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This is the development version of simPIC; for the stable release version, see simPIC.

simPIC: flexible simulation of paired-insertion counts for single-cell ATAC-sequencing data

Bioconductor version: Development (3.20)

simPIC is a package for simulating single-cell ATAC-seq count data. It provides a user-friendly, well documented interface for data simulation. Functions are provided for parameter estimation, realistic scATAC-seq data simulation, and comparing real and simulated datasets.

Author: Sagrika Chugh [aut, cre] , Davis McCarthy [aut], Heejung Shim [aut]

Maintainer: Sagrika Chugh <sagrika.chugh at>

Citation (from within R, enter citation("simPIC")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

simPIC: simulating single-cell ATAC-seq data HTML R Script
Reference Manual PDF


biocViews ATACSeq, DataImport, ImmunoOncology, Sequencing, SingleCell, Software
Version 1.1.0
In Bioconductor since BioC 3.19 (R-4.4) (< 6 months)
License GPL-3
Depends R (>= 4.4.0), SingleCellExperiment
Imports BiocGenerics, checkmate (>= 2.0.0), fitdistrplus, matrixStats, Matrix, stats, SummarizedExperiment, actuar, rlang, S4Vectors, methods, scales, scuttle
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Suggests ggplot2 (>= 3.4.0), knitr, rmarkdown, BiocStyle, testthat (>= 3.0.0)
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Follow Installation instructions to use this package in your R session.

Source Package simPIC_1.1.0.tar.gz
Windows Binary
macOS Binary (x86_64) simPIC_1.1.0.tgz
macOS Binary (arm64) simPIC_1.1.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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