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This is the development version of synlet; for the stable release version, see synlet.

Hits Selection for Synthetic Lethal RNAi Screen Data

Bioconductor version: Development (3.20)

Select hits from synthetic lethal RNAi screen data. For example, there are two identical celllines except one gene is knocked-down in one cellline. The interest is to find genes that lead to stronger lethal effect when they are knocked-down further by siRNA. Quality control and various visualisation tools are implemented. Four different algorithms could be used to pick up the interesting hits. This package is designed based on 384 wells plates, but may apply to other platforms with proper configuration.

Author: Chunxuan Shao [aut, cre]

Maintainer: Chunxuan Shao <chunxuan at>

Citation (from within R, enter citation("synlet")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


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A working Demo for synlet HTML R Script
Reference Manual PDF


biocViews CellBasedAssays, FeatureExtraction, ImmunoOncology, Preprocessing, QualityControl, Software, Visualization
Version 2.5.0
In Bioconductor since BioC 3.2 (R-3.2) (8.5 years)
License GPL-3
Depends R (>= 3.5.0)
Imports data.table, ggplot2, grDevices, magrittr, methods, patchwork, RankProd, RColorBrewer, stats, utils
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