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A Tool for Optimizing Combinations of DNA Barcodes Used in Multiplexed Experiments on Next Generation Sequencing Platforms

Bioconductor version: Release (3.19)

The package allows one to obtain optimised combinations of DNA barcodes to be used for multiplex sequencing. In each barcode combination, barcodes are pooled with respect to Illumina chemistry constraints. Combinations can be filtered to keep those that are robust against substitution and insertion/deletion errors thereby facilitating the demultiplexing step. In addition, the package provides an optimiser function to further favor the selection of barcode combinations with least heterogeneity in barcode usage.

Author: Céline Trébeau [cre] , Jacques Boutet de Monvel [aut] , Fabienne Wong Jun Tai [ctb], Raphaël Etournay [aut]

Maintainer: Céline Trébeau <ctrebeau at>

Citation (from within R, enter citation("DNABarcodeCompatibility")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Introduction to DNABarcodeCompatibility HTML R Script
Reference Manual PDF


biocViews Preprocessing, Sequencing, Software
Version 1.20.0
In Bioconductor since BioC 3.9 (R-3.6) (5 years)
License file LICENSE
Depends R (>= 3.6.0)
Imports dplyr, tidyr, numbers, purrr, stringr, DNABarcodes, stats, utils, methods
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Suggests knitr, rmarkdown, BiocStyle, testthat
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Follow Installation instructions to use this package in your R session.

Source Package DNABarcodeCompatibility_1.20.0.tar.gz
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macOS Binary (x86_64) DNABarcodeCompatibility_1.20.0.tgz
macOS Binary (arm64) DNABarcodeCompatibility_1.20.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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