Registration Open for Bioc2024 July 24-26


This is the development version of globaltest; for the stable release version, see globaltest.

Testing Groups of Covariates/Features for Association with a Response Variable, with Applications to Gene Set Testing

Bioconductor version: Development (3.20)

The global test tests groups of covariates (or features) for association with a response variable. This package implements the test with diagnostic plots and multiple testing utilities, along with several functions to facilitate the use of this test for gene set testing of GO and KEGG terms.

Author: Jelle Goeman and Jan Oosting, with contributions by Livio Finos, Aldo Solari, Dominic Edelmann

Maintainer: Jelle Goeman <j.j.goeman at>

Citation (from within R, enter citation("globaltest")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Global Test PDF R Script
Reference Manual PDF


biocViews Bioinformatics, DifferentialExpression, GO, Microarray, OneChannel, Pathways, Software
Version 5.59.0
In Bioconductor since BioC 1.6 (R-2.1) or earlier (> 19 years)
License GPL (>= 2)
Depends methods, survival
Imports Biobase, AnnotationDbi, annotate, graphics
System Requirements
See More
Suggests vsn, golubEsets, KEGGREST, hu6800.db, Rgraphviz, GO.db, lungExpression,, GSEABase, penalized, gss, MASS, boot, rpart, mstate
Linking To
Depends On Me GlobalAncova
Imports Me BiSeq, EGSEA, SIM, miRtest, SlaPMEG
Suggests Me topGO, penalized
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package globaltest_5.59.0.tar.gz
Windows Binary
macOS Binary (x86_64) globaltest_5.59.0.tgz
macOS Binary (arm64)
Source Repository git clone
Source Repository (Developer Access) git clone
Bioc Package Browser
Package Short Url
Package Downloads Report Download Stats