DOI: 10.18129/B9.bioc.RUVSeq    

This is the development version of RUVSeq; for the stable release version, see RUVSeq.

Remove Unwanted Variation from RNA-Seq Data

Bioconductor version: Development (3.9)

This package implements the remove unwanted variation (RUV) methods of Risso et al. (2014) for the normalization of RNA-Seq read counts between samples.

Author: Davide Risso [aut, cre, cph], Sandrine Dudoit [aut], Lorena Pantano [ctb], Kamil Slowikowski [ctb]

Maintainer: Davide Risso <risso.davide at>

Citation (from within R, enter citation("RUVSeq")):


To install this package, start R (version "3.6") and enter:

if (!requireNamespace("BiocManager", quietly = TRUE))
BiocManager::install("RUVSeq", version = "3.9")

For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:



PDF R Script RUVSeq: Remove Unwanted Variation from RNA-Seq Data
PDF   Reference Manual
Text   NEWS


biocViews DifferentialExpression, ImmunoOncology, Preprocessing, RNASeq, Software
Version 1.17.1
In Bioconductor since BioC 3.0 (R-3.1) (4.5 years)
License Artistic-2.0
Depends Biobase, EDASeq(>= 1.99.1), edgeR
Imports methods, MASS
Suggests BiocStyle, knitr, RColorBrewer, zebrafishRNASeq, DESeq2
Depends On Me rnaseqGene
Imports Me consensusDE, scone
Suggests Me DEScan2
Links To Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package RUVSeq_1.17.1.tar.gz
Windows Binary (32- & 64-bit)
Mac OS X 10.11 (El Capitan) RUVSeq_1.17.1.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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