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This is the development version of variants; for the stable release version, see variants.

Annotating Genomic Variants

Bioconductor version: Development (3.20)

Read and write VCF files. Identify structural location of variants and compute amino acid coding changes for non-synonymous variants. Use SIFT and PolyPhen database packages to predict consequence of amino acid coding changes.

Author: Valerie Obenchain [aut], Martin Morgan [ctb], Bioconductor Package Maintainer [cre]

Maintainer: Bioconductor Package Maintainer <maintainer at>

Citation (from within R, enter citation("variants")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Annotating Genomic Variants HTML R Script


biocViews AnnotationWorkflow, ImmunoOncologyWorkflow, Workflow
Version 1.29.0
License Artistic-2.0
Depends R (>= 3.3.0), VariantAnnotation,, TxDb.Hsapiens.UCSC.hg19.knownGene, BSgenome.Hsapiens.UCSC.hg19, PolyPhen.Hsapiens.dbSNP131
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Follow Installation instructions to use this package in your R session.

Source Package variants_1.29.0.tar.gz
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