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This is the development version of regioneReloaded; for the stable release version, see regioneReloaded.

RegioneReloaded: Multiple Association for Genomic Region Sets

Bioconductor version: Development (3.20)

RegioneReloaded is a package that allows simultaneous analysis of associations between genomic region sets, enabling clustering of data and the creation of ready-to-publish graphs. It takes over and expands on all the features of its predecessor regioneR. It also incorporates a strategy to improve p-value calculations and normalize z-scores coming from multiple analysis to allow for their direct comparison. RegioneReloaded builds upon regioneR by adding new plotting functions for obtaining publication-ready graphs.

Author: Roberto Malinverni [aut, cre] , David Corujo [aut], Bernat Gel [aut]

Maintainer: Roberto Malinverni <roberto.malinverni at>

Citation (from within R, enter citation("regioneReloaded")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

regioneReloaded HTML R Script
Reference Manual PDF


biocViews ChIPSeq, Clustering, CopyNumberVariation, DNASeq, Genetics, MethylSeq, MultipleComparison, Software
Version 1.7.0
In Bioconductor since BioC 3.16 (R-4.2) (1.5 years)
License Artistic-2.0
Depends R (>= 4.2), regioneR
Imports stats, RColorBrewer, Rtsne, umap, ggplot2, ggrepel, reshape2, methods, scales, cluster, grid, grDevices
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Suggests rmarkdown, BiocStyle, GenomeInfoDb, knitr, testthat (>= 3.0.0)
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Follow Installation instructions to use this package in your R session.

Source Package regioneReloaded_1.7.0.tar.gz
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macOS Binary (x86_64) regioneReloaded_1.7.0.tgz
macOS Binary (arm64) regioneReloaded_1.7.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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