.1.tgz
macOS Binary (arm64) EpiDISH_2.21.1.tgz
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Source Repository (Developer Access) git clone
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