DOI: 10.18129/B9.bioc.isobar    

Analysis and quantitation of isobarically tagged MSMS proteomics data

Bioconductor version: Release (3.6)

isobar provides methods for preprocessing, normalization, and report generation for the analysis of quantitative mass spectrometry proteomics data labeled with isobaric tags, such as iTRAQ and TMT. Features modules for integrating and validating PTM-centric datasets (isobar-PTM). More information on

Author: Florian P Breitwieser < at> and Jacques Colinge <jacques.colinge at>, with contributions from Alexey Stukalov <stukalov at>, Xavier Robin <xavier.robin at> and Florent Gluck <florent.gluck at>

Maintainer: Florian P Breitwieser < at>

Citation (from within R, enter citation("isobar")):


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PDF R Script isobar for developers
PDF R Script isobar for quantification of PTM datasets
PDF R Script isobar package for iTRAQ and TMT protein quantification
PDF R Script Usecases for isobar package
PDF   Reference Manual
Text   NEWS


biocViews Bioinformatics, MassSpectrometry, MultipleComparisons, Proteomics, QualityControl, Software
Version 1.24.0
In Bioconductor since BioC 2.9 (R-2.14) (6.5 years)
License LGPL-2
Depends R (>= 2.10.0), Biobase, stats, methods
Imports distr, plyr, biomaRt, ggplot2
Suggests MSnbase, OrgMassSpecR, XML, RJSONIO, Hmisc, gplots, RColorBrewer, gridExtra, limma, boot, DBI, MASS
Depends On Me
Imports Me
Suggests Me RforProteomics
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