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This is the development version of Rtpca; for the stable release version, see Rtpca.

Thermal proximity co-aggregation with R

Bioconductor version: Development (3.20)

R package for performing thermal proximity co-aggregation analysis with thermal proteome profiling datasets to analyse protein complex assembly and (differential) protein-protein interactions across conditions.

Author: Nils Kurzawa [aut, cre], André Mateus [aut], Mikhail M. Savitski [aut]

Maintainer: Nils Kurzawa <nilskurzawa at>

Citation (from within R, enter citation("Rtpca")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Introduction to Rtpca HTML R Script
Reference Manual PDF


biocViews DataImport, Proteomics, Software
Version 1.15.0
In Bioconductor since BioC 3.12 (R-4.0) (3.5 years)
License GPL-3
Depends R (>= 4.0.0), stats, dplyr, tidyr
Imports Biobase, methods, ggplot2, pROC, fdrtool, splines, utils, tibble
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Suggests knitr, BiocStyle, TPP, testthat, rmarkdown
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Follow Installation instructions to use this package in your R session.

Source Package Rtpca_1.15.0.tar.gz
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macOS Binary (x86_64) Rtpca_1.15.0.tgz
macOS Binary (arm64) Rtpca_1.15.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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