DOI: 10.18129/B9.bioc.nipalsMCIA  

Multiple Co-Inertia Analysis via the NIPALS Method

Bioconductor version: Release (3.18)

Computes Multiple Co-Inertia Analysis (MCIA), a dimensionality reduction (jDR) algorithm, for a multi-block dataset using a modification to the Nonlinear Iterative Partial Least Squares method (NIPALS) proposed in (Hanafi et. al, 2010). Allows multiple options for row- and table-level preprocessing, and speeds up computation of variance explained. Vignettes detail application to bulk- and single cell- multi-omics studies.

Author: Maximilian Mattessich [cre] , Joaquin Reyna [aut] , Edel Aron [aut] , Anna Konstorum [aut]

Maintainer: Maximilian Mattessich <maximilian.mattessich at>

Citation (from within R, enter citation("nipalsMCIA")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:



HTML R Script Analysis of MCIA Decomposition
HTML R Script Predicting New MCIA scores
HTML R Script Single Cell Analysis
PDF   Reference Manual
Text   NEWS


biocViews Classification, Clustering, MultipleComparison, Normalization, Preprocessing, SingleCell, Software
Version 1.0.0
In Bioconductor since BioC 3.18 (R-4.3) (< 6 months)
License GPL-3
Depends R (>= 4.3.0)
Imports ComplexHeatmap, dplyr, fgsea, ggplot2 (>= 3.0.0), graphics, grid, methods, MultiAssayExperiment, SummarizedExperiment, pracma, rlang, RSpectra, scales, stats
Suggests BiocStyle, circlize, ggpubr, KernSmooth, knitr, piggyback, reshape2, rmarkdown, rpart, Seurat (>= 4.0.0), spatstat.explore, stringr, survival, tidyverse, testthat (>= 3.0.0)
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package nipalsMCIA_1.0.0.tar.gz
Windows Binary
macOS Binary (x86_64) nipalsMCIA_1.0.0.tgz
macOS Binary (arm64) nipalsMCIA_1.0.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
Bioc Package Browser
Package Short Url
Package Downloads Report Download Stats
Old Source Packages for BioC 3.18 Source Archive

Documentation »


R / CRAN packages and documentation

Support »

Please read the posting guide. Post questions about Bioconductor to one of the following locations: